MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage

Autor: Kalev, Peter, Hyer, Marc L., Gross, Stefan, Konteatis, Zenon, Chen, Chi-Chao, Fletcher, Mark, Lein, Max, Aguado-Fraile, Elia, Frank, Victoria, Barnett, Amelia, Mandley, Everton, Goldford, Joshua, Chen, Yue, Sellers, Katie, Hayes, Sebastian, Lizotte, Kate, Quang, Phong, Tuncay, Yesim, Clasquin, Michelle, Peters, Rachel, Weier, Jaclyn, Simone, Eric, Murtie, Joshua, Liu, Wei, Nagaraja, Raj, Dang, Lenny, Sui, Zhihua, Biller, Scott A., Travins, Jeremy, Marks, Kevin M., Marjon, Katya

Publikováno v: In Cancer Cell 8 February 2021 39(2):209-224

Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.

Autor: Martinez EM; Department of Molecular and Systems Biology., Young AL; Department of Molecular and Systems Biology., Patankar YR; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756., Berwin BL; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756., Wang L; Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226., von Herrmann KM; Department of Molecular and Systems Biology., Weier JM; Department of Molecular and Systems Biology., Havrda MC; Department of Molecular and Systems Biology.

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2017 Sep 01; Vol. 159 (1), pp. 64-75.