Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Weixiang Bian"'
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112819- (2023)
Summary: The Notch signaling pathway controls cell growth, differentiation, and fate decisions. Dysregulation of Notch signaling has been linked to various human diseases. Notch receptor resides in multiple cellular compartments, and its translocatio
Externí odkaz:
https://doaj.org/article/02d3b4ef3c9042c6a8eb534b053bd9db
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101569- (2022)
Summary: Identification of protein interactors is fundamental to understanding their functions. Here, we describe a modified protocol for tandem affinity purification coupled with mass spectrometry (TAP/MS), which includes two-step purification. We d
Externí odkaz:
https://doaj.org/article/34561f7c834f44c6b38c0956b2bf444a
Autor:
Zhen Zhang, Yun-xin Lu, Fangzhou Liu, Lingjie Sang, Chengyu Shi, Shaofang Xie, Weixiang Bian, Jie-cheng Yang, Zuozhen Yang, Lei Qu, Shi-yi Chen, Jun Li, Lu Yang, Qingfeng Yan, Wenqi Wang, Peifen Fu, Jianzhong Shao, Xu Li, Aifu Lin
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Notch has been implicated in human cancers and is a putative therapeutic target. However, the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore, characterizing the detailed mechanisms governing Notch degradation
Autor:
Shuai Yang, Hua Jiang, Weixiang Bian, Wenyan Xu, Yifan Guo, Sha Song, Jiadong Zheng, Xiaoyu Kuang, Chenxi Wu, Xiang Ding, Xiaowei Guo, Lei Xue, Zijing Yu, Yongdeng Zhang, Hyung Don Ryoo, Xu Li, Xianjue Ma
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Unfolded protein response (UPR) is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. ER proteostasis is essential to adapt to cell proliferation and regeneration in development and tumorigenesis, but mechanisms link
Publikováno v:
Science advances, vol 8, iss 38
Dysregulation of the Notch–RBPJ (recombination signal-binding protein of immunoglobulin kappa J region) signaling pathway has been found associated with various human diseases including cancers; however, precisely how this key signaling pathway is
Publikováno v:
STAR protocols, vol 3, iss 3
Identification of protein interactors is fundamental to understanding their functions. Here, we describe a modified protocol for tandem affinity purification coupled with mass spectrometry (TAP/MS), which includes two-step purification. We detail the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1d14a3b7a5fcea21cccfa0e49ddf20
https://escholarship.org/uc/item/4dw914hp
https://escholarship.org/uc/item/4dw914hp
Autor:
Zongyang Qiu, Jing Huang, Kunpeng Liu, Xu Li, Weixiang Bian, Chong Zhang, Wei Xu, Shuai Wang, Qiang Zhou, Youhua Xie, Zewei Sun, Yingnan Hou, Shibo Jiang, Aifu Lin, Shaofang Xie, Peihan Wu, Chao Shan, Tingting Zheng, Lu Lu, Xiya Deng
Publikováno v:
Cell Research
The current coronavirus disease 2019 (COVID-19) pandemic presents a global public health challenge. The viral pathogen responsible, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), binds to the host receptor ACE2 through its spike (S) gl
Autor:
Yue Sui, Wenqi Wang, Wanyu Hao, Nan Li, Xianjue Ma, Litong Nie, Chao Wang, Weixiang Bian, Xu Li, Lianfeng Wu, Yingnan Hou, Wenyan Xu, Mengfan Tang, Junjie Chen, Huimin Zhang, Jun Qin, Jiadong Wang, Hua Jiang
Publikováno v:
Developmental Cell. 56:2902-2919.e8
The Notch signaling pathway controls cell growth, differentiation, and fate decisions, and its dysregulation has been linked to various human genetic disorders and cancers. To comprehensively understand the global organization of the Notch pathway an
Publikováno v:
Biochemical and Biophysical Research Communications. 485:95-101
LRSAM1, a RING-type E3 ubiquitin ligase, is essential for regulating cargo sorting, signaling pathways, cell adhesion and anti-bacterial autophagy. It is important to elucidate the mechanism that underlies the regulation of LRSAM1 E3 ligase activity.
Publikováno v:
Protein Expression and Purification. 129:158-161
LRSAM1 is a typical RING-finger E3 ubiquitin ligase that plays an important role in many processes. The expression and purification of LRSAM1 from Escherichiacoli had not yet been reported. Here, strategies to clone, express and purify recombinant LR