Výsledky vyhledávání

Akademický článek

Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D 3 Dopamine Receptor Agonist.

Autor: Moritz AE; Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, 35 Convent Drive, MSC-3723, Bethesda, Maryland 20892-3723, United States., Free RB; Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, 35 Convent Drive, MSC-3723, Bethesda, Maryland 20892-3723, United States., Weiner WS; University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, Kansas 66047, United States., Akano EO; Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, 35 Convent Drive, MSC-3723, Bethesda, Maryland 20892-3723, United States., Gandhi D; Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Abramyan A; Computational Chemistry and Molecular Biophysics Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Keck TM; Department of Chemistry & Biochemistry, Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States., Ferrer M; NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Hu X; NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Southall N; NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Steiner J; NeuroTherapeutics Development Unit, National Institute for Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, United States., Aubé J; University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, Kansas 66047, United States.; Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Shi L; Computational Chemistry and Molecular Biophysics Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Frankowski KJ; University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, Kansas 66047, United States.; Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Sibley DR; Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, 35 Convent Drive, MSC-3723, Bethesda, Maryland 20892-3723, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 May 28; Vol. 63 (10), pp. 5526-5567. Date of Electronic Publication: 2020 May 12.

Zobrazit plný text záznamu

Akademický článek

Revisiting the β-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach.

Autor: Xiao S; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Guo H; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Weiner WS; Specialized Chemistry Center, University of Kansas, Lawrence, Kansas, USA., Maddox C; Southern Research Molecular Libraries Screening Center, Southern Research Institute, Birmingham, Alabama, USA., Mao C; Biocomplexity Institute and Initiative, University of Virginia, Charlottesville, Virginia, USA., Gunosewoyo H; School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Western Australia, Australia., Pelly S; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., White EL; Southern Research Molecular Libraries Screening Center, Southern Research Institute, Birmingham, Alabama, USA., Rasmussen L; Southern Research Molecular Libraries Screening Center, Southern Research Institute, Birmingham, Alabama, USA., Schoenen FJ; Specialized Chemistry Center, University of Kansas, Lawrence, Kansas, USA.; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, USA., Aubé J; Specialized Chemistry Center, University of Kansas, Lawrence, Kansas, USA.; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, USA., Bishai WR; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Lun S; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA slun1@jhmi.edu.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Oct 22; Vol. 63 (11). Date of Electronic Publication: 2019 Oct 22 (Print Publication: 2019).

Zobrazit plný text záznamu

Akademický článek

Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.

Autor: Flaherty DP; University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66049, USA.; Present Address: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 West Stadium Avenue, West Lafayette, IN, 47907, USA., Harris MT; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA.; Present Address: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Schroeder CE; University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66049, USA., Khan H; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA., Kahney EW; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA.; Present Address: Department of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA., Hackler AL; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA., Patrick SL; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA., Weiner WS; University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66049, USA., Aubé J; University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66049, USA.; Present Address: School of Pharmacy, University of North Carolina, 3012 Marsico Hall, 125 Mason Farm Road, Chapel Hill, NC, 27599, USA., Sharlow ER; Department of Pharmacology, University of Virginia, Charlottesville, VA, 22908, USA., Morris JC; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA., Golden JE; University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66049, USA.; Present Address: School of Pharmacy, Department of Pharmaceutical Sciences, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI, 53705, USA.

Publikováno v: ChemMedChem [ChemMedChem] 2017 Dec 07; Vol. 12 (23), pp. 1994-2005. Date of Electronic Publication: 2017 Nov 16.

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání