Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Weiss-Puxbaum A"'
Autor:
Nina Kerres, Steffen Steurer, Stefanie Schlager, Gerd Bader, Helmut Berger, Maureen Caligiuri, Christian Dank, John R. Engen, Peter Ettmayer, Bernhard Fischerauer, Gerlinde Flotzinger, Daniel Gerlach, Thomas Gerstberger, Teresa Gmaschitz, Peter Greb, Bingsong Han, Elizabeth Heyes, Roxana E. Iacob, Dirk Kessler, Heike Kölle, Lyne Lamarre, David R. Lancia, Simon Lucas, Moriz Mayer, Katharina Mayr, Nikolai Mischerikow, Katja Mück, Christoph Peinsipp, Oliver Petermann, Ulrich Reiser, Dorothea Rudolph, Klaus Rumpel, Carina Salomon, Dirk Scharn, Renate Schnitzer, Andreas Schrenk, Norbert Schweifer, Diane Thompson, Elisabeth Traxler, Roland Varecka, Tilman Voss, Alexander Weiss-Puxbaum, Sandra Winkler, Xiaozhang Zheng, Andreas Zoephel, Norbert Kraut, Darryl McConnell, Mark Pearson, Manfred Koegl
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2860-2875 (2017)
The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We
Externí odkaz:
https://doaj.org/article/43ac770ae3294c078849cf3143253f8a
Autor:
Xiao-Ling Cockcroft, Stephan Karl Zahn, Mark Petronczki, Catherine M. Rogers, Fengling Li, Helmut Berger, Bernadette Sharps, Markus Zeeb, Ralph A. Neumüller, Mark Pearson, Dalia Barsyte-Lovejoy, Teresa Krammer, Oleg Fedorov, Barbara Müllauer, Alexander Weiss-Puxbaum, Kilian Huber, Masoud Vedadi, Magdalena M. Szewczyk, Christopher R. Vakoc, Abdellah Allali-Hassani, Tobias Wunberg, Steven Kennedy, Christoph Reiser, Michael Schleicher, Julian E. Fuchs, Cheryl H. Arrowsmith, Moriz Mayer, Jark Böttcher, Guido Boehmelt, Dietrich Böse, Alexandra Hörmann, Andreas Zoephel, Heribert Arnhof, Sandra Winkler, Darryl B. McConnell, Peter Brown, David Dilworth, Maja Corcokovic, Klaus Rumpel, Thomas Gerstberger, Nikolai Mischerikow, Carrow I. Wells, Ulrich Reiser, Daniela Häring
Publikováno v:
Nature Chemical Biology. 15:822-829
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is encoded by the WHSC1L1 gene located in the 8p11-p12 amplicon, frequently amplified in brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27dc86073fff4580d870ac18a39c74e3
https://doi.org/10.1038/s41589-019-0310-x
https://doi.org/10.1038/s41589-019-0310-x
Autor:
Gerhard Fischer, Jark Böttcher, Dirk Kessler, Alexander Weiss-Puxbaum, Melanie Hinkel, Sandra Döbel, Barbara Müllauer, Darryl B. McConnell, Andreas Bergner
Publikováno v:
Future medicinal chemistry. 12(21)
Activating mutations in the three human RAS genes, KRAS, NRAS and HRAS, are among the most common oncogenic drivers in human cancers. Covalent KRASG12C inhibitors, which bind to the switch II pocket in the ‘off state’ of KRAS, represent the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19be4c6d41af1a0f2597d0d35fd1f64a
https://pubmed.ncbi.nlm.nih.gov/32779487
https://pubmed.ncbi.nlm.nih.gov/32779487
Akademický článek
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Autor:
Simon Wöhrle, Tom Owen-Hughes, Jale Karolyi-Oezguer, Teresa Gmaschitz, Steffen Steurer, Bernadette Sharps, Heribert Arnhof, Gerd Bader, Joerg Rinnenthal, Thomas Gerstberger, Peter Greb, Manfred Koegl, Johannes Wachter, Michael Galant, Klaus Rumpel, Carina Riedmueller, William Farnaby, David Zollman, Peter Ettmayer, Meng-Ying Wu, Michael J. Roy, Emelyne Diers, Andreas Zoephel, Nicole Trainor, Darryl B. McConnell, Nicola Wiechens, Mark Pearson, Guido Boehmelt, Oliver Petermann, Alessio Ciulli, Renate Schnitzer, Harald Weinstabl, Christian Dank, Katharina Ehrenhöfer-Wölfer, Alexander Weiss-Puxbaum, Claire Whitworth, Elisabeth Traxler
Publikováno v:
Nature chemical biology
Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits SMARCA2 and SMARCA4 using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7294dabd3aa7131694badb1e13fb5c
https://pubmed.ncbi.nlm.nih.gov/31267096
https://pubmed.ncbi.nlm.nih.gov/31267096
Akademický článek
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Akademický článek
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Autor:
David R. Lancia, John R. Engen, Elizabeth Heyes, Katharina Mayr, Lyne Lamarre, Mark Pearson, Carina Salomon, Simon Lucas, Steffen Steurer, Alexander Weiss-Puxbaum, Klaus Rumpel, Gerlinde Flotzinger, Norbert Kraut, Xiaozhang Zheng, Daniel Gerlach, Katja Mück, Sandra Winkler, Heike Kölle, Peter Ettmayer, Nikolai Mischerikow, Christian Dank, Ulrich Reiser, Dirk Scharn, Bingsong Han, Teresa Gmaschitz, Andreas Schrenk, Nina Kerres, Norbert Schweifer, Dirk Kessler, Tilman Voss, Renate Schnitzer, Manfred Koegl, Roland Varecka, Moriz Mayer, Dorothea Rudolph, Oliver Petermann, Diane Thompson, Thomas Gerstberger, Christoph Peinsipp, Roxana E. Iacob, Stefanie Schlager, Gerd Bader, Helmut Berger, Peter Greb, Maureen Caligiuri, Elisabeth Traxler, Bernhard Fischerauer, Andreas Zoephel, Darryl B. McConnell
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2860-2875 (2017)
Summary The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fde7bf1e49edbe7d290947dd0fdf49
https://pubmed.ncbi.nlm.nih.gov/28930682
https://pubmed.ncbi.nlm.nih.gov/28930682
Autor:
Jale Karolyi-Oezguer, Renate Schnitzer, Heribert Arnhof, Emelyne Diers, Andreas Zoephel, Harald Weinstabl, Bernadette Sharps, Darryl B. McConnell, Katharina Ehrenhöfer-Wölfer, Peter Ettmayer, David Zollman, Joerg Rinnenthal, Guido Boehmelt, Michael J. Roy, Meng-Ying Wu, Alessio Ciulli, Thomas Gerstberger, Klaus Rumpel, William Farnaby, Carina Riedmueller, Alexander Weiss-Puxbaum, Nicole Trainor, Peter Greb, Mark Pearson, Johannes Wachter, Michael Galant, Steffen Steurer, Tom Owen-Hughes, Oliver Petermann, Simon Wöhrle, Manfred Koegl, Nicola Wiechens, Elisabeth Traxler, Gerd Bader, Teresa Gmaschitz, Christian Dank, Claire Whitworth
Publikováno v:
Nature Chemical Biology. 15:846-846
In the version of this article originally published, several lines of text in the last paragraph of the right column on page 1 of the PDF were transposed into the bottom paragraph of the left column. The affected text of the left column should read "
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7486b9d8ad9fe9437d9ccce229082c6
https://doi.org/10.1038/s41589-019-0329-z
https://doi.org/10.1038/s41589-019-0329-z
Akademický článek
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