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Akademický článek

Static magnetic field-modulated mesenchymal stem cell-derived mitochondria-containing microvesicles for enhanced intervertebral disc degeneration therapy

Autor: Pengzhi Shi, Haiyang Gao, Zhangrong Cheng, Kangcheng Zhao, Yuhang Chen, Xianglong Chen, Weikang Gan, Anran Zhang, Cao Yang, Yukun Zhang

Publikováno v: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-22 (2024)

Abstract Intervertebral disc degeneration (IVDD) is characterized by the senescence and declining vitality of nucleus pulposus cells (NPCs), often driven by mitochondrial dysfunction. This study elucidates that mesenchymal stem cells (MSCs) play a cr

Externí odkaz: https://doaj.org/article/b738524f2b0a4cea84fac07af762a16a

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Akademický článek

Plant molecules reinforce bone repair: Novel insights into phenol-modified bone tissue engineering scaffolds for the treatment of bone defects

Autor: Yuhang Chen, Weikang Gan, Zhangrong Cheng, Anran Zhang, Pengzhi Shi, Yukun Zhang

Publikováno v: Materials Today Bio, Vol 24, Iss , Pp 100920- (2024)

Bone defects have become a major cause of disability and death. To overcome the limitations of natural bone implants, including donor shortages and immune rejection risks, bone tissue engineering (BTE) scaffolds have emerged as a promising therapy fo

Externí odkaz: https://doaj.org/article/fd4c43a2e36e45609ecbf4bf32f01f68

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Akademický článek

Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics

Autor: Pengzhi Shi, Zhangrong Cheng, Kangcheng Zhao, Yuhang Chen, Anran Zhang, Weikang Gan, Yukun Zhang

Publikováno v: Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-27 (2023)

Abstract Osteosarcoma, the most common malignant tumor of the bone, seriously influences people’s lives and increases their economic burden. Conventional chemotherapy drugs achieve limited therapeutic effects owing to poor targeting and severe syst

Externí odkaz: https://doaj.org/article/f8fb467c458f42d6a216facc8bbebf08

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Akademický článek

Therapeutic perspectives of exosomes in glucocorticoid-induced osteoarthrosis

Autor: Bin Lv, Zhangrong Cheng, Yajie Yu, Yuhang Chen, Weikang Gan, Shuai Li, Kangcheng Zhao, Cao Yang, Yukun Zhang

Publikováno v: Frontiers in Surgery, Vol 9 (2022)

Exosomes are widely involved in a variety of physiological and pathological processes. These important roles are also hidden in the physiological processes related to bone. Chondrocytes, osteoblasts, synovial fibroblasts, and bone marrow mesenchymal

Externí odkaz: https://doaj.org/article/4f79dd4803c243899c2ec29be731e275

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Akademický článek

Current Insights Into the Maintenance of Structure and Function of Intervertebral Disc: A Review of the Regulatory Role of Growth and Differentiation Factor-5

Autor: Bin Lv, Weikang Gan, Zhangrong Cheng, Juntao Wu, Yuhang Chen, Kangchen Zhao, Yukun Zhang

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Intervertebral disc degeneration (IDD), characterized by conversion of genotypic and phenotypic, is a major etiology of low back pain and disability. In general, this process starts with alteration of metabolic homeostasis leading to ongoing inflamma

Externí odkaz: https://doaj.org/article/153d6be5616d42faa27346bf30eea023

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