Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Weilin Xie"'
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-3 (2024)
Abstract Protein degraders, emerging as a novel class of therapeutic agents, have gained widespread attention due to their advantages. They have several advantages over traditional small molecule inhibitors, including high target selectivity and abil
Externí odkaz:
https://doaj.org/article/8b30f77a46814519b78041db3c7a6291
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectivesThis study aims to assess the efficacy of tofacitinib (TOF) plus iguratimod (IGU) in rheumatoid arthritis (RA) with usual interstitial pneumonia (UIP) (RA-UIP).MethodsThis was a prospective observational cohort, single-center study. Data fr
Externí odkaz:
https://doaj.org/article/6163931f435e4ca3a93cef2d255309e9
Publikováno v:
IEEE Photonics Journal, Vol 15, Iss 1, Pp 1-6 (2023)
We present a time-stable receiving system for broadband signals transmitted via a 25 km fiber optic link. The timing jitter of the signal induced by the transmission link is precisely eliminated after the signal is digitized with a dithered sample cl
Externí odkaz:
https://doaj.org/article/3fca61dfa50048839e77565128c49b46
Autor:
Yinxia Meng, Weilin Xie, Yuxiang Feng, Jiang Yang, Ling Zhang, Yuanshuo Bai, Wei Wei, Yi Dong
Publikováno v:
IEEE Photonics Journal, Vol 13, Iss 4, Pp 1-7 (2021)
We report on a dynamic range enhanced optical frequency domain reflectometry distributed backscattering interrogator based on dual-loop composite optical phase-locked loop (OPLL). Exploiting simultaneously an acousto-optic frequency shifter based an
Externí odkaz:
https://doaj.org/article/bf2adb3a5fed482f84664f9ff3e5b2e1
Autor:
Huajie Li, Zhenjie Yu, Haoyi Sun, Bo Liu, Xin Wang, Zhe Shao, Meiling Wang, Weilin Xie, Xingang Yao, Qingqiang Yao, Ying Zhi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yield
Externí odkaz:
https://doaj.org/article/e1d57115ab0d48e3a5d53e95bf71612a
Autor:
Thomas B. Layton, Lynn Williams, Fiona McCann, Mingjun Zhang, Marco Fritzsche, Huw Colin-York, Marisa Cabrita, Michael T. H. Ng, Marc Feldmann, Stephen N. Sansom, Dominic Furniss, Weilin Xie, Jagdeep Nanchahal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
New anti-fibrotics aided by a better understanding of fibrotic cell subsets and their functions are needed. Here the authors perform single-cell RNA-seq and CyTOF on nodules from patients with Dupuytren’s disease to map subsets and the state of mes
Externí odkaz:
https://doaj.org/article/7e67ad4ab04e40f987c55274c1eafb3b
Autor:
Ling Zhang, Weilin Xie, Yuxiang Feng, Zhangweiyi Liu, Haijun Zhou, Yinxia Meng, Yuanshuo Bai, Wei Wei, Yi Dong
Publikováno v:
IEEE Photonics Journal, Vol 12, Iss 3, Pp 1-11 (2020)
Understanding the effects of laser phase and frequency noise on laser interferometry is significant for evaluating the system performance. To precisely study the performance limit caused by laser frequency noise, here we propose and demonstrate a ver
Externí odkaz:
https://doaj.org/article/8400a6693f64415fae21231274c3ac8c
Autor:
Xiaocheng Wang, Wei Wei, Zhangweiyi Liu, Daming Han, Nan Deng, Lingwei Yang, Weilin Xie, Yi Dong
Publikováno v:
IEEE Photonics Journal, Vol 11, Iss 2, Pp 1-8 (2019)
We demonstrate a simultaneous frequency and time reference dissemination system over 80 km fiber with a phase-locked loop. The phase fluctuation of the transferred radio-frequency (RF) signal is compensated by adjusting the frequency of the voltage-c
Externí odkaz:
https://doaj.org/article/d814cc7023d8460290eb8b62cbc04364
Autor:
Thomas B. Layton, Lynn Williams, Huw Colin-York, Fiona E. McCann, Marisa Cabrita, Marc Feldmann, Cameron Brown, Weilin Xie, Marco Fritzsche, Dominic Furniss, Jagdeep Nanchahal
Publikováno v:
Biology Open, Vol 9, Iss 3 (2020)
Mechanical force is a fundamental regulator of cell phenotype. Myofibroblasts are central mediators of fibrosis, a major unmet clinical need characterised by the deposition of excessive matrix proteins. Traction forces of myofibroblasts play a key ro
Externí odkaz:
https://doaj.org/article/d52f174eb2eb475380dde359b74ce9ac
Autor:
Mingjun Zhang, Michael Haughey, Nai-Yu Wang, Kate Blease, Ann M Kapoun, Suzana Couto, Igor Belka, Timothy Hoey, Matthew Groza, James Hartke, Brydon Bennett, Jennifer Cain, Austin Gurney, Brent Benish, Paola Castiglioni, Clifton Drew, Jean Lachowicz, Leon Carayannopoulos, Steven D Nathan, Jorg Distler, David A Brenner, Kandasamy Hariharan, Ho Cho, Weilin Xie
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229445 (2020)
The Wnt/β-catenin signaling pathway has been implicated in human proliferative diseases such as cancer and fibrosis. The functions of β-catenin and several other components of this pathway have been investigated in fibrosis. However, the potential
Externí odkaz:
https://doaj.org/article/0d7f69de1072458fb78965ae68d70c9c