Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Weikun Xia"'
Autor:
Wei Xie, Weikun Xia
Publikováno v:
Stem Cell Reports
Summary Upon fertilization, terminally differentiated gametes are transformed to a totipotent zygote, which gives rise to an embryo. How parental epigenetic memories are inherited and reprogrammed to accommodate parental-to-zygotic transition remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0038525274fff3f3817544216bf0f9
http://europepmc.org/articles/PMC7724468
http://europepmc.org/articles/PMC7724468
Autor:
Yu Zhang, Zili Lin, Xukun Lu, Weikun Xia, Feng Kong, Huili Wang, Lijuan Wang, Si-Nan Ma, Chaolei Chen, Ling Liu, Wei Xie, Wei Li, Hemin Ni, Leyun Wang, Yong Guo, Xiangguo Wang, Yunlong Xiang, Qianhua Xu
Publikováno v:
Science Advances
Description
Evolutionary analyses reveal conservation and divergence of epigenetic transition during early development across mammals.
While mouse remains the most popular model, the conservation of parental-to-embryonic epigenetic transiti
Evolutionary analyses reveal conservation and divergence of epigenetic transition during early development across mammals.
While mouse remains the most popular model, the conservation of parental-to-embryonic epigenetic transiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de31b45f434c4ef1f0820f2a96289f2
http://europepmc.org/articles/PMC8612685
http://europepmc.org/articles/PMC8612685
Autor:
Weikun Xia, Wei Xie, Weimin Shen, Qiuyan Wang, Xiaotong Wu, Ryohei Nakamura, Anming Meng, Lijia Li, Bofeng Liu, Hiroyuki Takeda, Hongmei Zhang, Yu Zhang, Feng Liu, Xi Wu, Bingjie Zhang
Publikováno v:
Science Advances
Description
Enhancer dememorization resets developmental clock and may unify epigenetic reprogramming modes in mammals and nonmammals.
Marked epigenetic reprogramming is essential to convert terminally differentiated gametes to totipotent e
Enhancer dememorization resets developmental clock and may unify epigenetic reprogramming modes in mammals and nonmammals.
Marked epigenetic reprogramming is essential to convert terminally differentiated gametes to totipotent e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e6e0688054cd18a6936551a93513b1
https://doi.org/10.1101/2021.10.10.463758
https://doi.org/10.1101/2021.10.10.463758
Autor:
Guang Yu, Senlin Shi, Yile Zhang, Haixia Jin, Kai Xu, Jiawei Xu, Tong Li, Wenyan Song, Yang Wang, Wei Xie, Zili Lin, Bofeng Liu, Lijia Li, Nan Zhang, Jie Na, Dayuan Shi, Guidong Yao, Yingpu Sun, Xueshan Ma, Zhiqin Bu, Weikun Xia, Qiujun Wang, Linli Hu, Xia Chen
Publikováno v:
Science. 365:353-360
Epigenetics of human embryonic development Substantial epigenetic reprogramming occurs in mammalian early development. Xia et al. investigated the reprogramming dynamics of three key histone modifications in human early embryonic development. The rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7234462f44e2ea1d8447ce90f34cb6
https://doi.org/10.1126/science.aaw5118
https://doi.org/10.1126/science.aaw5118
Publikováno v:
APL Bioengineering, Vol 8, Iss 1, Pp 016121-016121-11 (2024)
Ascertaining the collective viability of cells in different cell culture conditions has typically relied on averaging colorimetric indicators and is often reported out in simple binary readouts. Recent research has combined viability assessment techn
Externí odkaz:
https://doaj.org/article/0e44c2e125cf475d8494a1007eba1e50
Autor:
Chunyi Huang, Zili Lin, Qianhua Xu, Fangyuan Zheng, Feng Kong, Jingyi Wu, Weikun Xia, Kai Xu, Yunlong Xiang, Junwei Nie, Guang Yu, Qiujun Wang, Cui Qiu, Jie Na, Bofeng Liu, Yang Yu, Lijia Li, Zhuqing Xiong, Ling Liu, Peizhe Wang, Wei Xie, Su Feng, Fangnong Lai
Publikováno v:
Nature. 587(7832)
Zygotic genome activation (ZGA) is the first transcription event in life1. However, it is unclear how RNA polymerase is engaged in initiating ZGA in mammals. Here, by developing small-scale Tn5-assisted chromatin cleavage with sequencing (Stacc–seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4a16a3a338ffedcf685c8db100e027
https://pubmed.ncbi.nlm.nih.gov/33116310
https://pubmed.ncbi.nlm.nih.gov/33116310
Autor:
Yu Zhang, Weikun Xia, Chunyi Huang, Yuanyuan Li, Bing Zhu, Wen-Hao Zhang, Xiguang Xu, Hehuang Xie, Wei Xie, Guang Yu, Qiujun Wang, Xuan Ming
Publikováno v:
Nature genetics. 52(8)
The epigenome, including DNA methylation, is stably propagated during mitotic division. However, single-cell clonal expansion produces heterogeneous methylomes, thus raising the question of how the DNA methylome remains stable despite constant epigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade6152ec96dec70cb99f2359a61926d
https://pubmed.ncbi.nlm.nih.gov/32690947
https://pubmed.ncbi.nlm.nih.gov/32690947
Autor:
Guang Yu, Robert J. Klose, Zhenhai Du, Bo Huang, Dan-Ya Wu, Qiujun Wang, Weikun Xia, Qiao-Ran Sun, Xin Liu, Wen-Jing Xiong, Yi-Liang Miao, Wei Xie, Li-Yan Wang, Lijia Li, Kai Xu, Hui Zheng, Ke Zhang, Zili Lin, James D.P. Rhodes, Yao Wang, Kim Nasmyth, Yao Yao
Publikováno v:
Molecular Cell. 79:234-250.e9
Somatic cell nuclear transfer (SCNT) can reprogram a somatic nucleus to a totipotent state. However, the re-organization of 3D chromatin structure in this process remains poorly understood. Using low-input Hi-C, we revealed that, during SCNT, the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc4a3c3c489ba06e9ea9845f3fa2a98
https://doi.org/10.1016/j.molcel.2020.06.001
https://doi.org/10.1016/j.molcel.2020.06.001
Autor:
Wen-Hao Zhang, Miguel Fidalgo, Zhenhai Du, Yuanyuan Li, Yunlong Xiang, Weikun Xia, Yu Zhang, Feng Xu, Wei Xie, Zhen-Ao Zhao, Qiangzong Yin, Lei Li, Xu Peng, Jing Ma, Qiujun Wang, Jianlong Wang
Publikováno v:
Nature genetics. 50(1)
In mammals, all somatic development originates from lineage segregation in early embryos. However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell fate commitment remains poorly characterized. Here we report a compre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117e2070f81587203dbf04f711332850
https://pubmed.ncbi.nlm.nih.gov/29203909
https://pubmed.ncbi.nlm.nih.gov/29203909
Autor:
Kaili Liu, Qiujun Wang, Chen Zhou, Chia-An Yen, Weikun Xia, Jing Zhang, Yong-hui Jiang, Wen-Hao Zhang, Jiayu Chen, Rui Gao, Yu Zhang, Wei Xie, Shaorong Gao, Danny Leung, Zai Chang, Ah Young Lee, Aaron J. Towers, Tian-Peng Gu, Xiuqi Chen, Yuanyuan Li
Publikováno v:
Molecular cell. 64(6)
The methylcytosine oxidase TET proteins play important roles in DNA demethylation and development. However, it remains elusive how exactly they target substrates and execute oxidation. Interestingly, we found that, in mice, the full-length TET1 isofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564e9d5b4d244dc4886bed5af6d7ce43
https://pubmed.ncbi.nlm.nih.gov/27916660
https://pubmed.ncbi.nlm.nih.gov/27916660