Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Weihsu C Chen"'
Autor:
Weihsu C Chen, Norihito Kawasaki, Corwin M Nycholat, Shoufa Han, Julie Pilotte, Paul R Crocker, James C Paulson
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39039 (2012)
Sialoadhesin (Sn, Siglec-1, CD169) is a member of the sialic acid binding Ig-like lectin (siglec) family expressed on macrophages. Its macrophage specific expression makes it an attractive target for delivering antigens to tissue macrophages via Sn-m
Externí odkaz:
https://doaj.org/article/81aadb4aba3c490595b49bc8a138eb85
Autor:
Li Zhang, John E. Dick, Richard W. Childs, Yueyang Li, Cheryl D'Souza, Paulina Achita, Sohyeong Kang, Sandy D. Der, Dalam Ly, Andrea Arruda, Hyeonjeong Kang, Branson Chen, Elena Streck, Weihsu C. Chen, Mark D. Minden, JongBok Lee
Purpose: To explore the potential of ex vivo expanded healthy donor–derived allogeneic CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia patients.Experimental Design: Clinical-grade DNTs from peripheral blood of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503e1fbf49c6766b1af5a39cdcd47167
https://doi.org/10.1158/1078-0432.c.6526158
https://doi.org/10.1158/1078-0432.c.6526158
Autor:
Li Zhang, John E. Dick, Richard W. Childs, Yueyang Li, Cheryl D'Souza, Paulina Achita, Sohyeong Kang, Sandy D. Der, Dalam Ly, Andrea Arruda, Hyeonjeong Kang, Branson Chen, Elena Streck, Weihsu C. Chen, Mark D. Minden, JongBok Lee
Figure S1. Characterization of ex vivo expanded healthy donor (HD) DNTs; Figure S2. Allogeneic DNTs induce dose- and time- dependent cytotoxicity against leukemic cells; Figure S3. Correlation between the susceptibility of AML patient blasts to DNT-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8662a29a64a1e49105fcaaed3b190baa
https://doi.org/10.1158/1078-0432.22465821
https://doi.org/10.1158/1078-0432.22465821
Autor:
Li Zhang, John E. Dick, Richard W. Childs, Yueyang Li, Cheryl D'Souza, Paulina Achita, Sohyeong Kang, Sandy D. Der, Dalam Ly, Andrea Arruda, Hyeonjeong Kang, Branson Chen, Elena Streck, Weihsu C. Chen, Mark D. Minden, JongBok Lee
Table S1. Clinical information of the 46 AML patients who provided AML cells for in vitro or in vivo assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b37ea45871b5796d06b4355ff72f11
https://doi.org/10.1158/1078-0432.22465818.v1
https://doi.org/10.1158/1078-0432.22465818.v1
Autor:
Li Zhang, John E. Dick, Richard W. Childs, Yueyang Li, Cheryl D'Souza, Paulina Achita, Sohyeong Kang, Sandy D. Der, Dalam Ly, Andrea Arruda, Hyeonjeong Kang, Branson Chen, Elena Streck, Weihsu C. Chen, Mark D. Minden, JongBok Lee
Additional information on materials and methods used in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91c5aeab884722f1faa666636c50928
https://doi.org/10.1158/1078-0432.22465815.v1
https://doi.org/10.1158/1078-0432.22465815.v1
Autor:
Jean C.Y. Wang, John E. Dick, Cynthia Guidos, Donna E. Hogge, Mark D. Minden, Yulia Merkulova, Sofie Perdu, Stevan Lauriault, Goce Bogdanoski, James A. Kennedy, Gitte Gerhard, Jessica McLeod, Andreea C. Popescu, Nathan Mbong, Amanda Mitchell, Yan Xing, Julie S. Yuan, Weihsu C. Chen
Many promising new cancer drugs proceed through preclinical testing and early-phase trials only to fail in late-stage clinical testing. Thus, improved models that better predict survival outcomes and enable the development of biomarkers are needed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace6912470dc065ae62d296a0ae6d9ee
https://doi.org/10.1158/0008-5472.c.6507614
https://doi.org/10.1158/0008-5472.c.6507614
Autor:
Jean C.Y. Wang, John E. Dick, Cynthia Guidos, Donna E. Hogge, Mark D. Minden, Yulia Merkulova, Sofie Perdu, Stevan Lauriault, Goce Bogdanoski, James A. Kennedy, Gitte Gerhard, Jessica McLeod, Andreea C. Popescu, Nathan Mbong, Amanda Mitchell, Yan Xing, Julie S. Yuan, Weihsu C. Chen
Supplemental Methods Supplemental Table 1 Supplemental Figures 1-6 1. Pretreatment with cytarabine potentiates the effects of FED in AML xenografts. Supplemental Figure 2. PF cytometry analysis of AML samples. Supplemental Figure 3. Immunophenotypic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0407829e704b03b162569a3c7be4cf1c
https://doi.org/10.1158/0008-5472.22408769.v1
https://doi.org/10.1158/0008-5472.22408769.v1
Autor:
Wadim L Matochko, Constantin Nelep, Weihsu C Chen, Stephanie Grauer, Karyn McFadden, Vicki Wilson, Kirill Oxenoid
Publikováno v:
Antibody Therapeutics
The most robust strategy in antibody discovery is the use of immunized animals and the ability to isolate and immortalize immune B-cells to hybridoma for further interrogation. However, capturing the full repertoire of an immunized animal is labor in
Autor:
John E. Dick, Sandy D. Der, Mark D. Minden, Richard W. Childs, Cheryl A. D'Souza, Yueyang Li, Sohyeong Kang, Branson Chen, Dalam Ly, Hyeonjeong Kang, Andrea Arruda, Jong Bok Lee, Paulina Achita, Li Zhang, Elena Streck, Weihsu C. Chen
Publikováno v:
Clin Cancer Res
Purpose: To explore the potential of ex vivo expanded healthy donor–derived allogeneic CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia patients. Experimental Design: Clinical-grade DNTs from peripheral blood o
Autor:
Weihsu C. Chen, Christopher Murawsky
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
Therapeutic molecules derived from antibodies have become a dominant class of drugs used to treat human disease. Increasingly, therapeutic antibodies are discovered using transgenic animal systems that have been engineered to express human antibodies