Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Weiming Ouyang"'
Autor:
Chunling Gao, Weiming Ouyang, Joseph Kutza, Tobias A. Grimm, Karen Fields, Carla S. R. Lankford, Franziska Schwartzkopff, Mark Paciga, Tzanko Stantchev, Linda Tiffany, Klaus Strebel, Kathleen A. Clouse
Publikováno v:
Viruses, Vol 15, Iss 11, p 2160 (2023)
Human immunodeficiency virus type 2 (HIV-2) is known to be less pathogenic than HIV-1. However, the mechanism(s) underlying the decreased HIV-2 pathogenicity is not fully understood. Herein, we report that β-chemokine CCL2 expression was increased i
Externí odkaz:
https://doaj.org/article/bdefd4290afa43b6b1622a3b499a040c
Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics
Publikováno v:
Toxins, Vol 15, Iss 9, p 528 (2023)
Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET). PA binds c
Externí odkaz:
https://doaj.org/article/69fde52c7f454a98af1800f8f613cc2b
Publikováno v:
Bio-Protocol, Vol 4, Iss 13 (2014)
Antigen-specific killing ability of effector CD8+ T cells is critical for protective immunity against infection. Here, we describe in vivo cytotoxic T cell assay to examine effector function of antigen-specific CD8+ T cells. Mice infected with Lister
Externí odkaz:
https://doaj.org/article/1319faac27974b1286c25c02d08ab360
Publikováno v:
Bio-Protocol, Vol 4, Iss 13 (2014)
Upon pathogen encounter, naïve CD8+ T cells are primed and undergo massive clonal expansion. A fraction of effector CD8+ T cells remains during the contraction phase and differentiate into memory T cells critical for mounting robust recall responses
Externí odkaz:
https://doaj.org/article/2b9dc8a4697b4455a15f381fc9cb544e
Publikováno v:
Genomics Data, Vol 2, Iss C, Pp 280-281 (2014)
The Forkhead box O (Foxo) family of transcription factors has a critical role in controlling the development, differentiation, and function of T cells. However, the direct target genes of Foxo transcription factors in T cells have not been well chara
Externí odkaz:
https://doaj.org/article/491e7ef5aee04f07a362ef7a3fa7dcf5
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66943 (2013)
The scientific community has been restricted by the lack of a practical and informative animal model of gastrointestinal infection with vegetative Bacillus anthracis. We herein report the development of a murine model of gastrointestinal anthrax infe
Externí odkaz:
https://doaj.org/article/875c123228634e03bc0f917e3b83e803
Publikováno v:
Proc Natl Acad Sci U S A
Anthrax lethal toxin (LT) is a protease virulence factor produced by Bacillus anthracis that is required for its pathogenicity. LT treatment causes a rapid degradation of c-Jun protein that follows inactivation of the MEK1/2-Erk1/2 signaling pathway.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1703e64e86a5cc7fa9c047b9cea9ad
https://doi.org/10.1073/pnas.1913698117
https://doi.org/10.1073/pnas.1913698117
Autor:
Kang Chen, Meiyu Shen, Cyrus Agarabi, Meng-Jung Chiang, Patrick Lynch, Weiming Ouyang, Faruk Sheikh, Sharadrao M. Patil, Ankit B. Shah, Raymond P. Donnelly, Kurt Brorson, Hui Fang, Sarah Rogstad, Phillip Angart, David M. Frucht, Sarah J. Schrieber, Ashwinkumar A. Bhirde, Tao Xie, Kristina E. Howard
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
PEGylated recombinant human granulocyte colony stimulating factor (pegfilgrastim) is used clinically to accelerate immune reconstitution following chemotherapy and is being pursued for biosimilar development. One challenge to overcome in pegfilgrasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe45b4fa2041b60abacd838f0477ced2
http://link.springer.com/article/10.1038/s41598-020-59346-z
http://link.springer.com/article/10.1038/s41598-020-59346-z
Publikováno v:
2021 7th International Conference on Systems and Informatics (ICSAI).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812cb7b585c7884fb2cc193b8a651ead
https://doi.org/10.1109/icsai53574.2021.9664158
https://doi.org/10.1109/icsai53574.2021.9664158
Autor:
Weiming Ouyang, David M. Frucht, chunling gao, tongzhong ju, Tao Xie, kun yuan, Kathleen A. Clouse, Tzanko Stantchev, Hui Fang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7540, p 7540 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences
Volume 22
Issue 14
Proinflammatory cytokine production following infection with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is associated with poor clinical outcomes. Like SARS CoV-1, SARS CoV-2 enters host cells via its spike protein, which attaches t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c765c94cd202caf180f3bd23d628be
https://www.mdpi.com/1422-0067/22/14/7540
https://www.mdpi.com/1422-0067/22/14/7540