Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Weian, Zhao"'
Autor:
Sebastian D. Schubl, Cesar Figueroa, Anton M. Palma, Rafael R. de Assis, Aarti Jain, Rie Nakajima, Algimantas Jasinskas, Danielle Brabender, Sina Hosseinian, Ariana Naaseh, Oscar Hernandez Dominguez, Ava Runge, Shannon Skochko, Justine Chinn, Adam J. Kelsey, Kieu T. Lai, Weian Zhao, Peter Horvath, Delia Tifrea, Areg Grigorian, Abran Gonzales, Suzanne Adelsohn, Frank Zaldivar, Robert Edwards, Alpesh N. Amin, Michael J. Stamos, Philip S. Barie, Philip L. Felgner, Saahir Khan
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background While others have reported severe acute respiratory syndrome-related coronavirus 2(SARS-CoV-2) seroprevalence studies in health care workers (HCWs), we leverage the use of a highly sensitive coronavirus antigen microarray to ident
Externí odkaz:
https://doaj.org/article/973fd629d2954ecc9a3ca5067b33e8b3
Autor:
Aude I. Segaliny, Jayapriya Jayaraman, Xiaoming Chen, Jonathan Chong, Ryan Luxon, Audrey Fung, Qiwei Fu, Xianzhi Jiang, Rodrigo Rivera, Xiaoya Ma, Ci Ren, Jan Zimak, Per Niklas Hedde, Yonglei Shang, George Wu, Weian Zhao
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
A single-cell based bispecific antibody (BsAb) discovery pipeline, based on a microfluidics droplets generation and sorting systems, has the potential to speed up the discovery and development of functional antibodies such as BsAb therapeutics.
Externí odkaz:
https://doaj.org/article/7a14b50910074c84bb0bfc0a503c1bb8
Autor:
Qian Lu, Bo Pan, Haobo Bai, Weian Zhao, Lingjuan Liu, Gu Li, Ruimin Liu, Tiewei Lv, Xupei Huang, Xi Li, Jie Tian
Publikováno v:
Genes and Diseases, Vol 9, Iss 6, Pp 1689-1700 (2022)
In the past studies, it is shown that cardiac troponin I (cTnI, encoded by TNNI3), as a cytoplasmic protein, is an inhibitory subunit in troponin complex, and involves in cardiomyocyte diastolic regulation. Here, we assessed a novel role of cTnI as a
Externí odkaz:
https://doaj.org/article/19e358c312d94275bd23b9a5781a1667
Autor:
Tam Vu, Alexander Vallmitjana, Joshua Gu, Kieu La, Qi Xu, Jesus Flores, Jan Zimak, Jessica Shiu, Linzi Hosohama, Jie Wu, Christopher Douglas, Marian L. Waterman, Anand Ganesan, Per Niklas Hedde, Enrico Gratton, Weian Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Spatial-omics methods with ease-of-use and high multiplexing are in demand. Here the authors report Multi Omic Single-scan Assay with Integrated Combinatorial Analysis (MOSAICA) which uses Spectral and Fluorescence Lifetime Imaging and Microscopy; th
Externí odkaz:
https://doaj.org/article/3a42cb1c065c4f01927be67c3c3c58b9
Publikováno v:
Genes and Diseases, Vol 8, Iss 4, Pp 569-579 (2021)
Cardiac Troponin I (cTnI) is a subunit of the thin filament involved in regulation of heart contraction. Mutated cTnI accounts for most genetic mutations associated with restrictive cardiomyopathy (RCM). We previously found phosphodiesterase 4D (PDE4
Externí odkaz:
https://doaj.org/article/1fb8b69773ca46569a4efc5af57a422a
Autor:
M. Rezaa Mohammadi, Samuel Mathew Rodriguez, Jennifer Cam Luong, Shiri Li, Rui Cao, Hamad Alshetaiwi, Hien Lau, Hayk Davtyan, Mathew Blurton Jones, Mahtab Jafari, Kai Kessenbrock, S. Armando Villalta, Paul de Vos, Weian Zhao, Jonathan R. T. Lakey
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Mohammadi et al. show that the transplantation of pancreatic islets within mesenchymal-stem cell (MSC) exosome-loaded hybrid alginate microcapsules in diabetic mice lead to diminished immune-based foreign body response and hyperglycemia control. This
Externí odkaz:
https://doaj.org/article/2679dce50030425f97c4feb28fe920b9
Autor:
Joshua Gu, Hannah Jian, Christine Wei, Jessica Shiu, Anand Ganesan, Weian Zhao, Per Niklas Hedde
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7008 (2023)
To image 4-plex immunofluorescence-stained tissue samples at a low cost with cellular level resolution and sensitivity and dynamic range required to detect lowly and highly abundant targets, here we describe a robust, inexpensive (10 times more expen
Externí odkaz:
https://doaj.org/article/d6ed2f66448844618e528ac44a551911
Autor:
Jan Zimak, Zachary W. Wagoner, Nellie Nelson, Brooke Waechtler, Hana Schlosser, Morgan Kopecky, Jie Wu, Weian Zhao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract We report that epigenetic silencing causes the loss of function of multi-transcript unit constructs that are integrated using CRISPR-Cas9. Using a modular two color reporter system flanked by selection markers, we demonstrate that expression
Externí odkaz:
https://doaj.org/article/99a5ea87ae6540f48bce4ae7dceb0557
Autor:
Sungjun Beck, Rie Nakajima, Algis Jasinskas, Timothy J. Abram, Sun Jin Kim, Nader Bigdeli, Delia F. Tifrea, Jenny Hernandez-Davies, D. Huw Davies, Per Niklas Hedde, Philip L. Felgner, Weian Zhao
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2238 (2022)
High-throughput and rapid screening testing is highly desirable to effectively combat the rapidly evolving COVID-19 pandemic co-presents with influenza and seasonal common cold epidemics. Here, we present a general workflow for iterative development
Externí odkaz:
https://doaj.org/article/23012589569b4c5d8fcec8a9f9ae2c26
Autor:
Linan Liu, Chi W. Wong, Menglu Han, Henry P. Farhoodi, Guangyang Liu, Yongjun Liu, Wenbin Liao, Weian Zhao
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 563-577 (2019)
Background: This study aims to evaluate the quality of preclinical data, determine the effect sizes, and identify experimental measures that inform efficacy using mesenchymal stromal (or stem) cells (MSC) therapy in animal models of rheumatoid arthri
Externí odkaz:
https://doaj.org/article/caedcffb12cf4a08a3ef13578ec437cc