Zobrazeno 1 - 10
of 741
pro vyhledávání: '"Weihong Song"'
Publikováno v:
Fundamental Research, Vol 4, Iss 4, Pp 797-805 (2024)
Peri-operative neurocognitive disorders (PNDs) include postoperative delirium (POD) and postoperative cognitive dysfunction (POCD). Children and the elderly are the two populations most vulnerable to the development of POD and POCD, which results in
Externí odkaz:
https://doaj.org/article/68b17c1c66704b3ca4aafebb68a2d3e5
Autor:
Jie Zhang, Yanshuang Jiang, Xiangjun Dong, Zijun Meng, Liangye Ji, Yu Kang, Mingjing Liu, Weihui Zhou, Weihong Song
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Background Alpha-lipoic acid (ALA) has a neuroprotective effect on neurodegenerative diseases. In the clinic, ALA can improve cognitive impairments in patients with Alzheimer’s disease (AD) and other dementias. Animal studies have confirme
Externí odkaz:
https://doaj.org/article/2a49618c85c84926a9ce0b34f7907e8c
Autor:
Yun Zhang, Susan Lin, Jing Yao, Wantong Cai, Huaqiu Chen, Ailikemu Aierken, Zhe Wang, Weihong Song
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101148- (2024)
As a pathological hallmark of type 2 diabetes mellitus (T2DM), islet amyloid is formed by the aggregation of islet amyloid polypeptide (IAPP). Endoplasmic reticulum (ER) stress interacts with IAPP aggregates and has been implicated in the pathogenesi
Externí odkaz:
https://doaj.org/article/8527f4bb162941a4974f9283ef5f1521
Autor:
Yu Shi, Daochao Huang, Cui Song, Ruixue Cao, Zhao Wang, Dan Wang, Li Zhao, Xiaolu Xu, Congyu Lu, Feng Xiong, Haowen Zhao, Shuxiang Li, Quansheng Zhou, Shuyue Luo, Dongjie Hu, Yun Zhang, Cui Wang, Yiping Shen, Weiting Su, Yili Wu, Karl Schmitz, Shuo Wei, Weihong Song
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Diphthamide is a modified histidine residue unique for eukaryotic translation elongation factor 2 (eEF2), a key ribosomal protein. Loss of this evolutionarily conserved modification causes developmental defects through unknown mechanisms. In
Externí odkaz:
https://doaj.org/article/73982cce84ef49d5907a2ca0149d1f05
Autor:
Qing Zhang, Mengen Xing, Zhengkai Bao, Lu Xu, Yang Bai, Wanqi Chen, Wenhao Pan, Fang Cai, Qunxian Wang, Shipeng Guo, Jing Zhang, Zhe Wang, Yili Wu, Yun Zhang, Jia-Da Li, Weihong Song
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), and ectodomain shedding of the CNTNAP2 protein plays a role in its function. However, key enzymes involved in the C-termi
Externí odkaz:
https://doaj.org/article/19850e2db8e747e9b9ff10e5865eac4d
Autor:
Zhiyu Sun, Zhou Jin, Kejie Zhao, Xin Wen, Hui Lu, Nuonuo Hu, Qinxin Zhu, Yi Zhang, Minjie Ye, Yili Huang, Weihong Song, Deborah Baofeng Wang, Yili Wu
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background A considerable number of individuals infected with COVID-19 experience residual symptoms after the acute phase. However, the correlation between residual symptoms and psychological distress and underlying mechanisms are scarcely s
Externí odkaz:
https://doaj.org/article/9138239a0aba45aba4e07c2e749e2e88
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract There have been no previous reports of hippocampal radiomics features associated with biological functions in Alzheimer’s Disease (AD). This study aims to develop and validate a hippocampal radiomics model from structural magnetic resonanc
Externí odkaz:
https://doaj.org/article/e0f9c62c5c6c4037aa40f168102d9cfc
Autor:
Man Luo, Yayan Pang, Junjie Li, Lilin Yi, Bin Wu, Qiuyun Tian, Yan He, Maoju Wang, Lei Xia, Guiqiong He, Weihong Song, Yehong Du, Zhifang Dong
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 635-652 (2024)
Alzheimer's disease (AD) is a leading cause of dementia in the elderly. Mitogen-activated protein kinase phosphatase 1 (MKP-1) plays a neuroprotective role in AD. However, the molecular mechanisms underlying the effects of MKP-1 on AD have not been e
Externí odkaz:
https://doaj.org/article/3c74df04a92a4e7c9d31b5922b70dbad
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Cerebrovascular diseases (CVDs) are a major threat to global health. Elucidation of the molecular mechanisms underlying the pathology of CVDs is critical for the development of efficacious preventative and therapeutic approaches. Accumulatin
Externí odkaz:
https://doaj.org/article/64deddfaba324a42870df83ccda83eed
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-30 (2024)
Abstract Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected t
Externí odkaz:
https://doaj.org/article/8edf1340ca0c4a9ca9499044bab4c2fb