A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments

Autor: Xiao-Hua Li, Wei-Wei Pang, Yue Zhang, Dan-Yang Liu, Qiao-Rong Yi, Ning Wang, Fu-Rong Zhang, Yun Deng, Xiang-Ding Chen, Jonathan Greenbaum, Hong-Mei Xiao, Hong-Wen Deng, Li-Jun Tan

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Background: Lipid pathways have been implicated in the pathogenesis of osteoporosis (OP). Lipid-lowering drugs may be used to prevent and treat OP. However, the causal interpretation of results from traditional observational designs is controversial

Externí odkaz: https://doaj.org/article/4e5054e920bf42d7b28f96aa42204676

Ethnic diversity in infant gut microbiota is apparent before the introduction of complementary diets

Autor: Jia Xu, Blair Lawley, Gerard Wong, Anna Otal, Li Chen, Toh Jia Ying, Xinyi Lin, Wei Wei Pang, Fabian Yap, Yap-Seng Chong, Peter D. Gluckman, Yung Seng Lee, Mary Foong-Fong Chong, Gerald W. Tannock, Neerja Karnani

Publikováno v: Gut Microbes, Vol 11, Iss 5, Pp 1362-1373 (2020)

The human gut microbiota develops soon after birth and can acquire inter-individual variation upon exposure to intrinsic and environmental cues. However, inter-individual variation has not been comprehensively assessed in a multi-ethnic study. We stu

Externí odkaz: https://doaj.org/article/58ae9c721d914a3798ea33191d85d51d

Timing of introduction of complementary foods, breastfeeding, and child cardiometabolic risk: a prospective multiethnic Asian cohort study

Autor: Yi Ying Ong, Wei Wei Pang, Navin Michael, Izzuddin M. Aris, Suresh Anand Sadananthan, Mya-Thway Tint, Jonathan Tze Liang Choo, Lieng Hsi Ling, Neerja Karnani, S Sendhil Velan, Marielle V. Fortier, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith M. Godfrey, Shiao-Yng Chan, Johan G. Eriksson, Mary F-F Chong, Mary E. Wlodek, Yung Seng Lee

Publikováno v: The American Journal of Clinical Nutrition. 117:83-92

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2114eefb961aa1347c0c93d9023bff12
https://doi.org/10.1016/j.ajcnut.2022.10.021

Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study

Autor: Izzuddin M. Aris, Ling-Wei Chen, Mya Thway Tint, Wei Wei Pang, Shu E. Soh, Seang-Mei Saw, Lynette Pei-Chi Shek, Kok-Hian Tan, Peter D. Gluckman, Yap-Seng Chong, Fabian Yap, Keith M. Godfrey, Michael S. Kramer, Yung Seng Lee

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract We investigated body mass index (BMI) trajectories in the first 2 years of life in 1170 children from an Asian mother-offspring cohort in Singapore, and examined their predictors and associations with childhood cardio-metabolic risk measures

Externí odkaz: https://doaj.org/article/a4f07ca2bef94e68a5491e4d885cd39d

Nutrient trajectories during infancy and their associations with childhood neurodevelopment

Autor: Jia Ying Toh, Shirong Cai, Shan Xuan Lim, Wei Wei Pang, Keith M. Godfrey, Lynette P. Shek, Kok Hian Tan, Fabian Yap, Yung Seng Lee, Yap-Seng Chong, Johan G. Eriksson, Birit F. P. Broekman, Anne Rifkin‑Graboi, Mary F. F. Chong

Publikováno v: Toh, J Y, Cai, S, Lim, S X, Pang, W W, Godfrey, K M, Shek, L P, Tan, K H, Yap, F, Lee, Y S, Chong, Y-S, Eriksson, J G, Broekman, B F P, Rifkin‑Graboi, A & Chong, M F F 2023, ' Nutrient trajectories during infancy and their associations with childhood neurodevelopment ', European Journal of Nutrition . https://doi.org/10.1007/s00394-023-03164-2
European Journal of Nutrition. D. Steinkopff-Verlag

Purpose: To examine the associations between infants' dietary nutrient trajectories and subsequent neurodevelopment during childhood in the Growing Up in Singapore Towards healthy Outcomes study.Methods: One-day food records were collected at ages 6,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053c3f55adc3b4d968e52171dd848090
https://eprints.soton.ac.uk/477585/