Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Weizhi, Ji"'
Autor:
Junjun Yao, Shaoxing Dai, Ran Zhu, Ju Tan, Qiancheng Zhao, Yu Yin, Jiansen Sun, Xuewei Du, Longjiao Ge, Jianhua Xu, Chunli Hou, Nan Li, Jun Li, Weizhi Ji, Chuhong Zhu, Runrui Zhang, Tianqing Li
Publikováno v:
eLife, Vol 12 (2024)
While accumulated publications support the existence of neurogenesis in the adult human hippocampus, the homeostasis and developmental potentials of neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucle
Externí odkaz:
https://doaj.org/article/93a3ab54d6c74bddb587cac9943768a2
Autor:
Jingkuan Wei, Shaoxing Dai, Yaping Yan, Shulin Li, Pengpeng Yang, Ran Zhu, Tianzhuang Huang, Xi Li, Yanchao Duan, Zhengbo Wang, Weizhi Ji, Wei Si
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Fetal stages are critical periods for brain development. However, the protein molecular signature and dynamics of the human brain remain unclear due to sampling difficulty and ethical limitations. Non-human primates present similar developme
Externí odkaz:
https://doaj.org/article/e942bb9e9ba7438997ee0959ab542337
Autor:
Hui Zhang, Jiaming Li, Yang Yu, Jie Ren, Qiang Liu, Zhaoshi Bao, Shuhui Sun, Xiaoqian Liu, Shuai Ma, Zunpeng Liu, Kaowen Yan, Zeming Wu, Yanling Fan, Xiaoyan Sun, Yixin Zhang, Qianzhao Ji, Fang Cheng, Peng-Hu Wei, Xibo Ma, Shiqiang Zhang, Zhengwei Xie, Yuyu Niu, Yan-Jiang Wang, Jing-Dong J. Han, Tao Jiang, Guoguang Zhao, Weizhi Ji, Juan Carlos Izpisua Belmonte, Si Wang, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113396- (2023)
Externí odkaz:
https://doaj.org/article/3e6630844d194e75b7324d8432efa3a6
Autor:
Lizhu Xu, Dan Wang, Lu Zhao, Zhengsheng Yang, Xu Liu, Xinyue Li, Tingli Yuan, Ye Wang, Tianzhuang Huang, Ning Bian, Yuqun He, Xinglong Chen, Baohong Tian, Zexian Liu, Fucheng Luo, Wei Si, Guangping Gao, Weizhi Ji, Yuyu Niu, Jingkuan Wei
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106197- (2023)
Poly(PR) is a dipeptide repeat protein comprising proline and arginine residues. It is one of the translational product of expanded G4C2 repeats in the C9orf72 gene, and its accumulation is contributing to the neuropathogenesis of C9orf72-associated
Externí odkaz:
https://doaj.org/article/928c68336bd441fdba5b8c5b31da1c1b
Autor:
Jun Li, Nan Li, Jingkuan Wei, Chun Feng, Yanying Chen, Tingwei Chen, Zongyong Ai, Xiaoqing Zhu, Weizhi Ji, Tianqing Li
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Although striatal delivery of three critical genes for dopamine synthesis by viruses is a potential clinical approach for treating Parkinson’s disease (PD), the approach makes it difficult to finely control dopamine secretion amounts and b
Externí odkaz:
https://doaj.org/article/907e9d158b8f42f9b2b400c46e2d79df
Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex
Autor:
Ying Lei, Mengnan Cheng, Zihao Li, Zhenkun Zhuang, Liang Wu, Yunong sun, Lei Han, Zhihao Huang, Yuzhou Wang, Zifei Wang, Liqin Xu, Yue Yuan, Shang Liu, Taotao Pan, Jiarui Xie, Chuanyu Liu, Giacomo Volpe, Carl Ward, Yiwei Lai, Jiangshan Xu, Mingyue Wang, Hao Yu, Haixi Sun, Qichao Yu, Chunqing Wang, Chi Wai Wong, Wei Liu, Liangzhi Xu, Jingkuan Wei, Dandan Chen, Zhouchun Shang, Guibo Li, Kun Ma, Le Cheng, Fei Ling, Tao Tan, Kai Chen, Bosiljka Tasic, Michael Dean, Weizhi Ji, Huanming Yang, Ying Gu, Miguel A. Esteban, Yuxiang Li, Ao Chen, Yuyu Niu, Hongkui Zeng, Yong Hou, Longqi Liu, Shiping Liu, Xun Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Cell type epigenetic and topographic information of primate brain is lacking. Here, authors identified transcriptional regulatory network, gradient expression pattern and disease vulnerability at cell type level in PFC, M1 and V1 of monkey brain by s
Externí odkaz:
https://doaj.org/article/0ab4d766decf4a70b2a80a3a8ff72b4b
Autor:
Haonan Li, Xiaodan Wang, Yalong Wang, Mengxian Zhang, Fan Hong, Hong Wang, Along Cui, Jianguo Zhao, Weizhi Ji, Ye-Guang Chen
Publikováno v:
Cell Regeneration, Vol 11, Iss 1, Pp 1-16 (2022)
Abstract Animal models are widely used for biomedical studies and drug evaluation. The small intestine plays key roles in nutrient absorption, hormone secretion, microbiota defense and drug absorption and metabolism. Although the intestinal structure
Externí odkaz:
https://doaj.org/article/6368c7a03722402cbb1a0c7ad645b72b
Autor:
Shuaiwei Ren, Mei Huang, Raoxian Bai, Lijiao Chen, Jiao Yang, Junyu Zhang, Wenting Guo, Weizhi Ji, Yongchang Chen
Publikováno v:
Research, Vol 6 (2023)
Splice-switching antisense oligonucleotides (ASOs) and engineered U7 small nuclear ribonucleoprotein (U7 Sm OPT) are the most commonly used methods for exon skipping. However, challenges remain, such as limited organ delivery and repeated dosing for
Externí odkaz:
https://doaj.org/article/3eb6bbb0d25c42debfbc3283139a7e1e
Autor:
Haonan Li, Yalong Wang, Mengxian Zhang, Hong Wang, Along Cui, Jianguo Zhao, Weizhi Ji, Ye-Guang Chen
Publikováno v:
Cell Regeneration, Vol 10, Iss 1, Pp 1-10 (2021)
Abstract Pig and monkey are widely used models for exploration of human diseases and evaluation of drug efficiency and toxicity, but high cost limits their uses. Organoids have been shown to be promising models for drug test as they reasonably preser
Externí odkaz:
https://doaj.org/article/65f2fd618a8b4c9f89e7a80800f25203
Autor:
Yaping Yan, Shuchao Ren, Yanchao Duan, Chenyu Lu, Yuyu Niu, Zhengbo Wang, Briauna Inglis, Weizhi Ji, Yun Zheng, Wei Si
Publikováno v:
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. However, it is unclear whether microbiota and metabolites have demonstrated changes at early PD due to the difficulties in diagnosis and identification of ear
Externí odkaz:
https://doaj.org/article/755df831524046c7887d57638305af25