Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Weining Yin"'
Autor:
Weining Yin, Junting Yao, Xuwei Leng, Chengbang Ma, Xiaoling Chen, Yangyang Jiang, Tao Wang, Tianbao Chen, Chris Shaw, Mei Zhou, Lei Wang
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1098 (2024)
Antibiotic resistance poses a serious threat to public health globally, reducing the effectiveness of conventional antibiotics in treating bacterial infections. ESKAPE pathogens are a group of highly transmissible bacteria that mainly contribute to t
Externí odkaz:
https://doaj.org/article/ba36cd16f7284bf3869172d63390aded
Autor:
Weining Yin, Hannah L. Golliher, Amy J. Ferguson, Julia S. Kimbell, Alessandra Livraghi-Butrico, Troy D. Rogers, Barbara R. Grubb, Adam J. Kimple, Lawrence E. Ostrowski
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: Genetic defects in motile cilia cause primary ciliary dyskinesia (PCD), a rare disease with no specific therapeutics. Individuals with PCD often have impaired fertility and laterality defects and universally suffer from upper and lower ai
Externí odkaz:
https://doaj.org/article/7313cb29e11040f7ab3ac56f34fb3ca2
Autor:
Junting Yao, Weining Yin, Yuqing Chen, Xiaoling Chen, Yangyang Jiang, Tao Wang, Chengbang Ma, Mei Zhou, Tianbao Chen, Chris Shaw, Lei Wang
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1805 (2022)
Cationic cell-penetrating peptides (CPPs), such as transactivator of transcription (TAT) peptide, have been proposed as effective drug carriers to improve intracellular delivery of biological macromolecules. Amphibian skin-derived Kunitz-type trypsin
Externí odkaz:
https://doaj.org/article/890b4398b09f4f9f8064b84ec09623e6
Autor:
Lawrence E. Ostrowski, Weining Yin, Amanda J. Smith, Patrick R. Sears, Ximena M. Bustamante-Marin, Hong Dang, Friedhelm Hildebrandt, Leigh Anne Daniels, Nicole A. Capps, Kelli M. Sullivan, Margaret W. Leigh, Maimoona A. Zariwala, Michael R. Knowles
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1753 (2022)
Primary ciliary dyskinesia (PCD) is a rare lung disease caused by mutations that impair the function of motile cilia, resulting in chronic upper and lower respiratory disease, reduced fertility, and a high prevalence of situs abnormalities. The disea
Externí odkaz:
https://doaj.org/article/4b3988c221d24482b992cdf7a4bd437e
Autor:
Jianfeng Lin, Michael R. Knowles, L.A. Daniels, Lawrence E. Ostrowski, Patrick R. Sears, Yanhe Zhao, Maimoona A. Zariwala, Justine M Pinskey, Weining Yin, Daniela Nicastro
Publikováno v:
Molecular Biology of the Cell. 32:1202-1209
A growing number of ciliopathy-associated genes have been identified, but how they cause ciliary dysfunction is often unclear. Using cryo-electron tomography, we characterize the structural defects in patient cilia lacking radial spoke protein RSPH4A
Autor:
Wanda K. O'Neal, Rhianna E. Lee, Teresa M. Mascenik, Takanori Asakura, Hong Dang, Lisa C. Morton, Barbara R. Grubb, Hirotoshi Matsui, Martina Gentzsch, Richard C. Boucher, Carlton W Anderson, Kenichi Okuda, Gang Chen, Purushothama Rao Tata, Yvonne K. O’Neal, Satoko Nakano, Takahide Nagase, Yoshihiko Kobayashi, Michael Chua, Selene Margarita Barbosa Cardenas, Nancy L. Quinney, John C. Olsen, Andrew J. Ghio, Gianni Carraro, Caroline E Minnick, Lawrence E. Ostrowski, Rodney C. Gilmore, Takafumi Kato, Scott H. Randell, Barry R. Stripp, Weining Yin
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 203:1275-1289
Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF] transmembrane conductance regulator) is required for precision medicine therapies for CF. However, a full ...
Autor:
Amanda J. Smith, Ximena M. Bustamante-Marin, Weining Yin, Patrick R. Sears, Laura E. Herring, Nedyalka N. Dicheva, Francesc López-Giráldez, Shrikant Mane, Robert Tarran, Margaret W. Leigh, Michael R. Knowles, Maimoona A. Zariwala, Lawrence E. Ostrowski
Publikováno v:
J Cell Sci
Mutations in SPAG1, a dynein axonemal assembly factor (DNAAF) that facilitates the assembly of dynein arms in the cytoplasm before their transport into the cilium, result in primary ciliary dyskinesia (PCD), a genetically heterogenous disorder charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeab5942164794e7c4adf5113a871d7e
https://europepmc.org/articles/PMC8995097/
https://europepmc.org/articles/PMC8995097/
Autor:
Lawrence E, Ostrowski, Weining, Yin, Amanda J, Smith, Patrick R, Sears, Ximena M, Bustamante-Marin, Hong, Dang, Friedhelm, Hildebrandt, Leigh Anne, Daniels, Nicole A, Capps, Kelli M, Sullivan, Margaret W, Leigh, Maimoona A, Zariwala, Michael R, Knowles
Publikováno v:
International journal of molecular sciences. 23(3)
Primary ciliary dyskinesia (PCD) is a rare lung disease caused by mutations that impair the function of motile cilia, resulting in chronic upper and lower respiratory disease, reduced fertility, and a high prevalence of situs abnormalities. The disea
Autor:
Troy D. Rogers, Weining Yin, Alessandra Livraghi-Butrico, Lawrence E. Ostrowski, Kimberlie A. Burns, Barbara R. Grubb, Patrick R. Sears
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 61:312-321
Primary ciliary dyskinesia (PCD) is a genetically and phenotypically heterogeneous disease caused by mutations in over 40 different genes. Individuals with PCD caused by mutations in RSPH1 (radial ...
Autor:
Yanhe, Zhao, Justine, Pinskey, Jianfeng, Lin, Weining, Yin, Patrick R, Sears, Leigh A, Daniels, Maimoona A, Zariwala, Michael R, Knowles, Lawrence E, Ostrowski, Daniela, Nicastro
Publikováno v:
Molecular Biology of the Cell
Cilia and flagella are evolutionarily conserved eukaryotic organelles involved in cell motility and signaling. In humans, mutations in Radial Spoke Head Component 4A (RSPH4A) can lead to primary ciliary dyskinesia (PCD), a life-shortening disease cha