Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Weina Shang"'
Autor:
Caixia Zhou, Zhirong Li, Yawen Li, Yaoyao Li, Wei Wang, Weina Shang, Jun-Ping Liu, Liquan Wang, Chao Tong
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114304- (2024)
Summary: High TRABD expression is associated with tau pathology in patients with Alzheimer’s disease; however, the function of TRABD is unknown. Human TRABD encodes a mitochondrial outer-membrane protein. The loss of TRABD resulted in mitochondrial
Externí odkaz:
https://doaj.org/article/e3462f15a1ec49ca95ca6880481ea4e2
Publikováno v:
eLife, Vol 9 (2020)
Endoplasmic reticulum (ER)–mitochondria contact sites (ERMCSs) are crucial for multiple cellular processes such as calcium signaling, lipid transport, and mitochondrial dynamics. However, the molecular organization, functions, regulation of ERMCS,
Externí odkaz:
https://doaj.org/article/85c1d8a5baa64f26837d232b49243c89
Autor:
Xuejun Tian, Upasana Gala, Yongping Zhang, Weina Shang, Sonal Nagarkar Jaiswal, Alberto di Ronza, Manish Jaiswal, Shinya Yamamoto, Hector Sandoval, Lita Duraine, Marco Sardiello, Roy V Sillitoe, Kartik Venkatachalam, Hengyu Fan, Hugo J Bellen, Chao Tong
Publikováno v:
PLoS Biology, Vol 13, Iss 3, p e1002103 (2015)
Autophagy helps deliver sequestered intracellular cargo to lysosomes for proteolytic degradation and thereby maintains cellular homeostasis by preventing accumulation of toxic substances in cells. In a forward mosaic screen in Drosophila designed to
Externí odkaz:
https://doaj.org/article/b0069c4576aa4ba5bcc4ed8cca6037a1
Autor:
Yinlu Deng, Weina Shang, Xiaomin Zhang, Jiansheng Guo, Yaqin Wang, Zhongkai Zhang, Jian Hong, Zhenghe Li, Li Xie
Publikováno v:
Micron. 166:103413
Publikováno v:
Journal of biochemical and molecular toxicologyREFERENCES. 36(8)
Dioscin is a natural product that possesses protective effects on multiple chronic injuries, but its effects on asthma are not fully understood. Herein, we evaluated its effects on asthmatic mice established by ovalbumin (OVA) sensitization and chall
Autor:
Xiaojie Ma, Yunkun Lu, Ziyu Zhou, Qin Li, Xi Chen, Weiyun Wang, Yan Jin, Zhensheng Hu, Guo Chen, Qian Deng, Weina Shang, Hao Wang, Hongxing Fu, Xiangwei He, Xin-Hua Feng, Saiyong Zhu
Publikováno v:
Science advances. 8(8)
An unlimited source of human pancreatic β cells is in high demand. Even with recent advances in pancreatic differentiation from human pluripotent stem cells, major hurdles remain in large-scale and cost-effective production of functional β cells. H
Publikováno v:
Cell Death Differ
Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine. P5CS malfunction leads to multiple human diseases; however, the molecular mechanism underlyi
Autor:
Weina Shang, Jun-Ping Liu, Liquan Wang, Chun-Hong Chen, Xiuying Duan, Jian-Chiuan Li, Jiayao Zhao, Wei Liu, Lingna Xu, Chao Tong
Publikováno v:
Cell Death Differ
The mitochondrion is a highly dynamic organelle that is critical for energy production and numerous metabolic processes. Drosophila Chchd2, a homolog of the human disease-related genes CHCHD2 and CHCHD10, encodes a mitochondrial protein. In this stud
Autor:
Lingna Xu, Yunyi Qiu, Xufeng Wang, Weina Shang, Jian Bai, Kexin Shi, Hao Liu, Jun-Ping Liu, Liquan Wang, Chao Tong
Publikováno v:
Cell Reports. 41:111583
Mitochondrial malfunction and autophagy defects are often concurrent phenomena associated with neurodegeneration. We show that Miga, a mitochondrial outer-membrane protein that regulates endoplasmic reticulum-mitochondrial contact sites (ERMCSs), is
Regulation of Lipid Homeostasis by the TBC Protein dTBC1D22 Via Modulation of the Small GTPase Rab40
Autor:
Xiuying Duan, Vafa Bayat, Wei Liu, Lingna Xu, Lijun Jia, Chao Tong, Wenxia Shao, Weina Shang, Yawen Li, Liquan Wang
Publikováno v:
SSRN Electronic Journal.
Lipid homeostasis is essential to cells. However, its regulation is not well understood. Using forward genetic screen, we demonstrated that the loss of CG5745, an essential gene in Drosophila that encodes a Tre2–Bub2–Cdc16 (TBC) domain-containing