Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Weixu Zhai"'
Autor:
Carl J Baldick, Michael J Wichroski, Annapurna Pendri, Ann W Walsh, Jie Fang, Charles E Mazzucco, Kevin A Pokornowski, Ronald E Rose, Betsy J Eggers, Mayla Hsu, Weixu Zhai, Guangzhi Zhai, Samuel W Gerritz, Michael A Poss, Nicholas A Meanwell, Mark I Cockett, Daniel J Tenney
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001086 (2010)
Small molecule inhibitors of hepatitis C virus (HCV) are being developed to complement or replace treatments with pegylated interferons and ribavirin, which have poor response rates and significant side effects. Resistance to these inhibitors emerges
Externí odkaz:
https://doaj.org/article/1ee8b0be7b894e5398d932dbcf2e4866
Autor:
Andrew C. Good, Joe Shi, Catherine R. Burton, Samuel Gerritz, John E. Macor, Weixu Zhai, Shirong Zhu, Richard E. Olson, Jeremy H. Toyn, James E. Grace, Donna M. Barten, Yunhui Zhang, Jere E. Meredith, Kimberley A. Lentz, Lorin A. Thompson, Yong-Jin Wu, Charles F. Albright, Jason M. Guernon, Kenneth M. Boy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5040-5047
The synthesis, evaluation, and structure-activity relationships of a class of acyl guanidines which inhibit the BACE-1 enzyme are presented. The prolinyl acyl guanidine chemotype (7c), unlike compounds of the parent isothiazole chemotype (1), yielded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b930dff1463e1d5670f3e942574f4e4b
https://doi.org/10.1016/j.bmcl.2015.10.031
https://doi.org/10.1016/j.bmcl.2015.10.031
Autor:
John E. Macor, Ramesh Padmanabha, Jere E. Meredith, Jeremy H. Toyn, William J. Metzler, Andrew J. Tebben, Jodi K. Muckelbauer, Charles F. Albright, Lynda S. Cook, Lorin A. Thompson, Samuel Gerritz, Michael J. Sofia, Michael A. Poss, Shirong Zhu, Lawrence G. Iben, Daniel M. Camac, Kimberley A. Lentz, Shuhao Shi, Andrew C. Good, Weixu Zhai, Catherine R. Burton
Publikováno v:
Journal of Medicinal Chemistry. 55:9208-9223
This report describes the discovery and optimization of a BACE-1 inhibitor series containing an unusual acyl guanidine chemotype that was originally synthesized as part of a 6041-membered solid-phase library. The synthesis of multiple follow-up solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf4562a5f10ca9a8478ab177aed261b
https://doi.org/10.1021/jm300931y
https://doi.org/10.1021/jm300931y
Publikováno v:
Tetrahedron Letters. 53:267-270
This manuscript describes a convenient method for the direct amidation of methyl and ethyl β-ketoesters to generate solid-supported β-ketohydroxamates or β-ketoamides and the application of this methodology to the synthesis of 1,5-disubstituted py
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b0029f985244f8d1f13d976988906de
https://doi.org/10.1016/j.tetlet.2011.11.031
https://doi.org/10.1016/j.tetlet.2011.11.031
Publikováno v:
Tetrahedron Letters. 48:7203-7206
There currently are a wide variety of methods for forming C–N bonds on solid support. Two preferred methods are reductive aminations with resin bound amines or aldehydes as well as standard alkylation strategies. We herein disclose the scope and ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b5f42070aeb73efffff9c29feeffb6d
https://doi.org/10.1016/j.tetlet.2007.07.192
https://doi.org/10.1016/j.tetlet.2007.07.192
Autor:
Zhiyong Tao, Ambikaipakan Balasubramaniam, Sulaiman Sheriff, Claude Roze, William T. Chance, David W. McFadden, Marc Laburthe, Carson D. Liu, John E. Taylor, Thierry Voisin, Josef E. Fischer, Weixu Zhai, Peter E. Eden, Meiczyslawa Stein
Publikováno v:
Journal of Medicinal Chemistry. 43:3420-3427
Peptide YY (PYY) is a gut hormone that inhibits secretion and promotes absorption and growth in the intestinal epithelium. We have performed structure-activity studies with the active site, N-alpha-Ac-PYY(22-36)-NH(2), for interaction with intestinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f16b6df23d6ce9f8e0ff5228a8b342d
https://doi.org/10.1021/jm000052z
https://doi.org/10.1021/jm000052z
Autor:
C. J. Andres, Weixu Zhai, Katharine A. Grant-Young, Gail K. Mattson, Lawrence G. Iben, Milind Deshpande, Ildiko Antal Zimanyi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2883-2885
The synthesis of novel ligands for the NPY 2 receptor using solid phase split pool methodology is described. One of the analogues, diamine 16 , was found to be a potent NPY 2 binder.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7a7366c03a43faabd59b575c6b70cc
https://doi.org/10.1016/s0960-894x(03)00554-7
https://doi.org/10.1016/s0960-894x(03)00554-7
Publikováno v:
Tetrahedron Letters. 35:9371-9374
The asymmetric synthesis of (-)-Statine is described. The key step of the synthesis involves the coupling of hemi-acetal 6 with the ketene silyl acetal of methyl acetate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae9989860e5a3f77463034b588a6bd95
https://doi.org/10.1016/s0040-4039(00)78545-5
https://doi.org/10.1016/s0040-4039(00)78545-5
Autor:
Kevin Kish, Joanne J. Bronson, Kingsley K. Appiah, Samuel Gerritz, Carolyn Diane Dzierba, Yanling Huang, Weixu Zhai, Valentina Goldfarb, Shuhao Shi, Patricia A. McDonnell, Shirong Zhu, Mian Gao, John E. Macor, Susan E. Kiefer, Brett R. Beno, Jonathan O’Connell, Walter Kostich, Steven Sheriff, Joseph Yanchunas, Ryan Westphal
Publikováno v:
Journal of medicinal chemistry. 54(19)
Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline-aspartate (WPD) loop in catalysis. In previously determined structures of PTPs, the WPD-loop has been obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccdd52c2615390c1ce92e0881687381
https://pubmed.ncbi.nlm.nih.gov/21882820
https://pubmed.ncbi.nlm.nih.gov/21882820
Publikováno v:
ChemInform. 24
The asymmetric [1,3]-dipolar cycloaddition reactions of azomethine ylides derived from (SR,6S)-2,3,5,6-tetrahydro-5,6-diphenyl-1,4-oxazin-2-one with various aldehydes and methyl maleate is described. The reactions prove to be highly endo-selective, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74d3b16ea9cebba06ecf275350e9313a
https://doi.org/10.1002/chin.199314052
https://doi.org/10.1002/chin.199314052