Výsledky vyhledávání - "Weichao G. Chen"

Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation

Autor: Weichao G. Chen, Khawja A. Usmani, Chuan Chen, Safet Palamar, Abu J.M. Sadeque, Matthew A. Cerny

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 44(4)

Lorcaserin [(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine] hydrochloride hemihydrate, a selective serotonin 5-hydroxytryptamine (5-HT) 5-HT(2C) receptor agonist, is approved by the U.S. Food and Drug Administration for chronic weight mana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e023a70649cdae3855bfe98d6f2215
https://pubmed.ncbi.nlm.nih.gov/26758853

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Biopharmaceutics permeability classification of lorcaserin, a selective 5-hydroxytryptamine 2C agonist: method suitability and permeability class membership

Autor: Michael G. Ma, Cody L. Fullenwider, Weichao G. Chen, Abu J.M. Sadeque, Chuan Chen

Publikováno v: Molecular pharmaceutics. 10(12)

The objectives of the study were (1) to demonstrate that a Caco-2 cell-based permeability assay, developed in our laboratory, is suitable to identify the permeability classification according to the US Food and Drug Administration Biopharmaceutics Cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b3b135828f3f4858c4a2e35561ed8d
https://pubmed.ncbi.nlm.nih.gov/24102111

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Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist

Autor: Khawja A. Usmani, Weichao G. Chen, Abu J.M. Sadeque

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 40(4)

Lorcaserin, a selective serotonin 5-hydroxytryptamine 2C receptor agonist, is being developed for weight management. The oxidative metabolism of lorcaserin, mediated by recombinant human cytochrome P450 (P450) and flavin-containing monooxygenase (FMO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15958074a1432491c97da4ddd7fbe53d
https://pubmed.ncbi.nlm.nih.gov/22266842

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Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin

Autor: Abu J.M. Sadeque, Matthew A. Cerny, Khawja A. Usmani, Safet Palamar, Weichao G. Chen

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 40(4)

Lorcaserin, a selective serotonin 5-HT(2C) receptor agonist, is a weight management agent in clinical development. Lorcaserin N-carbamoyl glucuronidation governs the predominant excretory pathway of lorcaserin in humans. Human UDP-glucuronosyltransfe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc551ce7dd2e45e408c6d2fb88a90da8
https://pubmed.ncbi.nlm.nih.gov/22259019

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Metabolism and disposition of a potent group II metabotropic glutamate receptor agonist, in rats, dogs, and monkeys

Autor: Joyce K. James, Janice Brunner, Weichao G. Chen, Masato Nakamura, Merryl Cramer, Atsuro Nakazato, Kanyin E. Zhang, Jacquelynn Cook

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 33(9)

Metabolism and disposition of MGS0028 [(1 R ,2 S ,5 S ,6 S )-2-amino-6-fluoro-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid monohydrate], a potent group II metabotropic glutamate receptor agonist, were examined in three preclinical species (Sprague

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40231f6bbcd743bb86982031ef6b91b7
https://pubmed.ncbi.nlm.nih.gov/15980102

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