Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Weiping J. Zhang"'
Autor:
Mingming Xing, Yang Li, Yuqi Zhang, Juemou Zhou, Danting Ma, Mengqi Zhang, Minglei Tang, Ting Ouyang, Fumiao Zhang, Xiaofeng Shi, Jianyuan Sun, Zuxin Chen, Weiping J. Zhang, Shuli Zhang, Xiangyang Xie
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The paraventricular hypothalamus (PVH) is crucial for food intake control, yet the presynaptic mechanisms underlying PVH neurons remain unclear. Here, we show that RUVBL2 in the PVH is significantly reduced during energy deficit, and knockou
Externí odkaz:
https://doaj.org/article/e355cb264c7f44cd8593ee4bc233abfe
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33278- (2024)
Arginase, an enzyme dependent on manganese (Mn), plays a crucial role in the production of urea and processing of ammonia in the liver. Previous studies have shown that overconsumption of fructose disrupts Mn homeostasis in the liver of male mice. Ho
Externí odkaz:
https://doaj.org/article/70c84fbbe1a549de8bad129ddb47ba1d
Autor:
Jian-Hui Shi, Yu-Xia Chen, Yingying Feng, Xiaohang Yang, Jie Lin, Ting Wang, Chun-Chun Wei, Xian-Hua Ma, Rui Yang, Dongmei Cao, Hai Zhang, Xiangyang Xie, Zhifang Xie, Weiping J. Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Arginase, a manganese (Mn)-dependent enzyme, is indispensable for urea generation and ammonia disposal in the liver. The potential role of fructose in Mn and ammonia metabolism is undefined. Here we demonstrate that fructose overconsumption
Externí odkaz:
https://doaj.org/article/014ff36b029a4ce38946bd821c2f6fce
Autor:
Jian Xiao, Le-Wei Dong, Shuai Liu, Fan-Hua Meng, Chang Xie, Xiao-Yi Lu, Weiping J. Zhang, Jie Luo, Bao-Liang Song
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is internalized via clathrin-mediated endocytosis and transported to e
Externí odkaz:
https://doaj.org/article/f8e1015e759a442db518284ebdf1b709
Publikováno v:
Chinese Medical Journal, Vol 134, Iss 11, Pp 1276-1285 (2021)
Abstract. Excessive consumption of fructose, the sweetest of all naturally occurring carbohydrates, has been linked to worldwide epidemics of metabolic diseases in humans, and it is considered an independent risk factor for cardiovascular diseases. W
Externí odkaz:
https://doaj.org/article/0386503c20af4d56889b1421852968a3
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Recent studies have shown that ZBTB20, a zinc-finger protein containing transcription factor, is highly expressed in small-diameter primary sensory neurons in mice, and modulates pain through regulating TRP channels. However, whether ZBTB20 regulates
Externí odkaz:
https://doaj.org/article/12f23b0701c641e8ad6df83ebc55f740
Autor:
Gan Liu, Luting Zhou, Hai Zhang, Rong Chen, Ye Zhang, Ling Li, Jun-Yu Lu, Hui Jiang, Dong Liu, Shasha Qi, Ying-Ming Jiang, Kai Yin, Zhifang Xie, Yuguang Shi, Yong Liu, Xuetao Cao, Yu-Xia Chen, Dajin Zou, Weiping J. Zhang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
De novo lipogenesis is tightly controlled by hormonal and nutritional signals and plays an important role in energy homoeostasis. Here, Liu et al. show that zinc finger protein ZBTB20 regulates the expression of key glycolytic and lipogenic genes by
Externí odkaz:
https://doaj.org/article/b81cc4076fdc4b64ab9d4bbb68641880
Autor:
Gan Liu, Jun-Nan Xu, Dong Liu, Qingli Ding, Meng-Na Liu, Rong Chen, Mengdi Fan, Ye Zhang, Chao Zheng, Da-Jin Zou, Jianxin Lyu, Weiping J. Zhang
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 7, Pp 1155-1161 (2016)
LPL is a pivotal rate-limiting enzyme to catalyze the hydrolysis of TG in circulation, and plays a critical role in regulating lipid metabolism. However, little attention has been paid to LPL in the adult liver due to its relatively low expression. H
Externí odkaz:
https://doaj.org/article/2758be3b4b5748c69eeca0fb04b7095d
Autor:
Dongmei Cao, Xianhua Ma, Jiao Cai, Jing Luan, An-Jun Liu, Rui Yang, Yi Cao, Xiaotong Zhu, Hai Zhang, Yu-Xia Chen, Yuguang Shi, Guang-Xia Shi, Dajin Zou, Xuetao Cao, Michael J. Grusby, Zhifang Xie, Weiping J. Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The pituitary is a complex structure with the anterior lobe containing five specialized cell types secreting different hormones. Here Cao et al. unravel a role for ZBTB20 in pituitary development and specifically in lactrotrope specification.
Externí odkaz:
https://doaj.org/article/7d92585d1fcf43e69c1f7145ec6e33f1
Autor:
Yawei Zhao, Qingyang Wang, Guihua Qiu, Silei Zhou, Zhaofei Jing, Jingyang Wang, Wendie Wang, Junxia Cao, Kun Han, Qianqian Cheng, Beifen Shen, Yingyu Chen, Weiping J. Zhang, Yuanfang Ma, Jiyan Zhang
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1407-1417 (2015)
Autophagy is essential for maintaining tissue homeostasis. Although adaptors have been demonstrated to facilitate the assembly of the Atg14L-Beclin 1-Vps34-Vps15 complex, which functions in autophagosome formation, it remains unknown whether the auto
Externí odkaz:
https://doaj.org/article/51b60e27956a4dd98adce8e459757626