Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Weimei Xing"'
Publikováno v:
Exploration of Medicine, Vol 4, Iss 4, Pp 541-559 (2023)
Abnormal energy metabolism is one of the ten hallmarks of tumors, and tumor cell metabolism provides energy and a suitable microenvironment for tumorigenesis and metastasis. Tumor cells can consume large amounts of glucose and produce large amounts o
Externí odkaz:
https://doaj.org/article/404b70041f43494fbf7aa1979c67c206
Autor:
Weimei Xing, Ona Barauskas, Thorsten Kirschberg, Anita Niedziela-Majka, Michael Clarke, Gabriel Birkus, Perry Weissburg, Xiaohong Liu, Brian E Schultz, Roman Sakowicz, HyockJoo Kwon, Joy Y Feng
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181969 (2017)
Influenza polymerase is a heterotrimer composed of polymerase acidic protein A (PA) and basic proteins 1 (PB1) and 2 (PB2). The endonuclease active site, located in the PA subunit, cleaves host mRNA to prime viral mRNA transcription, and is essential
Externí odkaz:
https://doaj.org/article/214d6c14bef247f8a2cf1c7bae8f111c
Autor:
Ona Barauskas, Weimei Xing, Esmeralda Aguayo, Madeleine Willkom, Annapurna Sapre, Michael Clarke, Gabriel Birkus, Brian E Schultz, Roman Sakowicz, HyockJoo Kwon, Joy Y Feng
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185998 (2017)
Influenza polymerase is a heterotrimer protein with both endonuclease and RNA-dependent RNA polymerase (RdRp) activity. It plays a critical role in viral RNA replication and transcription and has been targeted for antiviral drug development. In this
Externí odkaz:
https://doaj.org/article/8ed1d422bf5149b8833aef2a4805c888
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146835 (2016)
GS-9620 is an orally administered agonist of Toll-like receptor (TLR)7 currently being evaluated in clinical studies for the treatment of chronic HBV and HIV patients. GS-9620 has shown antiviral efficacy in preclinical models of chronic hepadnavirus
Externí odkaz:
https://doaj.org/article/614c72cf65bd4b8e82dac2d05eb70dd6
Autor:
Hyock Joo Kwon, Weimei Xing, Katie Chan, Anita Niedziela-Majka, Katherine M Brendza, Thorsten Kirschberg, Darryl Kato, John O Link, Guofeng Cheng, Xiaohong Liu, Roman Sakowicz
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122844 (2015)
Ledipasvir, a direct acting antiviral agent (DAA) targeting the Hepatitis C Virus NS5A protein, exhibits picomolar activity in replicon cells. While its mechanism of action is unclear, mutations that confer resistance to ledipasvir in HCV replicon ce
Externí odkaz:
https://doaj.org/article/2ec4378953f54de7b0076a7adeb703bd
Autor:
Karin Regnström, Jiangli Yan, Lan Nguyen, Kari Callaway, Yanli Yang, Linnea Diep, Weimei Xing, Anirban Adhikari, Paul Beroza, Roy K Hom, Brigit Riley, Don Rudolph, Michael F Jobling, Jeanne Baker, Jennifer Johnston, Andrei Konradi, Michael P Bova, Dean R Artis
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e66879 (2013)
Surface Plasmon Resonance (SPR) is rarely used as a primary High-throughput Screening (HTS) tool in fragment-based approaches. With SPR instruments becoming increasingly high-throughput it is now possible to use SPR as a primary tool for fragment fin
Externí odkaz:
https://doaj.org/article/49e73ef974d742cb8de3fc7bf2fab6d1
Autor:
Karin Regnström, Jiangli Yan, Lan Nguyen, Kari Callaway, Yanli Yang, Linnea Diep, Weimei Xing, Anirban Adhikari, Paul Beroza, Roy K. Hom, Brigit Riley, Don Rudolph, Michael F. Jobling, Jeanne Baker, Jennifer Johnston, Andrei Konradi, Michael P. Bova, Dean R. Artis
Publikováno v:
PLoS ONE, Vol 8, Iss 7 (2013)
Externí odkaz:
https://doaj.org/article/35a65012167b4ec79e99546bbcc2addb
Autor:
Adele Wang, Lance Stapleton, Jean-Philippe Belzie, Weimei Xing, Gladys Muiru, Dmytro Kornyeyev, Edward Hsieh, Albert Liclican, Pamela Toy, Mengshu Xu, Kei Kim, Jacob Lee, Michelle Kuhne, Latesh Lad
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Jacob S. Lee, Pamela Toy, Gundula Min-Oo, Tony Lee, Patrick Salvo, JeanPhilippe Belzile, Sheila Clancy, Jonathan Nazareno, Mengshu Xu, Weimei Xing, Marilyn Giacomini, Rex Santos, Lance Stapleton, Adele Wang, Vladislava Juric, Scott A. Mitchell, Michelle Kuhne
Publikováno v:
Cancer Research. 82:3517-3517
Hematopoietic progenitor kinase 1 (HPK1, mitogen-activated kinase kinase kinase kinase 1 [MAP4K1]), a cytosolic STE20 ser/thr kinase from the germinal center family of kinases, regulates the function of diverse immune populations including T cells, B
Autor:
Martin Hubálek, Dhivya Ramakrishnan, Rudolf K. F. Beran, Saketh Chemuru, Henry W. Rohrs, Hyock Joo Kwon, Upasana Mehra, Weimei Xing, Iva Pichová, Michael L. Gross, Bruno Marchand, Michal Doležal, Anita Niedziela-Majka, Aleš Zábranský, Simon P. Fletcher
Publikováno v:
Journal of Virology
The structural maintenance of chromosomes 5/6 complex (Smc5/6) is a host restriction factor that suppresses HBV transcription. HBV counters this restriction by expressing HBV X protein (HBx), which redirects a host ubiquitin ligase to target Smc5/6 f