Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Wellington Pham"'
Autor:
Justin R. Haynes, Clayton A. Whitmore, William J. Behof, Charlotte A. Landman, Henry H. Ong, Andrew P. Feld, Isabelle C. Suero, Celeste B. Greer, John C. Gore, Printha Wijesinghe, Joanne A. Matsubara, Brian E. Wadzinski, Benjamin W. Spiller, Wellington Pham
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The classical amyloid cascade hypothesis postulates that the aggregation of amyloid plaques and the accumulation of intracellular hyperphosphorylated Tau tangles, together, lead to profound neuronal death. However, emerging research has demo
Externí odkaz:
https://doaj.org/article/c762f9905491477abe67360110002bce
Autor:
Qinyuan Alis Xu, Pierre Boerkoel, Veronica Hirsch-Reinshagen, Ian R. Mackenzie, Ging-Yuek Robin Hsiung, Geoffrey Charm, Elliott F. To, Alice Q. Liu, Katerina Schwab, Kailun Jiang, Marinko Sarunic, Mirza Faisal Beg, Wellington Pham, Jing Cui, Eleanor To, Sieun Lee, Joanne A. Matsubara
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract Amyloid beta (Aβ) deposits in the retina of the Alzheimer’s disease (AD) eye may provide a useful diagnostic biomarker for AD. This study focused on the relationship of Aβ with macroglia and microglia, as these glial cells are hypothesiz
Externí odkaz:
https://doaj.org/article/ba3b05c1e6ed405c896afaf90c90c798
Autor:
Printha Wijesinghe, Clayton A. Whitmore, Matthew Campbell, Charles Li, Miranda Tsuyuki, Eleanor To, Justin Haynes, Wellington Pham, Joanne A. Matsubara
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionErgothioneine (Ergo) is a naturally occurring dietary antioxidant. Ergo uptake is dependent on the transporter, organic cation transporter novel-type 1 (OCTN1) distribution. OCTN1 is highly expressed in blood cells (myeloid lineage cells)
Externí odkaz:
https://doaj.org/article/0779f6bc2f6f4b919ed9fe12418178cc
Autor:
William J. Behof, Clayton A. Whitmore, Justin R. Haynes, Adam J. Rosenberg, Mohammed N. Tantawy, Todd E. Peterson, Fiona E. Harrison, Robert B. Beelman, Wellington Pham
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Ergothioneine (ERGO) is a rare amino acid mostly found in fungi, including mushrooms, with recognized antioxidant activity to protect tissues from damage by reactive oxygen species (ROS) components. Prior to this publication, the biodistribu
Externí odkaz:
https://doaj.org/article/9f1da49055e5462fa3b225a7997b562e
Autor:
Clayton A. Whitmore, Justin R. Haynes, William J. Behof, Adam J. Rosenberg, Mohammed N. Tantawy, Brian C. Hachey, Brian E. Wadzinski, Benjamin W. Spiller, Todd E. Peterson, Krista C. Paffenroth, Fiona E. Harrison, Robert B. Beelman, Printha Wijesinghe, Joanne A. Matsubara, Wellington Pham
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 742 (2022)
Background: Ergothioneine (ERGO) is a unique antioxidant and a rare amino acid available in fungi and various bacteria but not in higher plants or animals. Substantial research data indicate that ERGO is a physiological antioxidant cytoprotectant. Di
Externí odkaz:
https://doaj.org/article/882ef7134def4279bbf43586617325cc
Autor:
Clayton A. Whitmore, Mariam I. Boules, William J. Behof, Justin R. Haynes, Dmitry Koktysh, Adam J. Rosenberg, Mohammed N. Tantawy, Wellington Pham
Publikováno v:
Molecules, Vol 26, Iss 8, p 2182 (2021)
Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease. However, so far, all of the studies were performed in vitro using extr
Externí odkaz:
https://doaj.org/article/cfd2eccd08f44b15bb163737bf294d85
Autor:
Wellington Pham, Shawn Barton, Bo Li, Michael Siuta, Vaibhav A. Janve, Jessica Song, Clinton M. Holt, Takumi Tomono, Masami Ukawa, Hironori Kumagai, Etsuo Tobita, Kevin Wilson, Shinji Sakuma
Publikováno v:
Precision Nanomedicine, Vol 1, Iss 3 (2018)
The Thomsen-Friedenreich (TF) antigen is a tumor-associated antigen consistently expressed on the apical surface of epithelial-based cancer cells, including pancreatic cancer. In this work, we report the development of multimodal imaging probe, the t
Externí odkaz:
https://doaj.org/article/c56a8962414042c48370c70d6d02a06b
Autor:
Shawn M. Barton, Eleanor To, Baxter P. Rogers, Clayton Whitmore, Manjosh Uppal, Joanne A. Matsubara, Wellington Pham
Publikováno v:
Molecules, Vol 26, Iss 4, p 835 (2021)
We present an integrated delivery technology herein employing the aerosolized method to repurpose thioflavin S for imaging amyloid beta (Abeta) deposits in the retina as a surrogate of Abeta in the brain for early detection of Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/8219219e34d74fe9a9eac0c70f61f7f4
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 12, Pp 1130-1137 (2007)
We report herein a method to track the migration of dendritic cells (DCs) using optical imaging. With the assistance of the delivery module, fluorescein isothiocyanate (FITC) could internalize inside DCs within 15 minutes of incubation. The fluoresce
Externí odkaz:
https://doaj.org/article/549004f0e87846a3a61bf3a3e9c1153c
Autor:
Ryan K. Robison, Justin R. Haynes, Sandeep K. Ganji, Charles P. Nockowski, Zoltan Kovacs, Wellington Pham, Victoria L. Morgan, Seth A. Smith, Reid C. Thompson, Reed A. Omary, John C. Gore, Changho Choi
Publikováno v:
Magnetic Resonance in Medicine.