Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Weishi Yu"'
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021)
Abstract Background Variants identified through parent–child trio-WES yield up to 28–55% positive diagnostic rate across a variety of Mendelian disorders, there remain numerous patients who do not receive a genetic diagnosis. Studies showed that
Externí odkaz:
https://doaj.org/article/9e4d0d0e9f5a4c6b8bd5f611682928d5
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders. Mutations of the chromatin remodeling protein Lsh/HEL
Externí odkaz:
https://doaj.org/article/a8f0cb628e81496a856554a455852ef3
Autor:
Yongguang Tao, Herbert Yu, Kathrin Muegge, Weishi Yu, Ya Cao, Hu Zhou, Shuang Liu, Yan Cheng, Desheng Xiao, Rui Yang, Weiwei Lai, Xiaoli Liu, Yi Shen, Ying Shi, Yiqun Jiang, Bin Yan, Min Wang, Yating Liu, Xiang Wang, Chao Mao
Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that the cytosolic lncRNA P53RRA is downregulated in cancers and functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe4c5c9217df2e9b9db5eb440605bb2a
https://doi.org/10.1158/0008-5472.c.6510666.v1
https://doi.org/10.1158/0008-5472.c.6510666.v1
Autor:
Yongguang Tao, Herbert Yu, Kathrin Muegge, Weishi Yu, Ya Cao, Hu Zhou, Shuang Liu, Yan Cheng, Desheng Xiao, Rui Yang, Weiwei Lai, Xiaoli Liu, Yi Shen, Ying Shi, Yiqun Jiang, Bin Yan, Min Wang, Yating Liu, Xiang Wang, Chao Mao
Supplementary Material and Methods; Supplementary Tables 1-6; and Supplementary Figure S1-15. Figure S1 shows the P53RRA RNA levels were downregulated in cancer tissues and cells; Figure S2 shows LSH increased DNA methylation in the promoter of P53RR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520e03fb13826d62eb5bddbdda7170a3
https://doi.org/10.1158/0008-5472.22420476.v1
https://doi.org/10.1158/0008-5472.22420476.v1
Autor:
Chen Xi, Shuming Yin, Zhang Mei, Hongquan Geng, Yongguo Yu, Liren Wang, Shichang Li, Lie Ma, Yaqiang Hu, Mingyao Liu, Wenjuan Qiu, Yuting Guan, Weishi Yu, Honghui Han, Nan Shen, Dali Li, Shao Tingting
Publikováno v:
Science China Life Sciences. 65:718-730
Genome editing through adeno-associated viral (AAV) vectors is a promising gene therapy strategy for various diseases, especially genetic disorders. However, homologous recombination (HR) efficiency is extremely low in adult animal models. We assumed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f0438ff898e19b1b827023524c5842
https://doi.org/10.1007/s11427-020-1744-6
https://doi.org/10.1007/s11427-020-1744-6
Autor:
Shuming Yin, Yaqiang Hu, Meizhen Liu, Xueyun Ma, Honghui Han, Haibo Li, Dali Li, Liren Wang, Yanan Huo, Jun Wang, Mingyao Liu, Lei Yang, Hongquan Geng, Rui Zheng, Zhang Xiaohui, Chen Xi, Weishi Yu
Publikováno v:
Mol Ther
Base editing technology efficiently generates nucleotide conversions without inducing excessive double-strand breaks (DSBs), which makes it a promising approach for genetic disease therapy. In this study, we generated a novel hereditary tyrosinemia t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3659cd1fc72694ae1540b819c3081906
https://doi.org/10.1016/j.ymthe.2020.05.001
https://doi.org/10.1016/j.ymthe.2020.05.001
Autor:
Honghui Han, Bailian Cai, Yuxuan Wu, Mengjia Hong, Zhiyong Mao, Yifan Huang, Lei Yang, Caiyu Chen, Zhang Xiaohui, Dali Li, Zuozhen Yang, Liang Chen, Meizhen Liu, Ying Zhang, Biyun Zhu, Weishi Yu, Huiying Li, Liren Wang, Mingyao Liu, Shuming Yin
Publikováno v:
Nature Cell Biology. 22:740-750
Cytidine base editors are powerful genetic tools that catalyse cytidine to thymidine conversion at specific genomic loci, and further improvement of the editing range and efficiency is critical for their broader applications. Through insertion of a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b861c6ba95f690838e1cbd5eff0ac984
https://doi.org/10.1038/s41556-020-0518-8
https://doi.org/10.1038/s41556-020-0518-8
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021)
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021)
Background Variants identified through parent–child trio-WES yield up to 28–55% positive diagnostic rate across a variety of Mendelian disorders, there remain numerous patients who do not receive a genetic diagnosis. Studies showed that some aber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faebd669a5bde2794eace3cb46ce449d
https://doi.org/10.1186/s12920-021-01008-8
https://doi.org/10.1186/s12920-021-01008-8
Autor:
Jian-Zhong Shao, Qiwei Ge, Jian Liu, Luo-jia Yang, Hui Chen, Huai-Qiang Ju, Weishi Yu, Wenqi Wang, Ling-jie Sang, Hang-di Gong, Zuo-zhen Yang, Chengyu Shi, Hai-long Piao, Zhen Zhang, Fang-zhou Liu, Liangjing Wang, Minjie Wu, Qingfeng Yan, Qianqian Zhuang, Rui-hua Li, Lei Qu, Aifu Lin, Hao Chen, Tianhua Zhou
Organelles entail specialized molecules to regulate their essential cellular processes. However, systematically elucidating the subcellular distribution of functional molecules such as long non-coding RNAs (lncRNAs) in tissue homeostasis and diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec12f5e3adf487b451b8951a36da03e5
https://doi.org/10.21203/rs.3.rs-78018/v1
https://doi.org/10.21203/rs.3.rs-78018/v1
Autor:
Yiqun Jiang, Weishi Yu, Kathrin Muegge, Yongguang Tao, Xiang Wang, Weiwei Lai, Herbert Yu, Yating Liu, Bin Yan, Yi Shen, Hu Zhou, Xiaoli Liu, Ying Shi, Desheng Xiao, Shuang Liu, Yan Cheng, Ya Cao, Min Wang, Chao Mao, Rui Yang
Publikováno v:
Cancer Res
Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that the cytosolic lncRNA P53RRA is downregulated in cancers and functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e5d01e3e2db2b69696c659090e1337
https://doi.org/10.1158/0008-5472.can-17-3454
https://doi.org/10.1158/0008-5472.can-17-3454