Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Weixing Zhao"'
Autor:
Yuxin Huang, Wenjing Li, Tzeh Foo, Jae-Hoon Ji, Bo Wu, Nozomi Tomimatsu, Qingming Fang, Boya Gao, Melissa Long, Jingfei Xu, Rouf Maqbool, Bipasha Mukherjee, Tengyang Ni, Salvador Alejo, Yuan He, Sandeep Burma, Li Lan, Bing Xia, Weixing Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB fold 1 (OB1) of the BRCA2 DSS1/DNA-binding domain (DBD) which is frequently targeted by cancer-associated pathogenic vari
Externí odkaz:
https://doaj.org/article/f3092df21106479a9c84ccc7612b0ff2
Autor:
Jessica L. Kelliher, Melissa L. Folkerts, Kaiyuan V. Shen, Wan Song, Kyle Tengler, Clara M. Stiefel, Seong-Ok Lee, Eloise Dray, Weixing Zhao, Brian Koss, Nicholas R. Pannunzio, Justin W. Leung
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The master DNA damage repair histone protein, H2AX, is essential for orchestrating the recruitment of downstream mediator and effector proteins at damaged chromatin. The phosphorylation of H2AX at S139, γH2AX, is well-studied for its DNA re
Externí odkaz:
https://doaj.org/article/f40958dd8a9b496c9a1c7b226404941a
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103294- (2024)
Summary: The tumor suppressor breast cancer 1 (BRCA1) complexed with BRCA1-associated RING domain 1 (BARD1), a RING-type E3 ligase, facilitates the attachment of ubiquitin onto the substrate protein. Here, we present a protocol for evaluating the E3
Externí odkaz:
https://doaj.org/article/6e718f931beb4697a100cdcab231bcc1
Autor:
Weixing Zhao MM, Jun Jiang MD, PhD
Publikováno v:
Cancer Control, Vol 31 (2024)
This study aimed to explore advances in biomarkers related to anti-angiogenic therapy in patients with non-small cell lung cancer (NSCLC), thereby enhancing treatment selection, advancing personalized and precision medicine to improve treatment outco
Externí odkaz:
https://doaj.org/article/46a3f2cc725946c6a308cd53b9933230
Autor:
Xinyue Huang, Yating Ming, Weixing Zhao, Rui Feng, Yuanyue Zhou, Lijie Wu, Jia Wang, Jinming Xiao, Lei Li, Xiaolong Shan, Jing Cao, Xiaodong Kang, Huafu Chen, Xujun Duan
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Objective There has been increasing evidence for atypical white matter (WM) microstructure in autistic people, but findings have been divergent. The development of autistic people in early childhood is clouded by the concurrently rapid brain
Externí odkaz:
https://doaj.org/article/a238751013a44edd8728c9db1fbc4026
Publikováno v:
Chengshi guidao jiaotong yanjiu, Vol 27, Iss 1, Pp 50-54,60 (2024)
[Objective] The complex environmental and geological conditions surrounding metro foundation pit construction can easily lead to accidents. It is necessary to analyze the reasons for significant deformation of foundation pit retaining piles and propo
Externí odkaz:
https://doaj.org/article/478911f3efdb4b0eb005d112d85dfa43
Publikováno v:
Foods, Vol 13, Iss 6, p 966 (2024)
Climate change poses a high risk to grain yields. Maize, rice, and wheat are the three major grain crops in China, Japan, and Korea. Assessing the impacts and risks of climate on the yields of these grain cops is crucial. An economy–climate model (
Externí odkaz:
https://doaj.org/article/0292a2d191644158b17f3356ca8b9a76
Autor:
Youngho Kwon, Heike Rösner, Weixing Zhao, Platon Selemenakis, Zhuoling He, Ajinkya S. Kawale, Jeffrey N. Katz, Cody M. Rogers, Francisco E. Neal, Aida Badamchi Shabestari, Valdemaras Petrosius, Akhilesh K. Singh, Marina Z. Joel, Lucy Lu, Stephen P. Holloway, Sandeep Burma, Bipasha Mukherjee, Robert Hromas, Alexander Mazin, Claudia Wiese, Claus S. Sørensen, Patrick Sung
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Exon 27 of the tumor suppressor BRCA2 encodes a portion of the protein crucial for DNA repair, genome maintenance, and tumor suppression. Here the authors show that this domain binds DNA and the RAD51 recombinase to enhance the assembly of RAD51-DNA
Externí odkaz:
https://doaj.org/article/31023ba9447a4531befe74ed9fc6d0e3
Autor:
Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun, Na-Oh Yunn, Yunjin Kim, Byung-Gyu Kim, Minwoo Wie, Eun A. Lee, Jae Sun Ra, Jung-Min Oh, Donghyun Lee, Keondo Lee, Jihan Kim, Seung Hyun Han, Kyong-Tai Kim, Wan Kyun Chung, Ki Hyun Nam, Jaehyun Park, ByungHoon Lee, Sunghoon Kim, Weixing Zhao, Sung Ho Ryu, Yun-Sil Lee, Kyungjae Myung, Yunje Cho
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.
Externí odkaz:
https://doaj.org/article/3a702a1ed24a45f995d55ea263c1b376
Publikováno v:
Nano-Micro Letters, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Formate can be synthesized electrochemically by CO2 reduction reaction (CO2RR) or formaldehyde oxidation reaction (FOR). The CO2RR approach suffers from kinetic-sluggish oxygen evolution reaction at the anode. To this end, an electrochemical
Externí odkaz:
https://doaj.org/article/20bdc3ee7740411a98b78de571dfa73f