Systematic mutational analysis of the LytTR DNA binding domain of Staphylococcus aureus virulence gene transcription factor AgrA

Autor: Nicod, SS, Weinzierl, RO, Burchell, L, Escalera-Maurer, A, James, EH, Wigneshweraraj, S

Most DNA-binding bacterial transcription factors contact DNA through a recognition α-helix in their DNA-binding domains. An emerging class of DNA-binding transcription factors, predominantly found in pathogenic bacteria interact with the DNA via a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::855d3b3e52115300b8a5b1c142a93478
http://hdl.handle.net/10044/1/18235

The nucleotide addition cycle of RNA polymerase is controlled by two molecular hinges in the Bridge Helix domain

Autor: Weinzierl Robert OJ

Publikováno v: BMC Biology, Vol 8, Iss 1, p 134 (2010)

Abstract Background Cellular RNA polymerases (RNAPs) are complex molecular machines that combine catalysis with concerted conformational changes in the active center. Previous work showed that kinking of a hinge region near the C-terminus of the Brid

Externí odkaz: https://doaj.org/article/5db36940400a40c5bc2451b3f22027d2

Molecular Dynamics of "Fuzzy" Transcriptional Activator-Coactivator Interactions.

Autor: Scholes NS; Imperial College London, Department of Life Sciences, London, United Kingdom., Weinzierl RO; Imperial College London, Department of Life Sciences, London, United Kingdom.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2016 May 13; Vol. 12 (5), pp. e1004935. Date of Electronic Publication: 2016 May 13 (Print Publication: 2016).

Systematic mutational analysis of the LytTR DNA binding domain of Staphylococcus aureus virulence gene transcription factor AgrA.

Autor: Nicod SS; MRC Centre for Molecular Microbiology and Infection, Imperial College London, London, UK., Weinzierl RO; Department of Life Sciences, Imperial College London, London, UK., Burchell L; MRC Centre for Molecular Microbiology and Infection, Imperial College London, London, UK., Escalera-Maurer A; Department of Life Sciences, Imperial College London, London, UK., James EH; MRC Centre for Molecular Microbiology and Infection, Imperial College London, London, UK., Wigneshweraraj S; MRC Centre for Molecular Microbiology and Infection, Imperial College London, London, UK s.r.wig@imperial.ac.uk.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2014 Nov 10; Vol. 42 (20), pp. 12523-36. Date of Electronic Publication: 2014 Oct 28.

An aromatic residue switch in enhancer-dependent bacterial RNA polymerase controls transcription intermediate complex activity.

Autor: Wiesler SC; Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK. s.wiesler@imperial.ac.uk, Weinzierl RO, Buck M

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2013 Jun; Vol. 41 (11), pp. 5874-86. Date of Electronic Publication: 2013 Apr 22.