Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators

Autor: Daniel A. S. Kitagawa, Rafael B. Rodrigues, Thiago N. Silva, Wellington V. dos Santos, Vinicius C. V. da Rocha, Joyce S. F. D. de Almeida, Leandro B. Bernardo, Taynara Carvalho-Silva, Cintia N. Ferreira, Angelo A. T. da Silva, Alessandro B. C. Simas, Eugenie Nepovimova, Kamil Kuča, Tanos C. C. França, Samir F. de A. Cavalcante

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1369-1376 (2021)

Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a bro

Externí odkaz: https://doaj.org/article/64caf545eedf4c7299e2546a21467177

Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators

Autor: Tanos C. C. França, Angelo A.T. da Silva, Leandro B. Bernardo, Eugenie Nepovimova, Vinicius C V da Rocha, Taynara Carvalho-Silva, Thiago H. Silva, Cintia N. Ferreira, Joyce S. F. D. de Almeida, Wellington V Dos Santos, Rafael B. Rodrigues, Samir F. de A. Cavalcante, Kamil Kuca, Daniel A. S. Kitagawa, Alessandro B. C. Simas

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1369-1376 (2021)

Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a bro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50d48cd3065be20ef284226717b5ba8
https://doi.org/10.1080/14756366.2021.1916009

Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate

Autor: Joyce S. F. D. de Almeida, Ana Beatriz de A. Correa, Alessandro B. C. Simas, Wellington V Dos Santos, Samir F. de A. Cavalcante, Thiago N. da Silva, Leandro B. Bernardo, Tanos C. C. França, Rafael B. Rodrigues, Kamil Kuca, Daniel A. S. Kitagawa

Publikováno v: Chemico-Biological Interactions. 309:108682

Casualties caused by nerve agents, potent acetylcholinesterase inhibitors, have attracted attention from media recently. Poisoning with these chemicals may be fatal if not correctly addressed. Therefore, research on novel antidotes is clearly warrant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d768331c82a5d43b8db467912c1a7d40
https://doi.org/10.1016/j.cbi.2019.05.048