Cognitive health among older adults in the United States and in England

Autor: Wallace Robert B, Weir David R, Lang Iain A, Llewellyn David J, Langa Kenneth M, Kabeto Mohammed U, Huppert Felicia A

Publikováno v: BMC Geriatrics, Vol 9, Iss 1, p 23 (2009)

Abstract Background Cognitive function is a key determinant of independence and quality of life among older adults. Compared to adults in England, US adults have a greater prevalence of cardiovascular risk factors and disease that may lead to poorer

Externí odkaz: https://doaj.org/article/7a139d46b0654900b840dfc8a57ec40f

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Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Autor: Surendran, Praveen, Young, Robin, Barnes, Daniel R., Nielsen, Sune Fallgaard, Rasheed, Asif, Samuel, Maria, Zhao, Wei, Kontto, Jukka, Perola, Markus, Caslake, Muriel, de Craen, Anton J.M., Trompet, Stella, Uria-Nickelsen, Maria, Malarstig, Anders, Reily, Dermot F., Hoek, Maarten, Vogt, Thomas, Jukema, J. Wouter, Sattar, Naveed, Ford, Ian, Packard, Chris J., Alam, Dewan S., Majumder, Abdulla al Shafi, Di Angelantonio, Emanuele, Chowdhury, Rajiv, Amouyel, Philippe, Arveiler, Dominique, Blankenberg, Stefan, Ferrières, Jean, Kee, Frank, Kuulasmaa, Kari, Müller-Nurasyid, Martina, Veronesi, Giovanni, Virtamo, Jarmo, EPIC-CVD Consortium, Frossard, Philippe, Nordestgaard, Børge Grønne, Saleheen, Danish, Danesh, John, Butterworth, Adam S., Howson, Joanna M.M., Erzurumluoglu, A. Mesut, Jackson, Victoria E., Melbourne, Carl A., Varga, Tibor V., Warren, Helen R., Tragante, Vinicius, Tachmazidou, Ioanna, Harris, Sarah E., Evangelou, Evangelos, Marten, Jonathan, Zhang, Weihua, Altmaier, Elisabeth, Luan, Jian’an, Langenberg, Claudia, Scott, Robert A., Yaghootkar, Hanieh, Stirrups, Kathleen, Kanoni, Stavroula, Marouli, Eirini, Karpe, Fredrik, Dominiczak, Anna F., Sever, Peter, Poulter, Neil, Rolandsson, Olov, Baumbach, Clemens, Afaq, Saima, Chambers, John C., Kooner, Jaspal S., Wareham, Nicholas J., Renström, Frida, Hallmans, Göran, Marioni, Riccardo E., Corley, Janie, Starr, John M., Verweij, Niek, de Boer, Rudolf A., van der Meer, Peter, Yavas, Ersin, Vaartjes, Ilonca, Bots, Michiel L., Asselbergs, Folkert W., Grabe, Hans J., Völzke, Henry, Nauck, Matthias, Weiss, Stefan, Pharoah, Paul D.P., Dunning, Alison M., Dennis, Joe G., Thompson, Deborah J., Michailidou, Kyriaki, Easton, Douglas F., Antoniou, Antonis C., Tyrrell, Jessica, Mihailov, Evelin, Samani, Nilesh J., Zhou, Kaixin, Neville, Matthew J., Metspalu, Andres, Palmer, Colin N.A., Hall, Ian P., Strachan, David P., Deary, Ian J., Frayling, Tim M., Hayward, Caroline, van der Harst, Pim, Zeggini, Eleftheria, Understanding Society Scientific Group, Munroe, Patricia B., Jansson, Jan-Håkan, Franks, Paul W., Deloukas, Panos, Caulfield, Mark J., Wain, Louise V., Tobin, Martin D., Brazel, David M., Jiang, Yu, Hughey, Jordan M., Turcot, Valérie, Zhan, Xiaowei, Gong, Jian, Batini, Chiara, Weissenkampen, J. Dylan, Liu, MengZhen, Bertelsen, Sarah, Chou, Yi-Ling, Faul, Jessica D., Haessler, Jeff, Hammerschlag, Anke R., Hsu, Chris, Kapoor, Manav, Lai, Dongbing, Le, Nhung, de Leeuw, Christiaan A., Loukola, Anu, Mangino, Massimo, Pistis, Giorgio, Qaiser, Beenish, Rohde, Rebecca, Shao, Yaming, Stringham, Heather, Wetherill, Leah, Agrawal, Arpana, Bierut, Laura, Chen, Chu, Eaton, Charles B., Goate, Alison, Haiman, Christopher, Heath, Andrew, Iacono, William G., Martin, Nicholas G., Polderman, Tinca J., Reiner, Alex, Rice, John, Schlessinger, David, Scholte, H. Steven, Smith, Jennifer A., Tardif, Jean-Claude, Tindle, Hilary A., van der Leij, Andries R., Boehnke, Michael, Chang-Claude, Jenny, Cucca, Francesco, David, Sean P., Foroud, Tatiana, Kardia, Sharon L.R., Kooperberg, Charles, Laakso, Markku, Lettre, Guillaume, Madden, Pamela, McGue, Matt, North, Kari, Posthuma, Danielle, Spector, Timothy, Stram, Daniel, Weir, David R., Kaprio, Jaakko, Abecasis, Gonçalo R., Liu, Dajiang J., Vrieze, Scott

Publikováno v: In Biological Psychiatry 1 June 2019 85(11):946-955

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Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Autor: Mathieson, Iain, Day, Felix R., Barban, Nicola, Tropf, Felix C., Brazel, David M., van Heemst, Diana, Vaez, Ahmad, van Zuydam, Natalie, Bitarello, Bárbara D., Gardner, Eugene J., Akimova, Evelina T., Azad, Ajuna, Bergmann, Sven, Bielak, Lawrence F., Boomsma, Dorret I., Bosak, Kristina, Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey Smith, George, Davies, Gail, Deary, Ian J., Esko, Tõnu, Faul, Jessica D., Franco, Oscar, Ganna, Andrea, Gaskins, Audrey J., Gelemanovic, Andrea, de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Gopinath, Bamini, Grabe, Hans Jörgen, Gunderson, Erica P., Hayward, Caroline, He, Chunyan, Hill, W. David, Hoffmann, Eva R., Homuth, Georg, Hottenga, Jouke Jan, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M. Arfan, Jansen, Rick, Johannesson, Magnus, Kamali, Zoha, Kardia, Sharon L. R., Kavousi, Maryam, Kifley, Annette, Kiiskinen, Tuomo, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Liew, Gerald, van der Most, Peter J., Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, Medland, Sarah E., Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Milani, Lili, Missmer, Stacey A., Mitchell, Paul, Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, de Mutsert, Renée, Nauck, Matthias, Nolte, Ilja M., Noordam, Raymond, Penninx, Brenda W. J. H., Peters, Annette, Peyser, Patricia A., Polašek, Ozren, Power, Chris, Pribisalic, Ajka, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Shukla, Vallari, Smith, Jennifer A., Stankovic, Stasa, Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Swertz, Morris A., Teumer, Alexander, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Uitterlinden, André G., Waldenberger, Melanie, Wareham, Nicholas J., Weir, David R., Willemsen, Gonneke, Zhao, Jing Hau, Zhao, Wei, Zhao, Yajie, Snieder, Harold, den Hoed, Marcel, Ong, Ken K., Mills, Melinda C., Perry, John R. B.

Publikováno v: Nature Human Behaviour, 7(5), 790-801. Springer Nature
Nature Human Behaviour, 7(5), 790-801. Nature Publishing Group
eQTLGen Consortium, BIOS Consortium, FinnGen study & Lifelines Cohort Study 2023, ' Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus ', Nature Human Behaviour, vol. 7, no. 5, pp. 790-801 . https://doi.org/10.1038/s41562-023-01528-6
Mathieson, I, Day, F R, Barban, N, Tropf, F, Brazel, D M, Vaez, A, van Zuydam, N R, Bitarello, B, Davey Smith, G, McMahon, G, Mills, M C & Perry, J R B 2023, ' Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus ', Nature Human Behaviour, vol. 7, no. 5, pp. 790–801 . https://doi.org/10.1038/s41562-023-01528-6
Mathieson, I, Day, F R, Barban, N, Boomsma, D I, de Geus, E J C, Hottenga, J J, Jansen, R, Mbarek, H, Penninx, B W J H, Willemsen, G, Snieder, H, den Hoed, M, Ong, K K, Mills, M C, Perry, J R B, eQTLGen Consortium, BIOS Consortium, FinnGen Study & LifeLines Cohort Study 2023, ' Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus ', Nature Human Behaviour, vol. 7, no. 5, pp. 790-801 . https://doi.org/10.1038/s41562-023-01528-6
2023, ' Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus ', Nature Human Behaviour . https://doi.org/10.1038/s41562-023-01528-6
Mathieson, I, Day, F R, Barban, N, Tropf, F C, Brazel, D M, van Heemst, D, Vaez, A, van Zuydam, N, Bitarello, B D, Gardner, E J, Akimova, E T, Azad, A, Bergmann, S, Bielak, L F, Boomsma, D I, Bosak, K, Brumat, M, Buring, J E, Cesarini, D, Chasman, D I, Chavarro, J E, Cocca, M, Concas, M P, Davey Smith, G, Davies, G, Deary, I J, Esko, T, Faul, J D, Franco, O, Ganna, A, Gaskins, A J, Gelemanovic, A, de Geus, E J C, Gieger, C, Girotto, G, Gopinath, B, Grabe, H J, Gunderson, E P, Hayward, C, He, C, van Heemst, D, Hill, W D, Hoffmann, E R, Homuth, G, Hottenga, J J, Huang, H, Hyppӧnen, E, Ikram, M A, Møllegaard, S, Shukla, V, eQTLGen Consortium, BIOS Consortium, FinnGen Study & LifeLines Cohort Study 2023, ' Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus ', Nature Human Behaviour, vol. 7, 790–801 . https://doi.org/10.1038/s41562-023-01528-6

Refereed/Peer-reviewed Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1b462d80537f210cd0dbc59f8d3d7a
https://research.vu.nl/en/publications/9d4c5a89-fbff-44d1-a1a9-75509663bf72