Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Weidao Zhang"'
Publikováno v:
Bio-Protocol, Vol 13, Iss 21 (2023)
Fork stability is key to genome DNA duplication and genetic integrity. Long non-coding RNAs (LncRNAs) may play vital roles in fork stabilization and chromatin remodeling. Existing techniques such as NCC-RNA sequencing are useful to identify LncRNAs o
Externí odkaz:
https://doaj.org/article/6d8ae7ae84df432b93e4a03097cdd06c
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Various lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress respon
Externí odkaz:
https://doaj.org/article/56a478158e624d08ac79bc64bc5d9483
Autor:
Weidao Zhang, Zhongliang Chen, Dengfeng Zhang, Bo Zhao, Lu Liu, Zhengyuan Xie, Yonggang Yao, Ping Zheng
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000468 (2019)
Recurrent pregnancy loss (RPL) is an important complication in reproductive health. About 50% of RPL cases are unexplained, and understanding the genetic basis is essential for its diagnosis and prognosis. Herein, we report causal KH domain containin
Externí odkaz:
https://doaj.org/article/8568c646525c4cbfaaf43c07cd7cf22c
Publikováno v:
Stem Cell Reports. 18:952-968
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a885253df9f8ca91b22fc625d4b5fa7
https://doi.org/10.1016/j.stemcr.2023.02.003
https://doi.org/10.1016/j.stemcr.2023.02.003
Publikováno v:
Science Advances. 9
Maintaining genomic stability is crucial for embryonic stem cells (ESCs). ESCs with unrepaired DNA damage are eliminated through differentiation and apoptosis. To date, only tumor suppressor p53 is known to be implicated in this quality control proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11916bc0704c7edb1a7f469985d71abc
https://doi.org/10.1126/sciadv.ade9742
https://doi.org/10.1126/sciadv.ade9742
Replication stress is a major source of endogenous DNA damage. Despite the identification of numerous proteins on replication forks to modulate fork or replication machinery activities, it remains unexplored whether noncoding RNAs can localize on sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b62688ce10d9a47e57ef72109df902
https://doi.org/10.1101/2022.03.13.484185
https://doi.org/10.1101/2022.03.13.484185
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
RPA is a master regulator of DNA metabolism and RPA availability acts as a rate-limiting factor. While numerous studies focused on the post-translational regulations of RPA for its functions, little is known regarding how RPA availability is controll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d5f1a16c82404f776aba7b25d46678
http://europepmc.org/articles/PMC8458541
http://europepmc.org/articles/PMC8458541
Autor:
Ping Zheng, Lu Liu, Deng-Feng Zhang, Zhongliang Chen, Zhengyuan Xie, Bo Zhao, Weidao Zhang, Yong-Gang Yao
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 10, p e3000468 (2019)
PLoS Biology, Vol 17, Iss 10, p e3000468 (2019)
Recurrent pregnancy loss (RPL) is an important complication in reproductive health. About 50% of RPL cases are unexplained, and understanding the genetic basis is essential for its diagnosis and prognosis. Herein, we report causal KH domain containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e359ece7b466e9d4c0806c1a97b2fd5
http://europepmc.org/articles/PMC6812846
http://europepmc.org/articles/PMC6812846
Autor:
Jingzheng Li, Rugang Zhang, Yan Liu, Hongwen Zhu, Weidao Zhang, Yi-xian Cun, Bo Zhao, Ping Zheng, Jing Gao, Hu Zhou
Publikováno v:
Cell research. 28(1)
Pluripotent stem cells (PSCs) harbor constitutive DNA replication stress during their rapid proliferation and the consequent genome instability hampers their applications in regenerative medicine. It is therefore important to understand the regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2547e1535fdb9f43f3c84ed68291a4
https://pubmed.ncbi.nlm.nih.gov/29125140
https://pubmed.ncbi.nlm.nih.gov/29125140
Autor:
Wenhui Nie, Rugang Zhang, Yi-xian Cun, Kun Guo, Yong-qing Lu, Bo Zhao, Ying-liang Duan, Lei Li, Chao-hui Li, Weidao Zhang, Ping Zheng
SummaryPluripotent stem cells (PSCs) hold great promise in cell-based therapy, but the genomic instability seen in culture hampers their full application. A greater understanding of the factors that regulate genomic stability in PSCs could help addre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02352bbd48f1f6a861ff8fe96f9cc925
https://europepmc.org/articles/PMC4610728/
https://europepmc.org/articles/PMC4610728/