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Decreased p53 is associated with a decline in asymmetric stem cell self‐renewal in aged human epidermis.

Autor: Charruyer, Alexandra^1,2 (AUTHOR), Weisenberger, Tracy^1,2 (AUTHOR), Li, Hang^1,2 (AUTHOR), Khalifa, Ayman^1,2,3 (AUTHOR), Schroeder, Andrew W.⁴ (AUTHOR), Belzer, Annika^1,2,5 (AUTHOR), Ghadially, Ruby^1,2 (AUTHOR) ruby.ghadially@ucsf.edu

Publikováno v: Aging Cell. Feb2021, Vol. 20 Issue 2, p1-16. 16p.

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants.

Autor: Desautels TA; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Arrildt KT; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Zemla AT; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Lau EY; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Zhu F; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Ricci D; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Cronin S; Vanderbilt Vaccine Center, Nashville, TN 37232, USA., Zost SJ; Vanderbilt Vaccine Center, Nashville, TN 37232, USA., Binshtein E; Vanderbilt Vaccine Center, Nashville, TN 37232, USA., Scheaffer SM; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Dadonaite B; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Petersen BK; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Engdahl TB; Vanderbilt Vaccine Center, Nashville, TN 37232, USA., Chen E; Vanderbilt Vaccine Center, Nashville, TN 37232, USA., Handal LS; Vanderbilt Vaccine Center, Nashville, TN 37232, USA., Hall L; Vanderbilt Vaccine Center, Nashville, TN 37232, USA., Goforth JW; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Vashchenko D; Applications Simulations and Quality Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Nguyen S; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Weilhammer DR; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Lo JK; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Rubinfeld B; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Saada EA; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Weisenberger T; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Lee TH; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Whitener B; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Ladd A; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Silva MS; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Haluska RM; Applications Simulations and Quality Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Grzesiak EA; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Earnhart CG; Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense, US, Department of Defense, Frederick, MD 21703, USA., Hopkins S; Joint Research & Development, Inc., Stafford, VA 22556, USA., Bates TW; Global Security Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Thackray LB; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Segelke BW; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Lillo AM; Los Alamos National Laboratory, Bioscience Division, Los Alamos, NM 87545, USA., Sundaram S; Center for Bioengineering, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Bloom J; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Seattle, WA 98195, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Crowe JE Jr; Vanderbilt Vaccine Center, Nashville, TN 37232, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Carnahan RH; Vanderbilt Vaccine Center, Nashville, TN 37232, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Faissol DM; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 24. Date of Electronic Publication: 2023 Apr 24.