Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Weijie Qin"'
Autor:
Pengyun Li, Xiaotong Hu, Zhiya Fan, Shiyang Sun, Qijie Ran, Ting Wei, Pengli Wei, Qiyu Jiang, Jian Yan, Ning Yang, Changkai Jia, Tingting Yang, Yaqiu Mao, Xu Cai, Tingting Xu, Zhiyuan Zhao, Xiaohong Qian, Weijie Qin, Xiaomei Zhuang, Feng Fan, Junhai Xiao, Zhibing Zheng, Song Li
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-30 (2024)
Abstract Background Targeted protein degradation of neosubstrates plays a crucial role in hematological cancer treatment involving immunomodulatory imide drugs (IMiDs) therapy. Nevertheless, the persistence of inevitable drug resistance and hematolog
Externí odkaz:
https://doaj.org/article/53485170677d439b9bf56471960e9a2e
Autor:
Qiang Zhu, Didi Geng, Jingchao Li, Jinqiu Zhang, Haofan Sun, Zhiya Fan, Jiahui He, Ninghui Hao, Yinping Tian, Liuqing Wen, Tiehai Li, Weijie Qin, Xiakun Chu, Yong Wang, Wen Yi
Publikováno v:
Advanced Science, Vol 11, Iss 24, Pp n/a-n/a (2024)
Abstract Glycans are complex biomolecules that encode rich information and regulate various biological processes, such as fertilization, host‐pathogen binding, and immune recognition, through interactions with glycan‐binding proteins. A key drivi
Externí odkaz:
https://doaj.org/article/1cd2e9ea3ad14da797c67e0ae9b89a8a
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The key role of RNA-binding proteins (RBPs) in posttranscriptional regulation of gene expression is intimately tied to their subcellular localization. Here, we show a subcellular-specific RNA labeling method for efficient enrichment and deep
Externí odkaz:
https://doaj.org/article/f10b6e247fdb4672a24e7c998a01355a
Autor:
Zhuokun Du, Qianying Yang, Yuanyuan Liu, Sijie Chen, Hongxian Zhao, Haihong Bai, Wei Shao, Yangjun Zhang, Weijie Qin
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
N-glycosylation and phosphorylation, two common posttranslational modifications, play important roles in various biological processes and are extensively studied for biomarker and drug target screening. Because of their low abundance, enrichment of N
Externí odkaz:
https://doaj.org/article/73711542b69f40b7827b74d8adbc8d40
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
N-Glycosylation is one of the most common and important post-translational modification methods, and it plays a vital role in controlling many biological processes. Increasing discovery of abnormal alterations in N-linked glycans associated with many
Externí odkaz:
https://doaj.org/article/1077790fd2ab4a66bf7b7c549938d8cf
An angled-shape tip-based strategy for highly sensitive proteomic profiling of a low number of cells
Publikováno v:
Analytical Methods. 15:1215-1222
An angled-shape tip-based strategy for highly sensitive proteomic profiling of a low number of cells.
Publikováno v:
Analytical Chemistry. 94:14956-14964
Blood is one of the most important clinical samples for protein biomarker discovery, as it provides rich physiological and pathological information and is easy to obtain with low invasiveness. However, the discovery of protein biomarkers in the blood
Autor:
Qiang Zhu, Hong Zhou, Liming Wu, Zhenyuan Lai, Didi Geng, Weiwei Yang, Jie Zhang, Zhiya Fan, Weijie Qin, Yong Wang, Ruhong Zhou, Wen Yi
Publikováno v:
Nature Chemical Biology. 18:1087-1095
Publikováno v:
RSC Advances. 12:33409-33418
Extracellular vesicles (EVs) are membranous vesicles released by cells that carry a number of biologically important components such as lipids, proteins, and mRNAs. EVs can mediate cancer cell migration, invasion, angiogenesis, and cell survival, gre
Publikováno v:
Chinese Journal of Chromatography. 39:1182-1190
O-linked β-N-acetylglucosamine (O-GlcNAc), an important post-translational modification of proteins, plays an essential role in maintaining normal biological activities of organisms. Studies have shown that the disruption of O-GlcNAc homeostasis is