Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Weijuan, Shao"'
Autor:
Juan Pang, Fitore Raka, Alya Abbas Heirali, Weijuan Shao, Dinghui Liu, Jianqiu Gu, Jia Nuo Feng, Chieko Mineo, Philip W. Shaul, Xiaoxian Qian, Bryan Coburn, Khosrow Adeli, Wenhua Ling, Tianru Jin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I) i
Externí odkaz:
https://doaj.org/article/7768586838704f1f9466b8b884b7e232
Publikováno v:
Physiological Reports, Vol 11, Iss 5, Pp n/a-n/a (2023)
Abstract Metabolic functions of GLP‐1 and its analogues have been extensively investigated. In addition to acting as an incretin and reducing body weight, we and others have suggested the existence of GLP‐1/fibroblast growth factor 21 (FGF21) axi
Externí odkaz:
https://doaj.org/article/e5f075302aaf4baab111b0a93f831b10
Autor:
Weijuan Shao, Tianru Jin
Publikováno v:
Chronic Diseases and Translational Medicine, Vol 8, Iss 1, Pp 19-25 (2022)
Abstract Fibroblast growth factor 21 (FGF21) is a fasting or stress inducible metabolic hormone produced mainly in the liver. It plays important roles in regulating both glucose and lipid homeostasis via interacting with a heterodimeric receptor comp
Externí odkaz:
https://doaj.org/article/27e3ef2d2bfa4ae4bb0e6fbc8665bac5
Publikováno v:
Journal of Molecular Endocrinology. 69:343-356
Although canonical Wnt signaling pathway activation was shown to negatively regulate adipogenesis, recent investigations suggest that Wnt pathway effectors TCF7L2 and β-catenin (β-cat) in adipose tissues are also involved in energy homeostasis duri
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000444 (2019)
The bipartite transcription factor β-catenin (β-cat)/T cell factor (TCF), formed by free β-cat and a given TCF family member, serves as the effector of the developmental Wnt signaling cascade. β-cat/TCFs also serve as effectors of certain peptide
Externí odkaz:
https://doaj.org/article/c18390cae6344ec7a9d26db1fb0bcdce
Publikováno v:
Physiological Reports. 11
Autor:
Dinghui Liu, Juan Pang, Yong Zeng, Weijuan Shao, Tianru Jin, Housheng Hansen He, Wenhua Ling, Jianqiu Gu, Xiaoxian Qian
Publikováno v:
Hepatology. 74:2154-2169
BACKGROUND AND AIMS Several studies have shown that expression of hepatic fibroblast growth factor 21 (FGF21) can be stimulated by glucagon-like peptide 1 (GLP-1)-based diabetes drugs. As GLP-1 receptor (GLP-1R) is unlikely to be expressed in hepatoc
Autor:
Jim Hu, Juan Pang, Jianqiu Gu, Tianru Jin, Lili Tian, Dinghui Liu, Yasaman Badakhshi, Weijuan Shao
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 321:E292-E304
We have generated the transgenic mouse line LTCFDN in which dominant negative TCF7L2 (TCF7L2DN) is specifically expressed in the liver during adulthood. Male but not female LTCFDN mice showed elevated hepatic and plasma triglyceride (TG) levels, indi
Autor:
Weijuan Shao, Xiaoquan Xiong, Wilfred Ip, Fenghao Xu, Zhuolun Song, Kejing Zeng, Marcela Hernandez, Tao Liang, Jianping Weng, Herbert Gaisano, M. Cristina Nostro, Tianru Jin
Publikováno v:
Molecular Metabolism, Vol 4, Iss 4, Pp 344-352 (2015)
Objective: Disruption of TCF7L2 in mouse pancreatic β-cells has generated different outcomes in several investigations. Here we aim to clarify role of β-cell TCF7L2 and Wnt signaling using a functional-knockdown approach. Methods: Adenovirus-mediat
Externí odkaz:
https://doaj.org/article/19e9633a81d047389bb4fe08435103cb
Autor:
Juan Pang, Fitore Raka, Alya Abbas Heirali, Weijuan Shao, Dinghui Liu, Jianqiu Gu, Jia Nuo Feng, Chieko Mineo, Philip Shaul, Xiaoxian Qian, Bryan Coburn, Khosrow Adeli, Wenhua Ling, Tianru Jin
Two common features of dietary polyphenols have hampered our mechanistic understanding of their metabolic beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7117160334d8424261c27a03f7d37ac0
https://doi.org/10.21203/rs.3.rs-2050101/v1
https://doi.org/10.21203/rs.3.rs-2050101/v1