Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Weidong G. Lai"'
Autor:
Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
H3B-5942 exhibits dose-dependent inhibition of ER target genes and shows significant efficacy ER Wt and mutant in vivo models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9c652f36eba7990109355ffbc45bde
https://doi.org/10.1158/2159-8290.22532926
https://doi.org/10.1158/2159-8290.22532926
Autor:
Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
H3B-5942 suppresses co-activator recruitment and shows potency in endocrine sensitive and resistant lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fe67f0fb3f5a6e9b162e1258a6b471
https://doi.org/10.1158/2159-8290.22532932
https://doi.org/10.1158/2159-8290.22532932
Autor:
Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
ESR1 mutants are resistant to endocrine therapies in vitro and in vivo and H3B-5942 can suppress ER pathway activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e094f6bffb77028980e9dc3a07b8c45
https://doi.org/10.1158/2159-8290.22532935
https://doi.org/10.1158/2159-8290.22532935
Autor:
Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
C530 residue is critical for H3B-5942 potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b46076c6732fde388d82ec2a9bff96
https://doi.org/10.1158/2159-8290.22532920
https://doi.org/10.1158/2159-8290.22532920
Autor:
Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
H3B-5942 in combination with palbocyclib shows synergy in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130e94bb73b3d293c596f7bf7e1ddcba
https://doi.org/10.1158/2159-8290.22532923.v1
https://doi.org/10.1158/2159-8290.22532923.v1
Autor:
Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
Additional methods provided.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d273e24b0b70562bfd8ace053d7ea075
https://doi.org/10.1158/2159-8290.22532917.v1
https://doi.org/10.1158/2159-8290.22532917.v1
Autor:
Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
Enriched GSEA pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448ee55b6f74e7115d7952f4c0f92306
https://doi.org/10.1158/2159-8290.22532911.v1
https://doi.org/10.1158/2159-8290.22532911.v1
Autor:
Manav Korpal, Ping Zhu, Peter G. Smith, Markus Warmuth, Lihua Yu, Shihua Yao, Michael J. Wick, Suzanne Wardell, John Wang, Frédéric H. Vaillancourt, Michael Thomas, Vanitha Subramanian, Sasirekha Sivakumar, Amy Siu, Ricardo Ribas, Nathalie Rioux, Victoria Rimkunas, Dominic J. Reynolds, Sujatha Rajagopalan, Sudeep Prajapati, Sunil Pancholi, Morgan O'Shea, John Norris, Tuong-Vi Nguyen, Alyssa Moriarty, Diana Melchers, Lesley-Ann Martin, Crystal Mackenzie, Nicholas Larsen, Weidong G. Lai, Galina Kuznetsov, Pavan Kumar, Namita Kumar, Amy Kim, Craig Karr, Jaya J. Joshi, Sean Irwin, René Houtman, Andrew Hart, Ming-Hong Hao, Peter Fekkes, Sean Eckley, Subhasree Das, Benjamin Caleb, Silvia Buonamici, David M. Bolduc, Sergei Agoulnik, Kiran Aithal, Deepti Banka, Zhenhua J. Wu, Guo Zhu Zheng, Craig Furman, Xiaoling Puyang
Crystallography and amino acid coordinates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336089bcd742506a0a9e9510a554baa5
https://doi.org/10.1158/2159-8290.22532914
https://doi.org/10.1158/2159-8290.22532914
Autor:
Anand Selvaraj, Peter G. Smith, Dominic J. Reynolds, Markus Warmuth, John Wang, Peter Fekkes, Nicholas Larsen, Silvia Buonamici, Ping Zhu, Lihua Yu, Weidong G. Lai, Amy Kim, Nathalie Rioux, Eunice Park, Kun Yu, Takashi Satoh, Raelene Hurley, Crystal MacKenzie, Pavan Kumar, Vanitha Subramanian, Craig Karr, Victoria Rimkunas, Jeremy Wu, Suzanna Bailey, Ming-Hong Hao, Sudeep Prajapati, Kana Ichikawa, Chia-Ling Huang, Jennifer Tsai, Erik Corcoran, Heather Coffey, Jaya Julie Joshi
Legends describing each of the supplementary figures and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17337747eba930787f2115302a5a5162
https://doi.org/10.1158/0008-5472.22416069.v1
https://doi.org/10.1158/0008-5472.22416069.v1
Autor:
Anand Selvaraj, Peter G. Smith, Dominic J. Reynolds, Markus Warmuth, John Wang, Peter Fekkes, Nicholas Larsen, Silvia Buonamici, Ping Zhu, Lihua Yu, Weidong G. Lai, Amy Kim, Nathalie Rioux, Eunice Park, Kun Yu, Takashi Satoh, Raelene Hurley, Crystal MacKenzie, Pavan Kumar, Vanitha Subramanian, Craig Karr, Victoria Rimkunas, Jeremy Wu, Suzanna Bailey, Ming-Hong Hao, Sudeep Prajapati, Kana Ichikawa, Chia-Ling Huang, Jennifer Tsai, Erik Corcoran, Heather Coffey, Jaya Julie Joshi
RNA-seq analysis of 24 CCLE HCC cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91becaed60e0cada02bff298a9271299
https://doi.org/10.1158/0008-5472.22416084
https://doi.org/10.1158/0008-5472.22416084