Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Weihsu Claire Chen"'
Autor:
Andy G. X. Zeng, Suraj Bansal, Liqing Jin, Amanda Mitchell, Weihsu Claire Chen, Hussein A. Abbas, Michelle Chan-Seng-Yue, Veronique Voisin, Peter van Galen, Anne Tierens, Meyling Cheok, Claude Preudhomme, Hervé Dombret, Naval Daver, P. Andrew Futreal, Mark D. Minden, James A. Kennedy, Jean C. Y. Wang, John E. Dick
Publikováno v:
Nature Medicine. 28:1212-1223
The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising therapies entering clinical translation, yet patient responses remain heterogeneous, and biomarkers for tailoring treatment are lacking. To understand how disease het
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d9637cf0aa188862b6f4599d53fd65
https://doi.org/10.1038/s41591-022-01819-x
https://doi.org/10.1038/s41591-022-01819-x
Autor:
Andy G.X. Zeng, Suraj Bansal, Liqing Jin, Amanda Mitchell, Weihsu Claire Chen, Hussein A. Abbas, Michelle Chan-Seng-Yue, Veronique Voisin, Peter van Galen, Anne Tierens, Meyling Cheok, Claude Preudhomme, Hervé Dombret, Naval Daver, P Andrew Futreal, Mark D. Minden, James A. Kennedy, Jean C.Y. Wang, John E. Dick
The treatment landscape of AML is evolving with promising therapies entering clinical translation, yet patient responses remain heterogeneous and biomarkers for tailoring treatment are lacking. To understand how disease heterogeneity links with thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c695c8a579d0f3118bcc0dc73ba33c74
https://doi.org/10.1101/2022.01.25.476266
https://doi.org/10.1101/2022.01.25.476266
Publikováno v:
Pharmaceutical Research. 33:1104-1114
This study was aimed at developing a new active loading method to stably encapsulate staurosporine (STS), a water insoluble drug, into lipid-based nanoparticles (LNPs) for drug targeting to tumors. A limited amount of DMSO was included during the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318d31b74f6deec2d568630e68229abc
https://doi.org/10.1007/s11095-015-1854-4
https://doi.org/10.1007/s11095-015-1854-4
Publikováno v:
Molecular pharmaceutics. 14(6)
Mefloquine (Mef), a poorly soluble and highly bitter drug, has been used for malaria prophylaxis and treatment. The dosage form for Mef is mostly available as adult tablets, and thus children under the age of 5 suffer from poor medication adherence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af426294075eb2693798517b3b113e4
https://pubmed.ncbi.nlm.nih.gov/28460165
https://pubmed.ncbi.nlm.nih.gov/28460165
Autor:
Liran I. Shlush, Sasan Zandi, Amanda Mitchell, Weihsu Claire Chen, Joseph M. Brandwein, Vikas Gupta, James A. Kennedy, Aaron D. Schimmer, Andre C. Schuh, Karen W. Yee, Jessica L. McLeod, Monica Doedens, Jessie J. F. Medeiros, Rene Marke, Hyeoung Joon Kim, Kwon Lee, John D. McPherson, Thomas J. Hudson, The HALT Pan-Leukemia Gene Panel Consortium, Andrew M. K. Brown, Fouad Yousif, Quang M. Trinh, Lincoln D. Stein, Mark D. Minden, Jean C. Y. Wang, John E. Dick
Publikováno v:
Nature, vol 506, iss 7488
Nature, 506, 7488, pp. 328-33
Nature, 506, 328-33
Nature
Nature, 506, 7488, pp. 328-33
Nature, 506, 328-33
Nature
Item does not contain fulltext In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly understood, as AML is typically diagnosed without observati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b531b1ad02f71dd4a3c375a52a7f5c89
https://doi.org/10.1038/nature13038
https://doi.org/10.1038/nature13038
Publikováno v:
Nanotechnology Reviews, Vol 2, Iss 2, Pp 201-213 (2013)
Nanoparticle-based drug delivery is an emerging technology for targeting therapeutics to the diseased site for enhanced therapy and reduced toxicity. A number of pharmaceutical products that involve nanotechnology have been approved for clinical use,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fb18556078936229a079849975e6dc
https://doaj.org/article/a46acc9b887c4d54a41cf4c1ce76df1a
https://doaj.org/article/a46acc9b887c4d54a41cf4c1ce76df1a
Publikováno v:
ejnm. 4:89-93
The active targeting approach has been widely employed to improve nanoparticle drug delivery. Contrary to popular conceptions, attachment of a targeting ligand to a nanopaticle does not alter its biodistribution, but only increases its internalizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bc0590b590a6ca007476485d9749e36
https://doi.org/10.1515/ejnm-2012-0010
https://doi.org/10.1515/ejnm-2012-0010
Autor:
Mark D. Minden, Liqing Jin, Weihsu Claire Chen, Ken I. Mills, Tino Schenk, Louise Howell, Martin Dugas, Carsten Müller-Tidow, Stefanie Göllner, Katja Hebestreit, Hans-Ulrich Klein, Kevin Petrie, Laurence J. Marton, Jean C.Y. Wang, Patrick M. Woster, Alan Kenneth Burnett, John E. Dick, Andreea C. Popescu, Robert A. Casero, Arthur Zelent
Publikováno v:
Nature Medicine. 18:605-611
Acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML), characterized by the t(15;17)-associated PML-RARA fusion, has been successfully treated with therapy utilizing all-trans-retinoic acid (ATRA) to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12a297e6764e54039df2f38cf988ce3
https://doi.org/10.1038/nm.2661
https://doi.org/10.1038/nm.2661
Autor:
Amy Saur Conway, Alex Kentsis, Ilene Galinsky, Casie Reed, B. Klebanov, Jean C.Y. Wang, Weihsu Claire Chen, Anthony Letai, M. Kauffman, Alla Berezovskaya, Yosef Landesman, Scott J. Rodig, Julia Etchin, A T Look, Amanda L. Christie, C E L Ng, Bonnie Thi Le, Joan Montero, Richard Stone, Sophia Adamia, Sharon Shacham, Andrew L. Kung, Marc R. Mansour
Publikováno v:
Leukemia. 30
Currently available combination chemotherapy for acute myeloid leukemia (AML) often fails to result in long-term remissions, emphasizing the need for novel therapeutic strategies. We reasoned that targeted inhibition of a prominent nuclear exporter,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe1536bf6711adb03b95e51b0bee55b
https://doi.org/10.1038/leu.2015.194
https://doi.org/10.1038/leu.2015.194
Autor:
John E. Dick, Sohyeong Kang, Mark D. Minden, Li Zhang, Jong Bok Lee, Elena Streck, Weihsu Claire Chen
Publikováno v:
Blood. 126:1355-1355
Acute myeloid leukemia (AML) is the most common form of adult acute leukemia that is associated with a low long-term survival rate. While chemotherapy achieves remission in more than 70% of the treated AML patients, most relapse due to residual chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::016ba86bba9d1067018dc0f88a8562f0
https://doi.org/10.1182/blood.v126.23.1355.1355
https://doi.org/10.1182/blood.v126.23.1355.1355