Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Weikang Ma"'
Autor:
Jiranun Jiratrakanvong, Jinjian Shao, Jiaqi Li, Miguel Menendez Alvarez, Xintian Li, Prajwal Das, Grant Nikseresht, Nikhil Miskin, Ran Huo, Jules Nabon, Tristan Leduc, Eric Zhang, Weikang Ma, Gady Agam, Thomas C. Irving
Publikováno v:
Journal of Synchrotron Radiation, Vol 31, Iss 5, Pp 1401-1408 (2024)
MuscleX is an integrated, open-source computer software suite for data reduction of X-ray fiber diffraction patterns from striated muscle and other fibrous systems. It is written in Python and runs on Linux, Microsoft Windows or macOS. Most modules c
Externí odkaz:
https://doaj.org/article/6394f97a58f94baeabb89283c33f5ba7
Autor:
Anthony L. Hessel, Michel N. Kuehn, Seong-Won Han, Weikang Ma, Thomas C. Irving, Brent A. Momb, Taejeong Song, Sakthivel Sadayappan, Wolfgang A. Linke, Bradley M. Palmer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract In striated muscle, the sarcomeric protein myosin-binding protein-C (MyBP-C) is bound to the myosin thick filament and is predicted to stabilize myosin heads in a docked position against the thick filament, which limits crossbridge formation
Externí odkaz:
https://doaj.org/article/10a433d29a114c5bb280881b6bad3e35
Autor:
Anthony L. Hessel, Nichlas M. Engels, Michel N. Kuehn, Devin Nissen, Rachel L. Sadler, Weikang Ma, Thomas C. Irving, Wolfgang A. Linke, Samantha P. Harris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Muscle contraction is produced via the interaction of myofilaments and is regulated so that muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and flexible protein that is tightly bound to the thick filament at it
Externí odkaz:
https://doaj.org/article/3e3b21ca5df3481fb34d9c953325e1ab
Autor:
Michelle Rodriguez Garcia, Jeffrey Schmeckpeper, Maicon Landim-Vieira, Isabella Leite Coscarella, Xuan Fang, Weikang Ma, Payton A. Spran, Shengyao Yuan, Lin Qi, Aida Rahimi Kahmini, M. Benjamin Shoemaker, James B. Atkinson, Peter M. Kekenes-Huskey, Thomas C. Irving, Prescott Bryant Chase, Björn C. Knollmann, Jose Renato Pinto
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14572 (2023)
The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of unknown significance (p.A868T) on cardiac muscle structure and functi
Externí odkaz:
https://doaj.org/article/5f43ec315b34474db0d9718fcffd7e19
Autor:
Johan Lindqvist, Weikang Ma, Frank Li, Yaeren Hernandez, Justin Kolb, Balazs Kiss, Paola Tonino, Robbert van der Pijl, Esmat Karimi, Henry Gong, Josh Strom, Zaynab Hourani, John E. Smith, Coen Ottenheijm, Thomas Irving, Henk Granzier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nebulin-based nemaline myopathy is a heterogenous disease with unclear pathological mechanisms. Here, the authors generate a mouse model that mimics the most common genetic cause of the disease and demonstrate that muscle weakness in this model is as
Externí odkaz:
https://doaj.org/article/fb151f3beab74614afcba240bd5ebe48
Autor:
Peter O. Awinda, Weikang Ma, Kyrah L. Turner, Jing Zhao, Henry Gong, Mindy S. Thompson, Kenneth S. Campbell, Thomas C. Irving, Bertrand C. W. Tanner
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15084 (2022)
Myosin cross-bridges dissociate from actin following Mg2+-adenosine triphosphate (MgATP) binding. Myosin hydrolyses MgATP into inorganic phosphate (Pi) and Mg2+-adenosine diphosphate (ADP), and release of these hydrolysis products drives chemo-mechan
Externí odkaz:
https://doaj.org/article/4b3d2da720e0436f80c18278c270a1ce
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14517 (2022)
Sufficient cardiac contractility is necessary to ensure the sufficient cardiac output to provide an adequate end-organ perfusion. Inadequate cardiac output and the diminished perfusion of vital organs from depressed myocardium contractility is a hall
Externí odkaz:
https://doaj.org/article/e83aa3477baf485ead7f67f2b92ee1e0
Autor:
Weikang Ma, Thomas C. Irving
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3052 (2022)
Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level structural information from striated muscle fibers under hydrated physiological conditions. For many decades this technique had been used primarily for investig
Externí odkaz:
https://doaj.org/article/eb6928c4545d4fd0851574416c3bafb1
Autor:
Venus Joumaa, Ian C. Smith, Atsuki Fukutani, Timothy R. Leonard, Weikang Ma, Srboljub M. Mijailovich, Thomas C. Irving, Walter Herzog
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8526 (2021)
Our purpose was to use small-angle X-ray diffraction to investigate the structural changes within sarcomeres at steady-state isometric contraction following active lengthening and shortening, compared to purely isometric contractions performed at the
Externí odkaz:
https://doaj.org/article/29caed81e6854229a9a4f87ee17ca84f
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5504 (2020)
The flight muscle of Manduca sexta (DLM1) is an emerging model system for biophysical studies of muscle contraction. Unlike the well-studied indirect flight muscle of Lethocerus and Drosophila, the DLM1 of Manduca is a synchronous muscle, as are the
Externí odkaz:
https://doaj.org/article/7247f13e2a7c44ddbd5fddcf286cf054