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Akademický článek

Autor: Qu Z (AUTHOR), Weiss JN (AUTHOR), Grant AO (EDITOR)

Publikováno v: Journal of Cardiovascular Electrophysiology. Sep2006, Vol. 17 Issue 9, p1042-1049. 8p.

Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue

Autor: Liu, MB, de Lange, E, Garfinkel, A, Weiss, JN, Qu, Z

Publikováno v: Liu, MB; Liu, MB; de Lange, E; de Lange, E; Garfinkel, A; Garfinkel, A; et al.(2015). Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue. Heart Rhythm. doi: 10.1016/j.hrthm.2015.06.019. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5xs2v77n

© 2015 Heart Rhythm Society. Background: Delayed afterdepolarizations (DADs) have been well characterized as arrhythmia triggers, but their role in generating a tissue substrate vulnerable to reentry is not well understood. Objective: The purpose of

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Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations

Autor: Madhvani, RV, Angelini, M, Xie, Y, Pantazis, A, Suriany, S, Borgstrom, NP, Garfinkel, A, Qu, Z, Weiss, JN, Olcese, R

Publikováno v: Madhvani, RV; Angelini, M; Xie, Y; Pantazis, A; Suriany, S; Borgstrom, NP; et al.(2015). Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations. Journal of General Physiology, 145(5), 395-404. doi: 10.1085/jgp.201411288. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5kv3631v

© 2015 Madhvani et al. Early afterdepolarizations (EADs) associated with prolongation of the cardiac action potential (AP) can create heterogeneity of repolarization and premature extrasystoles, triggering focal and reentrant arrhythmias. Because th

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Apamin does not inhibit human cardiac Na+current, L-type Ca2+current or other major K+currents

Autor: Yu, CC, Ai, T, Weiss, JN, Chen, PS

Publikováno v: Yu, CC; Ai, T; Weiss, JN; & Chen, PS. (2014). Apamin does not inhibit human cardiac Na+current, L-type Ca2+current or other major K+currents. PLoS ONE, 9(5). doi: 10.1371/journal.pone.0096691. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5531637h

Background: Apamin is commonly used as a small-conductance Ca2+-activated K+(SK) current inhibitor. However, the specificity of apamin in cardiac tissues remains unclear. Objective: To test the hypothesis that apamin does not inhibit any major cardia

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The emergence of subcellular pacemaker sites for calcium waves and oscillations

Autor: Nivala, M, Ko, CY, Weiss, JN, Qu, Z

Publikováno v: The Journal of physiology, vol 591, iss 21
Nivala, M; Ko, CY; Nivala, M; Weiss, JN; & Qu, Z. (2013). The emergence of subcellular pacemaker sites for calcium waves and oscillations. Journal of Physiology, 591(21), 5305-5320. doi: 10.1113/jphysiol.2013.259960. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6hp1074k

Calcium (Ca2+) waves generating oscillatory Ca2+ signals are widely observed in biological cells. Experimental studies have shown that under certain conditions, initiation of Ca2+ waves is random in space and time, while under other conditions, waves

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Regulation of cloned ATP-sensitive K channels by adenine nucleotides and sulfonylureas: interactions between SUR1 and positively charged domains on Kir6.2

Autor: John, SA, Weiss, JN, Ribalet, B

Publikováno v: The Journal of general physiology, vol 118, iss 4

K(ATP) channels, comprised of the pore-forming protein Kir6.x and the sulfonylurea receptor SURx, are regulated in an interdependent manner by adenine nucleotides, PIP2, and sulfonylureas. To gain insight into these interactions, we investigated the

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