FAP-Targeted Fluorescent Imaging Agents to Study Cancer-Associated Fibroblasts In Vivo.

Autor: Deutsch-Williams RJ; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States., Schleyer KA; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States., Das R; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States., Carrothers JE; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States., Kohler RH; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States., Vinegoni C; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States., Weissleder R; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2024 Dec 12. Date of Electronic Publication: 2024 Dec 12.

Targeted SPP1 Inhibition of Tumor-Associated Myeloid Cells Effectively Decreases Tumor Sizes.

Autor: Kartal B; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA., Garris CS; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA., Kim HS; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA., Kohler RH; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA., Carrothers J; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA., Halabi EA; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA., Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA., Goubet AG; Department of Pathology and Immunology, University of Geneva, Geneva, 1211, Switzerland.; AGORA Cancer Research Center, Swiss Cancer Center Leman, Lausanne, 1011, Switzerland., Xie Y; Department of Pathology and Immunology, University of Geneva, Geneva, 1211, Switzerland.; AGORA Cancer Research Center, Swiss Cancer Center Leman, Lausanne, 1011, Switzerland., Wirapati P; Department of Pathology and Immunology, University of Geneva, Geneva, 1211, Switzerland.; AGORA Cancer Research Center, Swiss Cancer Center Leman, Lausanne, 1011, Switzerland., Pittet MJ; Department of Pathology and Immunology, University of Geneva, Geneva, 1211, Switzerland.; AGORA Cancer Research Center, Swiss Cancer Center Leman, Lausanne, 1011, Switzerland.; Ludwig Institute for Cancer Research, Lausanne, 1005, Switzerland., Weissleder R; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA, 02114, USA.; Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, MA, 02115, USA.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Dec 05, pp. e2410360. Date of Electronic Publication: 2024 Dec 05.

Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment.

Autor: Shiau C; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cao J; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Gong D; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT Health Sciences and Technology Program, Cambridge, MA, USA., Gregory MT; NanoString Technologies, Seattle, WA, USA., Caldwell NJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Yin X; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cho JW; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Wang PL; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Su J; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Wang S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Reeves JW; NanoString Technologies, Seattle, WA, USA., Kim TK; NanoString Technologies, Seattle, WA, USA., Kim Y; NanoString Technologies, Seattle, WA, USA., Guo JA; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, USA., Lester NA; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Bae JW; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhao R; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schurman N; NanoString Technologies, Seattle, WA, USA., Barth JL; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ganci ML; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Weissleder R; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Jacks T; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Qadan M; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hong TS; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Wo JY; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Roberts H; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Beechem JM; NanoString Technologies, Seattle, WA, USA., Castillo CF; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Mino-Kenudson M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ting DT; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hemberg M; Broad Institute of MIT and Harvard, Cambridge, MA, USA. mhemberg@bwh.harvard.edu.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mhemberg@bwh.harvard.edu., Hwang WL; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. whwang1@mgh.harvard.edu.; Department of Radiation Oncology, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. whwang1@mgh.harvard.edu.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. whwang1@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. whwang1@mgh.harvard.edu.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. whwang1@mgh.harvard.edu.

Publikováno v: Nature genetics [Nat Genet] 2024 Nov; Vol. 56 (11), pp. 2466-2478. Date of Electronic Publication: 2024 Sep 03.

γ-Butyrolactone Derivatives of MSA-2 are STING Prodrugs.

Autor: Schleyer K; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA-02114., Halabi EA; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA-02114., Weissleder R; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA-02114.; Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, MA-02115.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Oct 01; Vol. 19 (19), pp. e202400416. Date of Electronic Publication: 2024 Aug 05.

Scission-Enhanced Molecular Imaging (SEMI).

Autor: Quintana JM; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Carlson JCT; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Scott E; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States., Ng TSC; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Miller MA; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Weissleder R; Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.; Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.; Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2024 Sep 10. Date of Electronic Publication: 2024 Sep 10.