Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Weike Liao"'
Autor:
Tingting Wu, Hu Cheng, Lijie Sima, Zhongyuan Wang, Weiwei Ouyang, Jianta Wang, Yunlei Hou, Dongsheng Zhao, Weike Liao, Chujiao Hu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
The PD-1/PD-L1 pathway is considered as one of the most promising immune checkpoints in tumour immunotherapy. However, researchers are faced with the inherent limitations of antibodies, driving them to pursue PD-L1 small molecule inhibitors. Virtual
Externí odkaz:
https://doaj.org/article/ceebcdd984b74909bc1853baa6d983a2
Autor:
Lijie Sima, Zhongyuan Wang, Ling Yu, Youli Hou, Dongsheng Zhao, Bilan Luo, Weike Liao, Xinfu Liu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
ABSTRCTDysregulated HGF/c-Met pathway has been implicated in multiple human cancers and has become an attractive target for cancer intervention. Herein, we report the discovery of N-(3-fluoro-4-((2-(3-hydroxyazetidine-1-carboxamido)pyridin-4-yl)oxy)p
Externí odkaz:
https://doaj.org/article/96fe292df9ad44eea2df8314111af94d
Autor:
Rui Chen, Zhongyuan Wang, Lijie Sima, Hu Cheng, Bilan Luo, Jianta Wang, Bing Guo, Shunyi Mao, Zhixu Zhou, Jingang Peng, Lei Tang, Xinfu Liu, Weike Liao
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Inhibition of PI3K pathway has become a desirable strategy for cancer treatment. In this work, a series of 2, 6, 8-substituted Imidazo[1,2-a]pyridine derivatives were designed and screened for their activities against PI3Kα and a panel of PI3Kα-add
Externí odkaz:
https://doaj.org/article/6e1797e3188e4735aad8d0d57f0377db
Publikováno v:
Journal of Heterocyclic Chemistry. 59:137-143
Autor:
Qian Guo, Huifang Chai, Tianhui Liao, Weike Liao, Zhixu Zhou, Wenjun Ye, Qingmei Wu, Chunshen Zhao
In current work, we have firstly synthesized 4-(2-chlorobenzyl)-1-(4-hydroxy-3- ((4-hydroxypiperidin-1-yl)methyl)-5-methoxyphenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one (1) by ring-opening, cyclization, substitution, doamine condensation and Man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b31bbe51e8234d69c7e16a2e3081e8
https://doi.org/10.22541/au.161373272.20219104/v1
https://doi.org/10.22541/au.161373272.20219104/v1
Publikováno v:
Journal of Molecular Structure. 1253:132311
Autor:
Yumei Chen, Wenjun Ye, Dongmei Chen, Zhixu Zhou, Chunshen Zhao, Zhong-Yuan Wang, Tianhui Liao, Weike Liao
Publikováno v:
Journal of Molecular Structure. 1250:131796
The N-(3-((1-(5-bromo-2-(pyrrolidin-1-yl)phenyl)-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin- 4(5H)-yl)methyl)phenyl)-2-thiomorpholinoacetamide is a novel compound having the [ 1 , 2 , 4 ]triazolo[4,3-a]quinazolinone. It was synthesized by nine steps and
Autor:
Juan Xie, Qiancheng Lei, Lei Tang, Weike Liao, Yinliang Qi, Yufei Han, Ye Tian, Guowei Gong, Jiaan Liu, Ming Sun, Yanfang Zhao, Zhongyuan Wang, Rui Chen
Publikováno v:
European journal of medicinal chemistry. 197
Using a rational design strategy for isoform-selective inhibition of PI3Kα, two series of novel 2,3,4,5-tetra-substituted thiophene derivatives containing either diaryl urea or N-Acylarylhydrazone scaffold were designed and synthesized. The most pro
Autor:
Zhaopeng Zheng, Zhixu Zhou, Wenjun Ye, D. Z. Yang, Qingmei Wu, Qian Guo, Chunshen Zhao, Huifang Chai, Weike Liao, Tianhui Liao
Publikováno v:
Journal of Molecular Structure. 1247:131367
In current work, we have firstly synthesized 4-(2-chlorobenzyl)-1-(4‑hydroxy-3- ((4-hydroxypiperidin-1-yl)methyl)-5-methoxyphenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one (1). The structural properties of 1 were explored using spectroscopy (1H N
Publikováno v:
Journal of Molecular Structure. 1245:131101
Derivatives of imidazo[1,2-a]pyridine, a type of fused heterocyclic substance, play major roles in the chemical fields and are confirmed to be the core fragments of various drug molecules. In this study, the title compound was designed and synthesize