Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Weijin Sheng"'
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 1243-1256 (2022)
The present study aimed to evaluate the anti-tumor efficacy of the epidermal growth factor receptor (EGFR)-targeting recombinant fusion protein Fv-LDP-D3 and its antibody-drug conjugate Fv-LDP-D3-AE against esophageal cancer. Fv-LDP-D3, consisting of
Externí odkaz:
https://doaj.org/article/97c8b2f091ba4c18afabd578bf2af9e7
Autor:
Jianhua Gong, Yanbo Zheng, Ying Wang, Weijin Sheng, Yi Li, Xiujun Liu, Shuyi Si, Rongguang Shao, Yongsu Zhen
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191984 (2018)
Through cell-based screening models, we have identified a new compound IMB5043, a thiophenylated pyridazinone, which exerted cytotoxicity against cancer cells. In the present study, we evaluated its antitumor efficacy and the possible mechanism. By M
Externí odkaz:
https://doaj.org/article/36710e6d2df94d3198bc0047d29d345d
Publikováno v:
Journal of Cancer Research & Therapeutics; Dec2023, Vol. 19 Issue 6, p1603-1609, 7p
Publikováno v:
International journal of biological macromolecules. 187
Human serum albumin (HSA)-based therapeutics have attracted tremendous attention in the development of anticancer agents. The versatile properties of HSA make HSA-based therapeutics possess improved pharmacokinetics, extended circulation half-life, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6aa85c5506a4b52bf95a18f0a17351
https://pubmed.ncbi.nlm.nih.gov/34284054
https://pubmed.ncbi.nlm.nih.gov/34284054
Publikováno v:
Oncology Reports
Efficient enrichment and transmembrane transport of cytotoxic reagents are considered to be effective strategies to increase the efficiency and selectivity of antitumor drugs targeting solid tumors. In the present study, a recombinant protein ABD‑L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133a5029750d6fa55c0b3c7629539c7e
https://pubmed.ncbi.nlm.nih.gov/32020213
https://pubmed.ncbi.nlm.nih.gov/32020213
Publikováno v:
Cancer Cell International
Cancer Cell International, Vol 19, Iss 1, Pp 1-13 (2019)
Cancer Cell International, Vol 19, Iss 1, Pp 1-13 (2019)
Background Pancreatic cancer stem cells (CSCs), a special population of cells, renew themselves infinitely and resist to various treatment. Gramicidin A (GrA), an ionophore antibiotic derived from microorganism, can form channels across the cell memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605f8586531625603d6996dcfd17538d
https://doi.org/10.1186/s12935-019-0862-6
https://doi.org/10.1186/s12935-019-0862-6
Autor:
Rui-Qi Wang, Cong Li, Zhuorong Li, Lei Zhang, Yuhong Wang, Min Jiang, Weijin Sheng, Jing Geng
Publikováno v:
Phytomedicine : international journal of phytotherapy and phytopharmacology. 66
Natural killer (NK) cells play important roles in immune responses and have been wildly used in immunotherapy. Nevertheless, some limitations remain. It is urgent to explore novel and safe strategies to enhance NK cell activity.The aim of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e191124b0182252f238eec62cb9249
https://pubmed.ncbi.nlm.nih.gov/31790901
https://pubmed.ncbi.nlm.nih.gov/31790901
Autor:
Shenghua Zhang, Yi Li, Wang Yangyang, Shu-zhen Chen, Xiujun Liu, Liang Li, Yong-Su Zhen, Xiaofei Wang, Weijin Sheng
Publikováno v:
Molecular pharmaceutics. 15(6)
Enhanced macropinocytosis has been found in K-Ras mutant pancreatic cancer cells, through which albumin can massively enter into the K-Ras-driven cancer cells, suggesting its role in serving as a macropinocytosis-intensifying drug delivery carrier. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cf472e23283b4c8ce3eca3f682ad06
https://pubmed.ncbi.nlm.nih.gov/29757658
https://pubmed.ncbi.nlm.nih.gov/29757658
Autor:
Ying Wang, Yong-Su Zhen, Yan-Bo Zheng, Rong-Guang Shao, Weijin Sheng, Yi Li, Xiujun Liu, Shuyi Si, Jian-Hua Gong
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191984 (2018)
PLoS ONE
PLoS ONE
Through cell-based screening models, we have identified a new compound IMB5043, a thiophenylated pyridazinone, which exerted cytotoxicity against cancer cells. In the present study, we evaluated its antitumor efficacy and the possible mechanism. By M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f100c36fce1db1ecafe21106680d6f4a
http://europepmc.org/articles/PMC5796703?pdf=render
http://europepmc.org/articles/PMC5796703?pdf=render
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 117:105-116
Gelatinases play important roles in tumour invasion and metastasis and are thus considered promising targets for cancer therapy. In this study, a new single-chain variable fragment (scFv)-based fusion protein Fv-LDP, composed of the anti-gelatinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e249ab171690e9569a995dc0f1c89b74
https://doi.org/10.1111/bcpt.12379
https://doi.org/10.1111/bcpt.12379