Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Weiping J Zhang"'
Autor:
Mingming Xing, Yang Li, Yuqi Zhang, Juemou Zhou, Danting Ma, Mengqi Zhang, Minglei Tang, Ting Ouyang, Fumiao Zhang, Xiaofeng Shi, Jianyuan Sun, Zuxin Chen, Weiping J. Zhang, Shuli Zhang, Xiangyang Xie
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The paraventricular hypothalamus (PVH) is crucial for food intake control, yet the presynaptic mechanisms underlying PVH neurons remain unclear. Here, we show that RUVBL2 in the PVH is significantly reduced during energy deficit, and knockou
Externí odkaz:
https://doaj.org/article/e355cb264c7f44cd8593ee4bc233abfe
Autor:
Zhipeng Qu, Hai Zhang, Moli Huang, Guangsen Shi, Zhiwei Liu, Pancheng Xie, Hui Li, Wei Wang, Guoqiang Xu, Yang Zhang, Ling Yang, Guocun Huang, Joseph S Takahashi, Weiping J Zhang, Ying Xu
Publikováno v:
eLife, Vol 5 (2016)
Many animals display morning and evening bimodal activities in the day/night cycle. However, little is known regarding the potential components involved in the regulation of bimodal behavioral rhythms in mammals. Here, we identified that the zinc fin
Externí odkaz:
https://doaj.org/article/4a26c1f8a0f84f73a3aaca6c743daccd
Autor:
Huizhan Liu, Yi Li, Lei Chen, Qian Zhang, Ning Pan, David H Nichols, Weiping J Zhang, Bernd Fritzsch, David Z Z He
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168953 (2016)
Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the stria is responsible for generating the endocochlear potential (EP), which is the driving force
Externí odkaz:
https://doaj.org/article/fe0aa2741df0476eb6d1bf016aaeb996
Autor:
Yi Li, Huizhan Liu, Cody L Barta, Paul D Judge, Lidong Zhao, Weiping J Zhang, Shusheng Gong, Kirk W Beisel, David Z Z He
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151291 (2016)
Regulation of gene expression is essential to determining the functional complexity and morphological diversity seen among different cells. Transcriptional regulation is a crucial step in gene expression regulation because the genetic information is
Externí odkaz:
https://doaj.org/article/bf76ec4af1ea4ca9b77ffdd5eb6e63e3
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33278- (2024)
Arginase, an enzyme dependent on manganese (Mn), plays a crucial role in the production of urea and processing of ammonia in the liver. Previous studies have shown that overconsumption of fructose disrupts Mn homeostasis in the liver of male mice. Ho
Externí odkaz:
https://doaj.org/article/70c84fbbe1a549de8bad129ddb47ba1d
Autor:
Jian-Hui Shi, Yu-Xia Chen, Yingying Feng, Xiaohang Yang, Jie Lin, Ting Wang, Chun-Chun Wei, Xian-Hua Ma, Rui Yang, Dongmei Cao, Hai Zhang, Xiangyang Xie, Zhifang Xie, Weiping J. Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Arginase, a manganese (Mn)-dependent enzyme, is indispensable for urea generation and ammonia disposal in the liver. The potential role of fructose in Mn and ammonia metabolism is undefined. Here we demonstrate that fructose overconsumption
Externí odkaz:
https://doaj.org/article/014ff36b029a4ce38946bd821c2f6fce
Autor:
Jian Xiao, Le-Wei Dong, Shuai Liu, Fan-Hua Meng, Chang Xie, Xiao-Yi Lu, Weiping J. Zhang, Jie Luo, Bao-Liang Song
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is internalized via clathrin-mediated endocytosis and transported to e
Externí odkaz:
https://doaj.org/article/f8e1015e759a442db518284ebdf1b709
Autor:
Zhenbang Qin, Ping Wang, Weiwen Chen, Jue-Rui Wang, Xianhua Ma, Hai Zhang, Weiping J. Zhang, Chunchun Wei
Publikováno v:
Biochemical and Biophysical Research Communications. 658:128-135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e465cec927210a7f29d4b8be140ca951
https://doi.org/10.1016/j.bbrc.2023.03.075
https://doi.org/10.1016/j.bbrc.2023.03.075
Autor:
Yiruo Ma, Siyi Shen, Ying Yan, Shengjie Zhang, Shengnan Liu, Zhili Tang, Jing Yu, Mei Ma, Zhoumin Niu, Zhuoyang Li, Yuting Wu, Lin Zhao, Zhiqiang Lu, Chunchun Wei, Weiping J. Zhang, Ying Xue, Qiwei Zhai, Yu Li, Cheng Hu, Jingjing Jiang, Yuying Li, Hao Ying
Publikováno v:
Diabetes. 72:562-574
Thyroid hormone (TH) has a profound effect on energy metabolism and systemic homeostasis. Adipose tissues are crucial for maintaining whole-body homeostasis; however, whether TH regulates systemic metabolic homeostasis through its action on adipose t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86a23bbabe6bc038d05a82000738df5e
https://doi.org/10.2337/db22-0656
https://doi.org/10.2337/db22-0656
Autor:
Qiufang Bai, Yajin Liu, Chen-Ma Wang, Jue-Rui Wang, Yingying Feng, Xianhua Ma, Xiaohang Yang, Ya-Nan Shi, Weiping J Zhang
Publikováno v:
Endocrinology. 164
Fructose intolerance in mammals is caused by defects in fructose absorption and metabolism. Fructose-1,6-bisphosphatase 1 (FBP1) is a key enzyme in gluconeogenesis, and its deficiency results in hypoglycemia as well as intolerance to fructose. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::678f5e81bbb66fb3765cd530537cb0d3
https://doi.org/10.1210/endocr/bqad054
https://doi.org/10.1210/endocr/bqad054