Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Weixiang Guo"'
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112067- (2023)
Summary: The generation of neurons from quiescent radial-glia-like neural stem cells (RGLs) in adult brain goes hand in hand with the modulation of cellular metabolism. However, it is still unclear how the exact metabolic program governs the balance
Externí odkaz:
https://doaj.org/article/ac688cbb4a1c42afb9d4a67d62a8ab4f
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Exposure to a hypomagnetic field (HMF) influences the cognitive processes of various animals, from insects to human beings. The authors show that in mice exposed to HMF, adult hippocampal neurogenesis and hippocampusdependent learning are impaired an
Externí odkaz:
https://doaj.org/article/7628b1d0bf8f4ccb9e617f7ce80de814
Autor:
Changyong Tang, Weixiang Guo
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100374- (2021)
Summary: Adult neurogenesis, a process of generating newborn neurons from adult neural stem cells, is required for brain homeostasis, cognition, and affective behaviors. Deciphering the molecular mechanisms underlying adult neurogenesis will provide
Externí odkaz:
https://doaj.org/article/07ddc444a6a74068ae3428b596c658f3
Autor:
Junchen Chen, Xiaoxue Dong, Xuejun Cheng, Qiang Zhu, Jinyu Zhang, Qian Li, Xiaoli Huang, Min Wang, Liping Li, Weixiang Guo, Binggui Sun, Qiang Shu, Wen Yi, Xuekun Li
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108905- (2021)
Summary: Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an important function in diverse biological processes and diseases. However, the roles of Ogt in regulating neurogenesis remain largely unknown. Here, we show that
Externí odkaz:
https://doaj.org/article/696d204f2c3e45bb805cae6e4f6415ee
Autor:
Yuhan Wang, Ye Guo, Changyong Tang, Xiu Han, Mingyue Xu, Jing Sun, Yifei Zhao, Yiwen Zhang, Min Wang, Xiaofeng Cao, Xiaojuan Zhu, Weixiang Guo
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 3101-3117.e7 (2019)
Summary: Although adult neurogenesis recapitulates processes that occur during embryonic development, it exhibits distinct characteristics from the embryonic counterpart. However, the intrinsic mechanism underlying the differential regulation of neur
Externí odkaz:
https://doaj.org/article/bde98cdfa01143dd8017d10284c7095e
Autor:
Weixiang Guo, Eric D. Polich, Juan Su, Yu Gao, Devin M. Christopher, Andrea M. Allan, Min Wang, Feifei Wang, Guangfu Wang, Xinyu Zhao
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1651-1666 (2015)
Fragile X mental retardation protein (FMRP) and its autosomal paralog FXR2P are selective neuronal RNA-binding proteins, and mice that lack either protein exhibit cognitive deficits. Although double-mutant mice display more severe learning deficits t
Externí odkaz:
https://doaj.org/article/0bae537eb5f544b18264c75cad0185e0
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Externí odkaz:
https://doaj.org/article/d93706bda5fa47339c96a60008ad16b8
VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome.
Autor:
Weixiang Guo, Keita Tsujimura, Maky Otsuka I, Koichiro Irie, Katsuhide Igarashi, Kinichi Nakashima, Xinyu Zhao
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100215 (2014)
Rett syndrome (RTT) is a devastating neurodevelopmental disorder that occurs once in every 10,000-15,000 live female births. Despite intensive research, no effective cure is yet available. Valproic acid (VPA) has been used widely to treat mood disord
Externí odkaz:
https://doaj.org/article/f5c2536904d84b9a826d98f080248c89
Autor:
Changmei Liu, Zhao-Qian Teng, Andrea L McQuate, Emily M Jobe, Christa C Christ, Sergei J von Hoyningen-Huene, Marie D Reyes, Eric D Polich, Yina Xing, Yue Li, Weixiang Guo, Xinyu Zhao
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e51436 (2013)
Epigenetic mechanisms, including DNA methylation, histone modification, and microRNAs, play pivotal roles in stem cell biology. Methyl-CpG binding protein 1 (MBD1), an important epigenetic regulator of adult neurogenesis, controls the proliferation a
Externí odkaz:
https://doaj.org/article/cb7dc8c692254a38b00267a6032f5901
Autor:
Weixiang Guo, Erin L Crossey, Li Zhang, Stefano Zucca, Olivia L George, C Fernando Valenzuela, Xinyu Zhao
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19351 (2011)
Fetal alcohol exposure affects 1 in 100 children making it the leading cause of mental retardation in the US. It has long been known that alcohol affects cerebellum development and function. However, the underlying molecular mechanism is unclear.We d
Externí odkaz:
https://doaj.org/article/61d1e83976b543c59a56689f1907b180