Understanding the Increased Aggregation Propensity of a Light-Exposed IgG1 Monoclonal Antibody Using Hydrogen Exchange Mass Spectrometry, Biophysical Characterization, and Structural Analysis.

Autor: Bommana R; Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047., Chai Q; Eli Lilly Biotechnology Center, San Diego, California 92121., Schöneich C; Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047., Weiss WF 4th; Biopharmaceutical Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Majumdar R; Biopharmaceutical Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285. Electronic address: majumdar_ranajoy@lilly.com.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2018 Jun; Vol. 107 (6), pp. 1498-1511. Date of Electronic Publication: 2018 Jan 31.

Technical Decision Making With Higher Order Structure Data: Perspectives on Higher Order Structure Characterization From the Biopharmaceutical Industry.

Autor: Weiss WF 4th; Biopharmaceutical Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285. Electronic address: weisswf@lilly.com., Gabrielson JP; Elion Labs, 1450 Infinite Drive, Louisville, Colorado 80027., Al-Azzam W; BioPharm Analytical Sciences, Biopharmaceutical Development R&D, GlaxoSmithKline, King of Prussia, Pennsylvania 19406., Chen G; Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543., Davis DL; Janssen Research & Development LLC, Spring House, Pennsylvania 19477., Das TK; Biologics Development, Bristol-Myers Squibb Company, Pennington, New Jersey 08534., Hayes DB; Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877., Houde D; Protein Pharmaceutical Development, Biogen, Cambridge, Massachusetts 02142., Singh SK; Biotherapeutics Pharmaceutical Sciences, Pfizer, Inc., Chesterfield, Missouri 63017.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2016 Dec; Vol. 105 (12), pp. 3465-3470. Date of Electronic Publication: 2016 Oct 13.

Variability in Flow-Imaging Microscopy Measurements and Considerations for Biopharmaceutical Development.

Autor: Rauk AP; Global Statistical Sciences, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Griffiths KL; Global Statistical Sciences, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Gossage MD; Biopharmaceutical Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Weiss WF 4th; Biopharmaceutical Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285. Electronic address: weiss_william_f_iv@lilly.com.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2016 Nov; Vol. 105 (11), pp. 3296-3303. Date of Electronic Publication: 2016 Sep 20.

Technical decision-making with higher order structure data: starting a new dialogue.

Autor: Gabrielson JP; Attribute Sciences, Amgen Inc., Longmont, Colorado, 80503., Weiss WF 4th

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2015 Apr; Vol. 104 (4), pp. 1240-5. Date of Electronic Publication: 2015 Feb 24.

Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation.

Autor: Weiss WF 4th; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States., Zhang A; Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, United States., Ivanova MI; Molecular Biology Institute, University of California, Los Angeles, CA 90095, United States., Sahin E; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States., Jordan JL; Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, United States., Fernandez EJ; Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, United States., Roberts CJ; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States. Electronic address: cjr@udel.edu.

Publikováno v: Biophysical chemistry [Biophys Chem] 2014 Jan; Vol. 185, pp. 79-87. Date of Electronic Publication: 2013 Nov 28.