Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Weiyi, Lai"'
Autor:
Sandhya Malla, Kanchan Kumari, Carlos A. García-Prieto, Jonatan Caroli, Anna Nordin, Trinh T. T. Phan, Devi Prasad Bhattarai, Carlos Martinez-Gamero, Eshagh Dorafshan, Stephanie Stransky, Damiana Álvarez-Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Ludvig Lizana, Jonathan D. Gilthorpe, Hailin Wang, Simone Sidoli, Andre Mateus, Dung-Fang Lee, Claudio Cantù, Manel Esteller, Andrea Mattevi, Angel-Carlos Roman, Francesca Aguilo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem
Externí odkaz:
https://doaj.org/article/2d6f847ecfc84532b688deb0fc0250d8
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Post‐replicative DNA N6‐methyladenine (pr6mdA) can form via bona fide methylase‐catalyzed adenine methylation, playing a pivotal role in embryonic development and other biological processes. Surprisingly, pre‐methylated adenine can b
Externí odkaz:
https://doaj.org/article/59b532f368f943f083d3cb61bacd341f
Autor:
Xiang Ao, Tao Jiang, Yuan Li, Weiyi Lai, Zhengnan Lian, Liang Wang, Minjun Huang, Zhongmin Zhang
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108721- (2024)
Summary: n-3 polyunsaturated fatty acids (PUFAs) are closely related to the progression of numerous chronic inflammatory diseases, but the role of n-3 PUFAs in the intervertebral disc degeneration (IVDD) remains unclear. In this study, male C57BL/6 w
Externí odkaz:
https://doaj.org/article/a67f3e504bc549d9b13c0faf36ce6aa9
Autor:
Yahan Yang, Ruiyang Li, Yifan Xiang, Duoru Lin, Anqi Yan, Wenben Chen, Zhongwen Li, Weiyi Lai, Xiaohang Wu, Cheng Wan, Wei Bai, Xiucheng Huang, Qiang Li, Wenrui Deng, Xiyang Liu, Yucong Lin, Pisong Yan, Haotian Lin
Publikováno v:
Intelligent Medicine, Vol 3, Iss 2, Pp 144-149 (2023)
Medical artificial intelligence (AI) and big data technology have rapidly advanced in recent years, and they are now routinely used for image-based diagnosis. China has a massive amount of medical data. However, a uniform criteria for medical data qu
Externí odkaz:
https://doaj.org/article/3d328aa3ca674d368ac778e0215ab343
Autor:
Yuhua Deng, Xiaofei Ge, Yan Li, Bin Zou, Xiaofeng Wen, Weirong Chen, Lin Lu, Meifen Zhang, Xiaomin Zhang, Chunmei Li, Chan Zhao, Xiaofeng Lin, Xiulan Zhang, Xinhua Huang, Xiaorong Li, Ming Jin, Guang-Hua Peng, Dongni Wang, Xun Wang, Weiyi Lai, Juanran Liang, Jing Jing Li, Qiaoxing Liang, Liu Yang, Qinfen Zhang, Yinyin Li, Ping Lu, Xiao Hu, Xifang Li, Xiuli Deng, Yu Liu, Yanli Zou, Shixin Guo, Tingting Chen, Yali Qin, Fuhua Yang, Li Miao, Wei Chen, Chi-Chao Chan, Haotian Lin, Yizhi Liu, Richard W. J. Lee, Lai Wei
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/7bd23cb418ea40ea9d4217692e352631
Autor:
Cong Lyu, Yamei Niu, Weiyi Lai, Yu Wang, Yaning Wang, Peibin Dai, Chunhui Ma, Shaokun Chen, Yao Li, Guibin Jiang, Zhiyong Liang, Wenbin Ma, Zhengliang Gao, Wei-Min Tong, Hailin Wang
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract The entity of DNA N6-methyladenine (6mA) in mammals remains elusive and subsequently its roles in diseases are poorly understood. Here we exploited a bacterial DNA contamination-free and ultrasensitive UHPLC-MS/MS assay to reassess DNA 6mA i
Externí odkaz:
https://doaj.org/article/9dfac327a6ab418eabca4d82c3b2024f
Autor:
Xiuzhi Wang, Mengke Wang, Xinyuan Dai, Xiao Han, Yu Zhou, Weiyi Lai, Liyuan Zhang, Ying Yang, Yusheng Chen, Hailin Wang, Yong-Liang Zhao, Bin Shen, Yuhan Zhang, Ying Huang, Yun-Gui Yang
Publikováno v:
Fundamental Research, Vol 2, Iss 1, Pp 48-55 (2022)
5-Methylcytosine (m5C) is one of the most prevalent internal modifications of messenger RNA (mRNA) in higher eukaryotes. Here we report that Y box protein 2 (YBX2) serves as a novel mammalian m5C binding protein to undergo liquid-liquid phase separat
Externí odkaz:
https://doaj.org/article/5fed98427eee4d53905739dc41ed09ac
Autor:
Yuhua Deng, Xiaofei Ge, Yan Li, Bin Zou, Xiaofeng Wen, Weirong Chen, Lin Lu, Meifen Zhang, Xiaomin Zhang, Chunmei Li, Chan Zhao, Xiaofeng Lin, Xiulan Zhang, Xinhua Huang, Xiaorong Li, Ming Jin, Guang-Hua Peng, Dongni Wang, Xun Wang, Weiyi Lai, Juanran Liang, Jing Jing Li, Qiaoxing Liang, Liu Yang, Qinfen Zhang, Yinyin Li, Ping Lu, Xiao Hu, Xifang Li, Xiuli Deng, Yu Liu, Yanli Zou, Shixin Guo, Tingting Chen, Yali Qin, Fuhua Yang, Li Miao, Wei Chen, Chi-Chao Chan, Haotian Lin, Yizhi Liu, Richard W. J. Lee, Lai Wei
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract The current dogma in ophthalmology and vision research presumes the intraocular environment to be sterile. However, recent evidence of intestinal bacterial translocation into the bloodstream and many other internal organs including the eyes,
Externí odkaz:
https://doaj.org/article/147327c1b400468397ed4f94e9cdea8d
Publikováno v:
Analytical Chemistry. 94:17670-17676
Epigenetic DNA modifications, such as 5-methylcytosine, 5-hydroxymethylcytosine, and 5-formylcytosine, are associated with a variety of diseases and potential biomarkers for cancer diagnosis and therapy. Liquid chromatography-tandem mass spectrometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfc566aeb381fad9c478ced1c6e1ae4
https://doi.org/10.1021/acs.analchem.2c04485
https://doi.org/10.1021/acs.analchem.2c04485
Autor:
Wenteng He, Xiaobai Zhang, Yalin Zhang, Weisheng Zheng, Zeyu Xiong, Xinjie Hu, Mingzhu Wang, Linfeng Zhang, Kun Zhao, Zhibin Qiao, Weiyi Lai, Cong Lv, Xiaochen Kou, Yanhong Zhao, Jiqing Yin, Wenqiang Liu, Yonghua Jiang, Mo Chen, Ruimin Xu, Rongrong Le, Chong Li, Hong Wang, Xiaoping Wan, Hailin Wang, Zhiming Han, Cizhong Jiang, Shaorong Gao, Jiayu Chen
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 477-493 (2018)
Summary: Androgenetic haploid embryonic stem cells (AG-haESCs) hold great promise for exploring gene functions and generating gene-edited semi-cloned (SC) mice. However, the high incidence of self-diploidization and low efficiency of SC mouse product
Externí odkaz:
https://doaj.org/article/35ce65bc9b0047eba2496601d1500e7d