Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Weisheng V. Chen"'
Autor:
Nagendran Ramalingam, Shan-Xue Jin, Tim E. Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P. Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V. Mosharov, Weisheng V. Chen, Shaomin Li, Dennis J. Selkoe, Ulf Dettmer
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological role for pS129 has remained undefined. Here we use mult
Externí odkaz:
https://doaj.org/article/d183b6fc70b54d8f9e89896f83034181
Autor:
Cameron Arakaki, Xiao-Bing Zhang, Lu Zhang, Leslie Aranda, Ya-Wen Fu, Tao Cheng, Wei Wen, Guo-Hua Li, Wanqiu Chen, Xiao-Lan Li, Hannah Choi, Juan Fu, Chang-Kai Sun, Prue Talbot, David J. Baylink, Gary D. Botimer, Rachel Bechar, Weisheng V Chen, Mei Zhao, Jian-Ping Zhang
Publikováno v:
Nucleic Acids Research
Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for functional genomics, disease modeling, and regenerative medicine. However, low editing efficiency has hampered the applications of CRISPR–Cas9 technology in creating
Autor:
Maxime Chevee, Franck Polleux, Sean O'Keeffe, George Mountoufaris, Tom Maniatis, Yusuke Hirabayashi, Weisheng V. Chen, Chiamaka L. Nwakeze
Publikováno v:
Science. 356:411-414
Pattern formation in the brain Neurons in the developing brain cooperate to build circuits. Mountoufaris et al. found that ∼50 variable protocadherin genes support a combinatorial identity code that allows millions of olfactory neuron axons to sort
The ability of neurites of individual neurons to distinguish between themselves and neurites from other neurons and to avoid self (self-avoidance) plays a key role in neural circuit assembly in both invertebrates and vertebrates. Similarly, when indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8219777c492d04f1c996bc2abc51591
https://resolver.caltech.edu/CaltechAUTHORS:20181023-111350854
https://resolver.caltech.edu/CaltechAUTHORS:20181023-111350854
Autor:
Sean O'Keeffe, Joseph D. Dougherty, Qiang Wu, Tom Maniatis, Christine A. Denny, Amy Kirner, Michael A. Rieger, René Hen, Chiamaka L. Nwakeze, Weisheng V. Chen, George Mountoufaris
Pattern formation in the brain Neurons in the developing brain cooperate to build circuits. Mountoufaris et al. found that ∼50 variable protocadherin genes support a combinatorial identity code that allows millions of olfactory neuron axons to sort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f69b596356d27e3cf3f1c141dba1f6
https://europepmc.org/articles/PMC5529183/
https://europepmc.org/articles/PMC5529183/
Autor:
Chan Aye Thu, Rotem Rubinstein, Lawrence Shapiro, Barry Honig, Weisheng V. Chen, Klara Felsovalyi, Juan Carlos Tapia, Holly N. Wolcott, Maxime Chevee, Tom Maniatis
Publikováno v:
Cell. 158(5):1045-1059
SummaryIndividual mammalian neurons stochastically express distinct repertoires of α, β, and γ protocadherin (Pcdh) proteins, which function in neural circuit assembly. We report that all three subfamilies of clustered Pcdhs can engage in specific
Autor:
Tzu-Ting Chiou, Rashid Ali, Angel L. De Blas, Haiyan Xiao, Tom Maniatis, Bevan Bonhomme, Hongbing Jin, Yanfang Li, Noelia Pinal, Weisheng V. Chen, Celia P. Miralles
Publikováno v:
The Journal of Neuroscience. 32:11780-11797
We have found that the γ2 subunit of the GABAAreceptor (γ2-GABAAR) specifically interacts with protocadherin-γC5 (Pcdh-γC5) in the rat brain. The interaction occurs between the large intracellular loop of the γ2-GABAAR and the cytoplasmic domain
Autor:
Joshua R. Sanes, Eric J. Geiman, Bosiljka Tasic, Juan Carlos Tapia, Chan Aye Thu, Brad A. Friedman, Tom Maniatis, Courtney A. Smith, Chiamaka L. Nwakeze, Weisheng V. Chen, Julie L. Lefebvre, Francisco J. Alvarez
Publikováno v:
Neuron. 75(3):402-409
SummaryThe mammalian Protocadherin (Pcdh) alpha, beta, and gamma gene clusters encode a large family of cadherin-like transmembrane proteins that are differentially expressed in individual neurons. The 22 isoforms of the Pcdhg gene cluster are divers
Publikováno v:
Nature
Dendritic arborizations of many neurons are patterned by a process called self-avoidance, in which branches arising from a single neuron repel each other. By minimizing gaps and overlaps within the arborization, self-avoidance facilitates complete co
Autor:
Nadine Beetz, Lindsey J. Macpherson, Sean O'Keeffe, Juan Carlos Tapia, Tom Maniatis, Eric N. Olson, Junqiang Ye, Rhonda Bassel-Duby, Weisheng V. Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(23)
We report that mice lacking the heterogeneous nuclear ribonucleoprotein U (hnRNP U) in the heart develop lethal dilated cardiomyopathy and display numerous defects in cardiac pre-mRNA splicing. Mutant hearts have disorganized cardiomyocytes, impaired