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Data for paper 'A simulation model of periarterial clearance of amyloid-beta from the brain'

Autor: Diem, AK, Tan, M, Bresslof, N, Hawkes, C, Morris, AWJ, Weller, RO, Carare, RO

The accumulation of soluble and insoluble amyloid-beta (A-beta) in the brain indicates failure of elimination of A-beta from the brain with age and Alzheimer's disease. There is a variety of mechanisms for elimination of A-beta from the brain. They i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bccaa46c55becaf59fda63902157d8c2

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Akademický článek

Neuropathological assessment of artemether-treated severe malaria

Autor: Hien, TT, Turner, GDH, Mai, NTH, Phu, NH, Bethell, D, Blakemore, WF, Cavanagh, JB, Dayan, A, Medana, I, Weller, RO, Day, NPJ, White, NJ ^*

Publikováno v: In The Lancet 26 July 2003 362(9380):295-296

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Brain damage after profoundly hypothermic circulatory arrest: Correlations between neurophysiologic and neuropathologic findings

Autor: Thomas Vl, Weller Ro, Hunt Rh, Sedgwick Me, Fessatidis It, Shore Df

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 106:32-41

Five groups of neonatal pigs were subjected to cardiopulmonary bypass with circulatory arrest periods that varied from 70 to 120 minutes for the investigation of brain changes in induced deep-core hypothermia (15° C) with circulatory arrest. The par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aaf899c76a8fe9785d356287a5cc1c88
https://doi.org/10.1016/s0022-5223(19)33738-9

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Neuropathological Features of Profoundly Hypothermic Circulatory Arrest: An Experimental Study in the Pig

Autor: Thomas Vl, Weller Ro, Shore Df, Fessatidis It, Hunt Rh

Publikováno v: Cardiovascular Surgery. 1:155-160

Twenty-four neonatal pigs were exposed to periods of circulatory arrest of between 70 and 120 min under profound hypothermia at 15°C. Brain tissue taken 6h after cardiopulmonary bypass was examined histologically and by electron microscopy for evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd96a416e2d8737a0e552c5f527d0b16
https://doi.org/10.1177/096721099300100215

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Assessment of neurological injury due to circulatory arrest during profound hypothermia *1An experimental study in vertebrates

Autor: M V Venetikou, Thomas Vl, S. R. Bloom, Weller Ro, I. T. Fessatidis, Shore Df, F. Goodland, Hunt Rh, D. Rowe

Publikováno v: European Journal of Cardio-Thoracic Surgery. 7:465-473

To investigate brain changes in induced deep core hypothermia (15 °C) with circulatory arrest, five groups of neonatal pigs were subjected to cardiopulmonary bypass (CPB), with circulatory arrest (CA) periods varying from 70- 120 min. The parameters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2054b66321f4845ca2c91a9634c3fc31
https://doi.org/10.1016/1010-7940(93)90275-g

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The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease

Autor: Yu-Min Kuo, Beach, Tg, Sue, Li, Scott, S., Layne, Kj, Kokjohn, Ta, Kalback, Wm, Luehrs, Dc, Vishnivetskaya, Ta, Abramowski, D., Sturchler-Pierrat, C., Staufenbiel, M., Weller, Ro, Roher, Ae

Publikováno v: ResearcherID

BACKGROUND: High levels of A beta in the cerebral cortex distinguish demented Alzheimer's disease (AD) from nondemented elderly individuals, suggesting that decreased amyloid-beta (A beta) peptide clearance from the brain is a key precipitating facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c347bdab8a97ad2cf7862c49758fb46d
https://europepmc.org/articles/PMC1950067/

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Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease

Autor: Yu-Min Kuo, Crawford, F., Mullan, M., Kokjohn, Ta, Emmerling, MR, Weller, Ro, Roher, Ae

Publikováno v: Scopus-Elsevier
ResearcherID

BACKGROUND: Amyloid-beta (A beta) accumulates in plaques and as cerebral amyloid angiopathy (CAA) in the brains of both Alzheimer's disease (AD) patients and transgenic A betaPPswe/tg2576 (tg2576) mice. Increasingly, evidence in humans and mice shows

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6becff2e4afddff3e87d8a9512e115df
https://europepmc.org/articles/PMC1949958/

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Perivascular spaces in the basal ganglia of the human brain: their relationship to lacunes

Autor: Hutchings M, Pollock H, Weller Ro, E. T. Zhang

There is evidence for lymphatic drainage of interstitial fluid from the brain along perivascular spaces in a number of mammalian species. Ultrastructural studies suggest that there are similar drainage pathways in the human cerebral cortex. Perivascu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7c71cfeac1154c7fab43b51dbbd145
https://europepmc.org/articles/PMC1467691/

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The role of neuropathology in neuroscience

Autor: Weller Ro

Publikováno v: Neuropathology and applied neurobiology. 23(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476f441a663d230aee5d859dc5b7580c
https://pubmed.ncbi.nlm.nih.gov/9061684

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