Expert Consensus on the Diagnosis and Treatment of FGFR Gene-Altered Solid Tumors

Autor: Chunwei Xu, Bin Lian, Juanjuan Ou, Qian Wang, Wenxian Wang, Ke Wang, Dong Wang, Zhengbo Song, Aijun Liu, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Wen Li, Lili Mao, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Long Huang, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Rui Ge, Enyong Dai, Yu Han, Weiwei Pan, Fei Pang, Jintao Huang, Kai Wang, Fan Wu, Bingwei Xu, Liping Wang, Youcai Zhu, Li Lin, Yanru Xie, Xinqing Lin, Jing Cai, Ling Xu, Jisheng Li, Xiaodong Jiao, Kainan Li, Jia Wei, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yue Feng, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Zhaofeng Wang, Yue Hao, Zhen Wang, Bin Wan, Donglai Lv, Zhanqiang Zhai, Shengjie Yang, Jing Kang, Jiatao Zhang, Chao Zhang, Lin Shi, Yina Wang, Bihui Li, Zhang Zhang, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Huijuan Wang, Gu Jin, Guansong Wang, Jiandong Wang, Meiyu Fang, Yong Fang, Yuan Li, Xiaojia Wang, Jing Chen, Yiping Zhang, Xixu Zhu, Yi Shen, Shenglin Ma, Biyun Wang, Lu Si, Yuanzhi Lu, Ziming Li, Wenfeng Fang, Yong Song

Publikováno v: Global Medical Genetics, Vol 11, Iss 04, Pp 330-343 (2024)

The fibroblast growth factor receptor (FGFR) is a crucial receptor tyrosine kinase involved in essential biological processes, including growth, development, and tissue repair. However, FGFR gene mutations, including amplification, fusion, and mutati

Externí odkaz: https://doaj.org/article/d6d893b96da4470f8696347abc7c0079

Is intercalary frozen autograft augmented with intramedullary cement and bridging plates fixation a durable reconstruction?

Autor: Zhuoyu Li, Zhiping Deng, Yongkun Yang, Qing Zhang, Xiaohui Niu, Weifeng Liu

Publikováno v: Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-9 (2024)

Abstract Aims We analysed the survival, complications, and function of frozen autograft augmented with intramedullary cement and bridging plates fixation for intercalary bone defect reconstruction in primary bone sarcomas. Patients and Methods A retr

Externí odkaz: https://doaj.org/article/25ba1692ef804068abda1af93fc652ad

Survival and functional outcomes after hemiarthroplasty in children with proximal tibial osteosarcoma

Autor: Yuan Li, Hairong Xu, Yongkun Yang, Huachao Shan, Zhen Huang, Ke Ma, Weifeng Liu, Xiaohui Niu

Publikováno v: Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-10 (2024)

Abstract Background Treatment options for correcting limb-length discrepancy after limb-salvage reconstruction for proximal tibial osteosarcoma in children have several limitations. Therefore, we aimed to evaluate the feasibility, complications, prog

Externí odkaz: https://doaj.org/article/521d884d591b4f23b8cb820237b0805f

Denosumab combined with en bloc resection and arthrodesis for recurrent grade 3 giant cell tumor of bone in distal radius

Autor: Zhuoyu Li, Zhiping Deng, Yongkun Yang, Dalin Gao, Qing Zhang, Xiaohui Niu, Weifeng Liu

Publikováno v: Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-11 (2024)

Abstract Purpose This study aimed to analyse the clinical outcomes of preoperative adjuvant denosumab therapy (PADT) combined with resection and arthrodesis for recurrent grade 3 giant cell tumor of bone (GCTB) in the distal radius. Methods A retrosp

Externí odkaz: https://doaj.org/article/8dd2cc4c7827495893beffeeecdc2449

Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping

Autor: Jing-Jun Nie, Bowen Zhang, Peng Luo, Maoguo Luo, Yuwen Luo, Jingjing Cao, Honggang Wang, Jianping Mao, Yonggang Xing, Weifeng Liu, Yuning Cheng, Renxian Wang, Yajun Liu, Xinbao Wu, Xieyuan Jiang, Xiaoguang Cheng, Chi Zhang, Da-Fu Chen

Publikováno v: Bioactive Materials, Vol 38, Iss , Pp 455-471 (2024)

Osteosarcoma is the most common malignant bone tumor without efficient management for improving 5-year event-free survival. Immunotherapy is also limited due to its highly immunosuppressive tumor microenvironment (TME). Pore-forming gasdermins (GSDMs

Externí odkaz: https://doaj.org/article/edb31512544f4ad5a181b63aa3200040