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Figure S3 from Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance

Autor: Yong Yang, Qingyi Zhu, Jin-Rong Zhou, Jinsong Bian, Weiyan Tao, Yan Cheng, Jingjing Duan, Xiaofang Gao, Wanli Ye, Shijia Du, Xianjing Li, Zhuo Wang, Zhen Chen, Guangjiang Shi, Zhili Zhao, Yan Li, Linjun You, Hongxi Wu

Disruption of IRF8 in PCa cells affects cell growth in vitro and tumorigenesis in vivo.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8ae95d749b67c0638945ef3d73ad24
https://doi.org/10.1158/0008-5472.22424616

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Figure S2 from Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance

IRF8 expression is regulated by the androgen-AR pathway.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6be068486fc62336eb377c08b59563
https://doi.org/10.1158/0008-5472.22424619.v1

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Figure S4 from Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance

Figure S4. IRF8 reduces AR protein levels and activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490d521a56ecf392de4a5493960a51d7
https://doi.org/10.1158/0008-5472.22424613

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Supplementary Table from Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance

IRF8 was not frequently mutated and methylated in clinical PCa tissues and cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d01c2e654ccce805b4d90bd8e752f0
https://doi.org/10.1158/0008-5472.22424598.v1

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Figure S7 from Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance

IFNα enhances ENZ sensitivity targeting the AR/IRF8 axis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7431e48c56ff4a5f6b3440e7a84c6cf3
https://doi.org/10.1158/0008-5472.22424601

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Data from Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance

In incurable castration-resistant prostate cancer (CRPC), resistance to the novel androgen receptor (AR) antagonist enzalutamide is driven mainly by AR overexpression. Here we report that the expression of interferon regulatory factor 8 (IRF8) is inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e886effb330b35da8ff4d89921debbc0
https://doi.org/10.1158/0008-5472.c.6511821.v1

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Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance

Autor: Xiaofang Gao, Jingjing Duan, Yong Yang, Jin-Song Bian, Guangjiang Shi, Zhen Chen, Zhili Zhao, Zhuo Wang, Yan Li, Shijia Du, Yan Cheng, Weiyan Tao, Qingyi Zhu, Linjun You, Xianjing Li, Jin-Rong Zhou, Hongxi Wu, Wanli Ye

Publikováno v: Cancer Res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14b407d43431420c9dc0ff46f597212
https://pubmed.ncbi.nlm.nih.gov/32341037

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Schisandrin B prevents ulcerative colitis and colitis-associated-cancer by activating focal adhesion kinase and influence on gut microbiota in an in vivo and in vitro model

Autor: Fei Quan, Dan-Dan Zhao, Qiuhua Cao, Zhisen Yang, Cheng Chen, Xin Chen, Zhen Chen, Weiyan Tao, Rui Sun, Sen Zhao, Duowei Wang, He Lihua, Jiani Li, Ran Qi, Kaiyong Hu, Yuan Lu, Yong Yang, Dong Ding, Xinghua Gao, Yan Luo

Publikováno v: European journal of pharmacology. 854

Colitis-associated cancer (CAC) has a close relationship with ulcerative colitis (UC). Therapeutic effect of Schisandrin B (SchB) on UC and CAC remains largely unknown. We investigated the preventative effect of SchB on the dextran sulphate sodium (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bec9a1cb6d798da17d4aac939628b3
https://pubmed.ncbi.nlm.nih.gov/30951716

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