Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Weixia Zhong"'
Autor:
Yan Shi, Candy Lee, Peng Sang, Zaid Amso, David Huang, Weixia Zhong, Meng Gu, Lulu Wei, Vân T.B. Nguyen-Tran, Jingyao Zhang, Weijun Shen, Jianfeng Cai
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1648-1659 (2023)
Peptides are increasingly important resources for biological and therapeutic development, however, their intrinsic susceptibility to proteolytic degradation represents a big hurdle. As a natural agonist for GLP-1R, glucagon-like peptide 1 (GLP-1) is
Externí odkaz:
https://doaj.org/article/91dc5f2999f64c208779cc3f9f338555
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
The least shrew is among the subset of animals that are capable of vomiting and therefore serves as a valuable research model for investigating the biochemistry, molecular biology, pharmacology, and genomics of emesis. Both nausea and vomiting are as
Externí odkaz:
https://doaj.org/article/2dfe97afb52f4221937d6eeccde28dcc
The Contribution of Phospholipase C in Vomiting in the Least Shrew (Cryptotis Parva) Model of Emesis
Autor:
Weixia Zhong, Nissar A. Darmani
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Gq and Gβγ protein-dependent phospholipase C (PLC) activation is extensively involved in G protein-coupled receptor (GPCR)-mediated signaling pathways which are implicated in a wide range of physiological and pathological events. Stimulation of sev
Externí odkaz:
https://doaj.org/article/5cd0584a47d043bd8b97219a33c6b25f
Autor:
Weixia Zhong, Omar Shahbaz, Garrett Teskey, Abrianna Beever, Nala Kachour, Vishwanath Venketaraman, Nissar A. Darmani
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5797 (2021)
Nausea and vomiting are common gastrointestinal complaints that can be triggered by diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and vomiting are considered as defense mechanisms when threatening toxins/drugs/
Externí odkaz:
https://doaj.org/article/7159385e02a4496bb73871e6368de4e5
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104718 (2014)
Stimulation of 5-HT3 receptors (5-HT3Rs) by 2-methylserotonin (2-Me-5-HT), a selective 5-HT3 receptor agonist, can induce vomiting. However, downstream signaling pathways for the induced emesis remain unknown. The 5-HT3R channel has high permeability
Externí odkaz:
https://doaj.org/article/efb03d1766e441909126c2438de436ac
Autor:
Yifang Yang, Candy Lee, Reddy Rajasekhar Reddy, David J. Huang, Weixia Zhong, Vân T. B. Nguyen-Tran, Weijun Shen, Qing Lin
Publikováno v:
ACS Chem Biol
Recent clinical trials have revealed that the chimeric peptide hormones simultaneously activating glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) demonstrate superior efficacy in glycemic con
The Contribution of Phospholipase C in Vomiting in the Least Shrew (Cryptotis Parva) Model of Emesis
Autor:
Nissar A. Darmani, Weixia Zhong
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Gq and Gβγ protein-dependent phospholipase C (PLC) activation is extensively involved in G protein-coupled receptor (GPCR)-mediated signaling pathways which are implicated in a wide range of physiological and pathological events. Stimulation of sev
Autor:
Garrett Teskey, Weixia Zhong, Abrianna Beever, Omar Shahbaz, Nala Kachour, Nissar A. Darmani, Vishwanath Venketaraman
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5797, p 5797 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 5797, p 5797 (2021)
Nausea and vomiting are common gastrointestinal complaints that can be triggered by diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and vomiting are considered as defense mechanisms when threatening toxins/drugs/
Autor:
Nissar A. Darmani, Weixia Zhong
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Subtypes (1–4) of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are widely expressed in the central and peripheral nervous systems, as well as the cells of smooth muscles in many organs. They mainly serve to regulate cellul
Publikováno v:
Eur J Pharmacol
Akt (protein kinase B) signaling is frequently activated in diverse cancers. Akt inhibitors such as perifosine and MK-2206 have been evaluated as potential cancer chemotherapeutics. Although both drugs are generally well tolerated, among their most c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f10dc03bc5bdb99a76e49da02cff83b
https://europepmc.org/articles/PMC8085164/
https://europepmc.org/articles/PMC8085164/