COVID-19: from GU-rich single-stranded RNA to cytokine storm to pulmonary embolism. The molecular pathophysiology of COVID-19-associated thrombosis

Autor: Sloop, Gregory, Pop, Gheorghe, Weidman, Joseph J, Cyr, John A. St.

We hypothesize that the SARS-CoV-2 genome contains an extraordinarily high content of GU-rich sequences. These are known to activate the TLR-8 pathway of innate immunity, causing the cytokine storm in COVID-19. The result is upregulation of the expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359f1635999604081dab3b1e4a709bd8

Perspective: interesterified triglycerides, the recent increase in deaths from heart disease, and elevated blood viscosity.

Autor: Sloop, Gregory D., Weidman, Joseph J., St Cyr, John A.

Publikováno v: Therapeutic Advances in Cardiovascular Disease; Jan2018, Vol. 12 Issue 1, p23-28, 6p

The systemic vascular resistance response: a cardiovascular response modulating blood viscosity with implications for primary hypertension and certain anemias.

Autor: Sloop, Gregory D., Weidman, Joseph J., St. Cyr, John A.

Publikováno v: Therapeutic Advances in Cardiovascular Disease; Dec2015, Vol. 9 Issue 6, p403-411, 9p

The role of chronic hyperviscosity in vascular disease.

Autor: Sloop, Gregory, Holsworth, Ralph E., Weidman, Joseph J., St Cyr, John A.

Publikováno v: Therapeutic Advances in Cardiovascular Disease; Feb2015, Vol. 9 Issue 1, p19-25, 7p

New Onset Anemia, Worsened Plasma Creatinine Concentration, and Hyperviscosity in a Patient With a Monoclonal IgM Paraprotein.

Autor: Sloop GD; Pathology, Idaho College of Osteopathic Medicine, Meridian, USA., Moore C; Laboratory Services, Community Hospital of Monterey Peninsula, Monterey, USA., Pop G; Cardiology, Radboud University Medical Center, Nijmegen, NLD., Weidman JJ; Internal Medicine, Independent Researcher, Columbia, USA., St Cyr JA; Cardiac/Thoracic/Vascular Surgery, Jacqmar Inc., Minneapolis, USA.

Publikováno v: Cureus [Cureus] 2023 Jul 10; Vol. 15 (7), pp. e41657. Date of Electronic Publication: 2023 Jul 10 (Print Publication: 2023).