VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

Autor: Chunsik Lee, Rongyuan Chen, Guangli Sun, Xialin Liu, Xianchai Lin, Chang He, Liying Xing, Lixian Liu, Lasse D. Jensen, Anil Kumar, Harald F. Langer, Xiangrong Ren, Jianing Zhang, Lijuan Huang, Xiangke Yin, JongKyong Kim, Juanhua Zhu, Guanqun Huang, Jiani Li, Weiwei Lu, Wei Chen, Juanxi Liu, Jiaxin Hu, Qihang Sun, Weisi Lu, Lekun Fang, Shasha Wang, Haiqing Kuang, Yihan Zhang, Geng Tian, Jia Mi, Bi-Ang Kang, Masashi Narazaki, Aaron Prodeus, Luc Schoonjans, David M. Ornitz, Jean Gariepy, Guy Eelen, Mieke Dewerchin, Yunlong Yang, Jing-Song Ou, Antonio Mora, Jin Yao, Chen Zhao, Yizhi Liu, Peter Carmeliet, Yihai Cao, Xuri Li

Publikováno v: Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)

Abstract Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs that inhibit VEGF-B together with o

Externí odkaz: https://doaj.org/article/ad0f2de2f96d45acbb44f158c21c99b6

The long non-coding RNA Snhg3 is essential for mouse embryonic stem cell self-renewal and pluripotency

Autor: Weisi Lu, Jianping Yu, Fengtao Shi, Jianing Zhang, Rui Huang, Shanshan Yin, Zhou Songyang, Junjiu Huang

Publikováno v: Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-12 (2019)

Abstract Background Small nucleolar RNA host gene 3 (Snhg3) is a long non-coding RNA (lncRNA) that was shown to participate in the tumorigenesis of certain cancers. However, little is known about its role in embryonic stem cells (ESCs). Methods Here,

Externí odkaz: https://doaj.org/article/dbdc4f04f9494d0ea86ab956e782de68

Expression and function of PDGF-C in development and stem cells

Autor: Xuri Li, Weisi Lu, Qin Jiang, Yi Tian, Ying Zhan

Publikováno v: Open Biology, Vol 11, Iss 12 (2021)
Open Biology

Platelet-derived growth factor C (PDGF-C) is a relatively new member of the PDGF family, discovered nearly 20 years after the finding of platelet-derived growth factor A (PDGF-A) and platelet-derived growth factor B (PDGF-B). PDGF-C is generally expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7904f57ba5895561783e3ee84586a8bd
https://royalsocietypublishing.org/doi/10.1098/rsob.210268

Interaction Between Sympk and Oct4 Promotes Mouse Embryonic Stem Cell Proliferation

Autor: Rui Huang, Junjiu Huang, Miaoman Ye, Zhou Songyang, Yaofu Bai, Jianping Yu, Tianyu Ge, Wenbin Ma, Guang Shi, Weisi Lu, Bohong Chen

Publikováno v: Stem Cells. 37:743-753

The scaffold protein Symplekin (Sympk) is involved in cytoplasmic RNA polyadenylation, transcriptional modulation, and the regulation of epithelial differentiation and proliferation via tight junctions. It is highly expressed in embryonic stem cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23f04ebd29eb9992cb72147eb124f38
https://doi.org/10.1002/stem.2992

Single-cell RNA sequencing reveals renal endothelium heterogeneity and metabolic adaptation to water deprivation

Autor: Peter Carmeliet, Laure-Anne Teuwen, Lin Lin, Luc Schoonjans, Guy Eelen, Rongyuan Chen, Carla De Legher, Tobias K. Karakach, Sébastien J. Dumas, Weisi Lu, Joanna Kalucka, Elda Meta, Lars Bolund, Nadine V. Conchinha, Mieke Dewerchin, Stefan Vinckier, Kim D. Falkenberg, Katerina Rohlenova, Federico Taverna, Yonglun Luo, Xuri Li, Jermaine Goveia, Laura P.M.H. de Rooij, Shawez Khan, Ton J. Rabelink, Magdalena Parys, Mila Borri

Publikováno v: J Am Soc Nephrol
Journal of the American Society of Nephrology
Dumas, S J, Meta, E, Borri, M, Goveia, J, Rohlenova, K, Conchinha, N V, Falkenberg, K, Teuwen, L-A, de Rooij, L, Kalucka, J, Chen, R, Khan, S, Taverna, F, Lu, W, Parys, M, De Legher, C, Vinckier, S, Karakach, T K, Schoonjans, L, Lin, L, Bolund, L, Dewerchin, M, Eelen, G, Rabelink, T J, Li, X, Luo, Y & Carmeliet, P 2020, ' Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation ', Journal of the American Society of Nephrology : JASN, vol. 31, no. 1, pp. 118-138 . https://doi.org/10.1681/ASN.2019080832
Journal of the American Society of Nephrology, 31(1), 118-138. AMER SOC NEPHROLOGY

BACKGROUND: Renal endothelial cells from glomerular, cortical, and medullary kidney compartments are exposed to different microenvironmental conditions and support specific kidney processes. However, the heterogeneous phenotypes of these cells remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0e38fe50f3082bab431c22dbafebb4
https://doi.org/10.1681/asn.2019080832