Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Weizheng Wei"'
Cognitive impairment (CI), a debilitating and pervasive feature of multiple sclerosis (MS), is correlated with hippocampal atrophy. Findings from postmortem MS hippocampi indicate that expression of genes involved in both excitatory and inhibitory ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c31b6dbb6025b968a062f6909567e33
https://europepmc.org/articles/PMC6289277/
https://europepmc.org/articles/PMC6289277/
Autor:
Andrey Damianov, Celine K. Vuong, Luis de la Torre-Ubieta, Chia-Ho Lin, Ji-Ann Lee, Kelsey C. Martin, Douglas L. Black, Thomas J. O'Dell, Reem Halabi, Weizheng Wei, Klara Olofsdotter Otis
Publikováno v:
Neuron, vol 98, iss 1
Dysfunction of the neuronal RNA binding protein RBFOX1 has been linked to epilepsy and autism spectrum disorders. Rbfox1 loss in mice leads to neuronal hyper-excitability and seizures, but the physiological basis for this is unknown. We identify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703f573374dfd3e3f585a2467c7fb846
https://pubmed.ncbi.nlm.nih.gov/29621488
https://pubmed.ncbi.nlm.nih.gov/29621488
Autor:
Christine Huang, Nianhui Zhang, Yliana Cetina, Zechun Peng, Thomas S. Otis, Weizheng Wei, Carolyn R. Houser
Publikováno v:
The Journal of Neuroscience. 33:14392-14405
Axonal sprouting of excitatory neurons is frequently observed in temporal lobe epilepsy, but the extent to which inhibitory interneurons undergo similar axonal reorganization remains unclear. The goal of this study was to determine whether somatostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee8c66df1dc6a2d2a76444a5e1250ab
https://doi.org/10.1523/jneurosci.2045-13.2013
https://doi.org/10.1523/jneurosci.2045-13.2013
Autor:
Michael V. Sofroniew, Quan Lin, Jifang Tao, Yi E. Sun, Weizheng Wei, Richard W. Olsen, X. William Yang, Hao Wu, Jeffrey P. Cantle, Istvan Mody, Yan Ao, Xiao-Hong Lu
Publikováno v:
The Journal of Neuroscience. 31:8306-8319
The endoribonuclease, Dicer, is indispensable for generating the majority of mature microRNAs (miRNAs), which are posttranscriptional regulators of gene expression involved in a wide range of developmental and pathological processes in the mammalian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6dace05fc5771e4fc92438fa3dbe17
https://doi.org/10.1523/jneurosci.0567-11.2011
https://doi.org/10.1523/jneurosci.0567-11.2011
Autor:
Viktor Kharazia, Weizheng Wei, Chao Zhang, Dan Wang, Heidi M. B. Lesscher, Doo Sup Choi, Istvan Mody, Thomas A. McMahon, Werner Sieghart, J. Kevin Deitchman, Kevan M. Shokat, Zhan Heng Qi, Robert O. Messing
Publikováno v:
The Journal of Neuroscience. 28:11890-11899
Ethanol alters the distribution and abundance of PKCδ in neural cell lines. Here we investigated whether PKCδ also regulates behavioral responses to ethanol. PKCδ−/−mice showed reduced intoxication when administered ethanol and reduced ataxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a89f8bda94890163a4bd21323a9481
https://doi.org/10.1523/jneurosci.3156-08.2008
https://doi.org/10.1523/jneurosci.3156-08.2008
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(28)
Complex changes in GABAAreceptors (GABAARs) in animal models of temporal lobe epilepsy during the chronic period include a decrease in the δ subunit and increases in the α4 and γ2 subunits in the dentate gyrus. We used postembedding immunogold lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31f7aa68ea1d483ff784e050f238335
https://pubmed.ncbi.nlm.nih.gov/17626213
https://pubmed.ncbi.nlm.nih.gov/17626213
Publikováno v:
Alcohol (Fayetteville, N.Y.). 41(3)
Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system (CNS) it acts on two distinct types of receptor: an ion channel, i.e., an “ionotropic” receptor permeable to Cl- and HCO3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00068a3b68a7d316def1a083e9fab0e
https://pubmed.ncbi.nlm.nih.gov/17521846
https://pubmed.ncbi.nlm.nih.gov/17521846
Autor:
Shiaoching Gong, X. William Yang, Xiaofeng Gu, Shihua Li, Takuji Iwasato, Victor Lo, Istvan Mody, Xiao-Jiang Li, Shigeyoshi Itohara, Weizheng Wei, Chenjian Li, Nathaniel Heintz
Publikováno v:
Neuron. 46(3)
SummaryExpanded polyglutamine (polyQ) proteins in Huntington’s disease (HD) as well as other polyQ disorders are known to elicit a variety of intracellular toxicities, but it remains unclear whether polyQ proteins can elicit pathological cell-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ac01af9a94f4f71fd36b037e01b98a
https://pubmed.ncbi.nlm.nih.gov/15882643
https://pubmed.ncbi.nlm.nih.gov/15882643
In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by δ subunit-containing GABAAreceptors, this conductance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e460c7e17dd63575d5a1f15de4ce1b6
https://europepmc.org/articles/PMC6729680/
https://europepmc.org/articles/PMC6729680/
Autor:
Christopher J. Evans, Cui-Wei Xie, Brigitte L. Kieffer, Weizheng Wei, Wendy Walwyn, Duane E. Keith, A.M Tan, Nigel T. Maidment
Publikováno v:
Neuroscience. 123(1)
Although mu opioid receptors desensitize in various cell lines in vitro, the relationship of this change in signaling efficacy to the development of tolerance in vivo remains uncertain. It is clear that a system is needed in which functional mu opioi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ce20d4e50d830d7fa2ea392976be92
https://pubmed.ncbi.nlm.nih.gov/14667446
https://pubmed.ncbi.nlm.nih.gov/14667446