Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Weirong Qin"'
Autor:
Qianling Zhang, Hongdong Shi, Jin-Gang Liu, Zigang Li, Yi Wang, Xiaoyan Chai, Pingyu Zhang, Haijie Chen, Weirong Qin
Publikováno v:
Dalton Transactions. 49:972-976
An HCBP1 peptide-ruthenium conjugate (Ru-β-Ala-FQHPSFI) as a potential candidate for targeted therapy of hepatoma was synthesized. Ru-β-Ala-FQHPSFI shows drastically enhanced cytotoxicity and high selectivity for hepatoma cells versus noncancer liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42f84e923a34d71513fa91b641daa88
https://doi.org/10.1039/c9dt03856f
https://doi.org/10.1039/c9dt03856f
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2827-2836
Estrogen receptor α (ERα) is a crucial target for ERα positive breast cancer treatment. Previous drug discovery efforts were focused on developing inhibitors that targeted the canonical ligand binding pockets of the ligand binding domain (LBD) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ba7887fcacdb88cf71b252eff95f5a
https://doi.org/10.1016/j.bmcl.2018.05.062
https://doi.org/10.1016/j.bmcl.2018.05.062
Autor:
Lizhong Liu, Yujie Wu, Zigang Li, Rongtong Zhao, Xiaodong Shi, Bili Zhu, Feng Yin, Peigen Ren, Mingsheng Xie, Weirong Qin, Dan Yang, Bin Teng, Hui Zhao
Publikováno v:
Journal of Medicinal Chemistry. 61:8174-8185
Insulin-degrading enzyme (IDE) plays a critical role in both the proteolytic degradation and inactivation of insulin. The exploration of novel IDE inhibitors could aid in the study of novel therapeutics for type-2 diabetes. Herein, we report a hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86570cd0f58f6fa7205a5eb98f56df8
https://doi.org/10.1021/acs.jmedchem.8b00418
https://doi.org/10.1021/acs.jmedchem.8b00418
Publikováno v:
Organic & Biomolecular Chemistry. 16:5764-5770
Antimicrobial peptides (AMPs) are short cationic peptides with a high affinity for membranes and emerged as a promising therapeutic approach with potential for treating infectious diseases. Chemical stabilization of short peptides proved to be a succ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a4f5e7c075b0630303a1b1b9574f1a
https://doi.org/10.1039/c8ob00483h
https://doi.org/10.1039/c8ob00483h
Autor:
Weirong Qin, Jingxu Li, Hui Zhao, Xiaodong Shi, Yanhong Jiang, Rongtong Zhao, Zigang Li, Yuan Tian, Yixiang Jiang, Feng Yin
Publikováno v:
Chemical Science. 9:3227-3232
We have developed a general peptide macrocyclization strategy that involves a facile and chemoselective methionine bis-alkylation/dealkylation process. This method provides a straightforward and easy approach to generate cyclic peptides with toleranc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3f8e7ebbc9974a3451e04b2b2400d23
https://doi.org/10.1039/c7sc05109c
https://doi.org/10.1039/c7sc05109c
Autor:
Kuan Hu, Rui Ma, Qianling Zhang, Feng Yin, Huasen Wang, Xuan Qin, Hui Zhao, Weirong Qin, Yongye Liang, Chengjie Sun, Dan Yang, Zigang Li
Publikováno v:
Chemical Science
An easily accessible fluorescent dye, FEB, which has a high fluorescence quantum yield and is suitable for in vivo tumour imaging is reported.
A fluorescent dye, FEB, with high fluorescence quantum yield for tumour imaging is reported. FEB dyes
A fluorescent dye, FEB, with high fluorescence quantum yield for tumour imaging is reported. FEB dyes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d3e0a64ac3aba90a44fa0a73264d04
https://doi.org/10.1039/c7sc02698f
https://doi.org/10.1039/c7sc02698f