Brain permeable AMPK activator R481 raises glycemia by autonomic nervous system activation and amplifies the counterregulatory response to hypoglycemia in rats

Autor: Craig Beall, Shaw Sj, Ana M Cruz, Malekizadeh Y, Pye K, Weightman Potter Pg, Kate L. J. Ellacott, Vlachaki Walker Jm

AMP-activated protein kinase (AMPK) is a critical cellular and whole body energy sensor activated by energy stress, including hypoglycemia, which is frequently experienced by people with diabetes. Previous studies using direct delivery of an AMPK act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364c817eca0c5f994cba630e0eedf7b2
https://doi.org/10.1101/749929

Glutamate Prevents Altered Mitochondrial Function Following Recurrent Low Glucose in Hypothalamic but Not Cortical Primary Rat Astrocytes.

Autor: Weightman Potter PG; Department of Clinical and Biomedical Sciences, Faculty of Medicine and Health, University of Exeter Medical School, RILD Building, Barrack Road, Exeter EX2 5DW, UK., Ellacott KLJ; Department of Clinical and Biomedical Sciences, Faculty of Medicine and Health, University of Exeter Medical School, RILD Building, Barrack Road, Exeter EX2 5DW, UK., Randall AD; Department of Clinical and Biomedical Sciences, Faculty of Medicine and Health, University of Exeter Medical School, RILD Building, Barrack Road, Exeter EX2 5DW, UK., Beall C; Department of Clinical and Biomedical Sciences, Faculty of Medicine and Health, University of Exeter Medical School, RILD Building, Barrack Road, Exeter EX2 5DW, UK.

Publikováno v: Cells [Cells] 2022 Oct 29; Vol. 11 (21). Date of Electronic Publication: 2022 Oct 29.

Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose.

Autor: Weightman Potter PG; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom., Washer SJ; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom., Jeffries AR; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom., Holley JE; Royal Devon and Exeter Hospital, University of Exeter Medical School and the Department of Neurology, Exeter, United Kingdom., Gutowski NJ; Royal Devon and Exeter Hospital, University of Exeter Medical School and the Department of Neurology, Exeter, United Kingdom., Dempster EL; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom., Beall C; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom.

Publikováno v: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 May 26; Vol. 12, pp. 671724. Date of Electronic Publication: 2021 May 26 (Print Publication: 2021).

Immunometabolic Changes in Glia - A Potential Role in the Pathophysiology of Obesity and Diabetes.

Autor: Robb JL; Neuroendocrine Research Group, Institute of Biomedical & Clinical Sciences, University of Exeter Medical School, Exeter, UK., Morrissey NA; Neuroendocrine Research Group, Institute of Biomedical & Clinical Sciences, University of Exeter Medical School, Exeter, UK., Weightman Potter PG; Neuroendocrine Research Group, Institute of Biomedical & Clinical Sciences, University of Exeter Medical School, Exeter, UK., Smithers HE; Neuroendocrine Research Group, Institute of Biomedical & Clinical Sciences, University of Exeter Medical School, Exeter, UK., Beall C; Neuroendocrine Research Group, Institute of Biomedical & Clinical Sciences, University of Exeter Medical School, Exeter, UK., Ellacott KLJ; Neuroendocrine Research Group, Institute of Biomedical & Clinical Sciences, University of Exeter Medical School, Exeter, UK. Electronic address: k.ellacott@exeter.ac.uk.

Publikováno v: Neuroscience [Neuroscience] 2020 Nov 01; Vol. 447, pp. 167-181. Date of Electronic Publication: 2019 Nov 22.

AMP-activated protein kinase (AMPK) activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner.

Autor: Vlachaki Walker JM; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.; Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Robb JL; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK., Cruz AM; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK., Malhi A; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK., Weightman Potter PG; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK., Ashford MLJ; Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., McCrimmon RJ; Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Ellacott KLJ; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK., Beall C; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.; Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

Publikováno v: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2017 Jul; Vol. 19 (7), pp. 997-1005. Date of Electronic Publication: 2017 Apr 21.